Professor John Peever

John H. Peever

Professor


Campus

St. George (downtown)

CSB Appointment

Full

Research Areas

Animal Biology, Molecular Biology, Neurobiology, Pathology, Physiology, Systems Biology

Education

Ph.D. University of Toronto 2001

Titles and Honors

CIHR Research Fellow

Primary Undergraduate Department

Cell & Systems Biology

Graduate Programs

Cell & Systems Biology

Academic or Administrative Appointments

Director Centre for Biology Timing and Cognition
Associate Chair Graduate Studies, Department of Cell and Systems Biology
Associate Journal Editor @ Sleep and Frontiers in Neuroscience
VP Research Canadian Sleep Society

Research Description

Our research explores how the brain controls sleep and why changes in sleep control contribute to neurological disorders. My lab uses optogenetics, chemogenetics and live cell imaging to interrogate the brain circuits that control sleep, particularly REM sleep. Our research is also focussed on understanding how and why pathology in sleep circuitry contributes to sleep disorders (e.g., narcolepsy and REM sleep behavior disorder), and neurodegenerative diseases (e.g., Parkinson’s disease and dementia).


Contact Information

Office Phone: 416-946-5564
Office: 325 Huron St, Room 278a
Lab: 325 Huron St, Room 278 & 307
Lab Phone: 416-946-7236
Email

Mailing Address

Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada

Visit lab’s website


Recent News

Staying up for the Awards: Anita Taksokhan earns CSS-Jazz award for sleep research

A good night’s sleep leads to an active, productive day for most of us, but a rare condition called idiopathic hypersomnia (IH) can lead some people…

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Keep on moving: paralysis of narcolepsy relieved by chemogenetic cell therapy in mice

Anyone affected by the sleep disorder narcolepsy can experience sudden paralysis that causes them to collapse in the middle of their day, a symptom…

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Professor John Peever earns Distinguished Scientist Award from the Canadian Sleep Society

Professor John Peever is this year’s recipient of the Canadian Sleep Society's (CSS-SCS) Distinguished Scientist Award. This award recognizes a…

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Publications

2023

Immortal orexin cell transplants restore motor-arousal synchrony during cataplexy

Pintwala SK, Fraigne JJ, Belsham DD, Peever JH
2023, Current Biology, 10.1016/j.cub.2023.03.077

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2021

Neuroscience: Glutamate neurons in the medial septum control wakefulness

Taksokhan A, Fraigne J, Peever J
2021, Current Biology, 10.1016/j.cub.2021.03.006

Brain Circuits Underlying Narcolepsy

Pintwala SK, Peever J
2021, The Neuroscientist, 10.1177/10738584211052263

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2020

John Peever

Peever J
2020, Current Biology, 10.1016/j.cub.2020.08.057

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2019

Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy.

Szabo ST, Thorpy MJ, Mayer G, Peever JH, Kilduff TS
2019, Sleep medicine reviews, 43, 23-36, 30503715

The Sublaterodorsal Tegmental Nucleus Functions to Couple Brain State and Motor Activity during REM Sleep and Wakefulness

Torontali ZA, Fraigne JJ, Sanghera P, Horner R, Peever J
2019, Current Biology, 10.1016/j.cub.2019.09.026

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2018

Brainstem Nuclei Associated with Mediating Apnea-Induced Respiratory Motor Plasticity.

Lui S, Torontali Z, Tadjalli A, Peever J
2018, Scientific reports, 8, 12709, 30139983

Neuroscience: A ‘Skin Warming’ Circuit that Promotes Sleep and Body Cooling.

Peever J
2018, Current biology : CB, 28, R800-R802, 30040944

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2017

The Biology of REM Sleep.

Peever J, Fuller PM
2017, Current biology : CB, 27, R1237-R1248, 29161567

Brain Circuitry Controlling Sleep and Wakefulness.

Horner RL, Peever JH
2017, Continuum (Minneapolis, Minn.), 23, 955-972, 28777170

Degeneration of rapid eye movement sleep circuitry underlies rapid eye movement sleep behavior disorder.

McKenna D, Peever J
2017, Movement disorders : official journal of the Movement Disorder Society, 32, 636-644, 28394031

Circuit mechanisms of sleepiness and cataplexy in narcolepsy.

Pintwala S, Peever J
2017, Current opinion in neurobiology, 44, 50-58, 28343142

GABA Cells in the Central Nucleus of the Amygdala Promote Cataplexy.

Snow MB, Fraigne JJ, Thibault-Messier G, Chuen VL, Thomasian A, Horner RL, Peever J
2017, The Journal of neuroscience : the official journal of the Society for Neuroscience, 37, 4007-4022, 28209737

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2016

Monoamine Release during Unihemispheric Sleep and Unihemispheric Waking in the Fur Seal

Lyamin OI, Lapierre JL, Kosenko PO, Kodama T, Bhagwandin A, Korneva SM, Peever JH, Mukhametov LM, Siegel JM
2016, Sleep, 39, 625-36, 26715233

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2014

Noradrenergic modulation of masseter muscle activity during natural rapid eye movement sleep requires glutamatergic signalling at the trigeminal motor nucleus

Schwarz PB, Mir S, Peever JH
2014, The Journal of physiology, 24860176

Cataplexy-clinical aspects, pathophysiology and management strategy

Dauvilliers Y, Siegel JM, Lopez R, Torontali ZA, Peever JH
2014, Nature reviews. Neurology, 10, 386-95, 24890646

Cholinergic involvement in control of REM sleep paralysis

Torontali ZA, Grace KP, Horner RL, Peever JH
2014, The Journal of physiology, 592, 1425-6, 24692459

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2013

Melanin-concentrating hormone neurons promote and stabilize sleep

Fraigne JJ, Peever JH
2013, Sleep, 36, 1767-8, 24293745

Brain biology: jerked around by sleep

Fraigne JJ, Peever JH
2013, Current biology : CB, 23, R954-6, 24200321

A noradrenergic mechanism functions to couple motor behavior with arousal state

Burgess CR, Peever JH
2013, Current biology : CB, 23, 1719-25, 23993842

Amygdala lesions reduce cataplexy in orexin knock-out mice

Burgess CR, Oishi Y, Mochizuki T, Peever JH, Scammell TE
2013, The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 9734-42, 23739970

Symmetrical serotonin release during asymmetrical slow-wave sleep: implications for the neurochemistry of sleep-waking states

Lapierre JL, Kosenko PO, Kodama T, Peever JH, Mukhametov LM, Lyamin OI, Siegel JM
2013, The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 2555-61, 23392683

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2012

Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis

Brooks PL, Peever JH
2012, The Journal of neuroscience : the official journal of the Society for Neuroscience, 32, 9785-95, 22815493

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2011

Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump

Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess CR, Petersen J, Jarowek KJ, Yücel YH, Cortez MA, Snead OC, Vilsen B, Peever JH, Ralph MR, Roder JC
2011, Proceedings of the National Academy of Sciences of the United States of America, 108, 18144-9, 22025725

Dopamine triggers skeletal muscle tone by activating D1-like receptors on somatic motoneurons

Schwarz PB, Peever JH
2011, Journal of neurophysiology, 106, 1299-309, 21653722

Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice

Brooks PL, Peever JH
2011, The Journal of neuroscience : the official journal of the Society for Neuroscience, 31, 7111-21, 21562273

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2010

Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy

Burgess CR, Tse G, Gillis L, Peever JH
2010, Sleep, 33, 1295-304, 21061851

Noradrenergic control of trigeminal motoneurons in sleep: relevance to sleep apnea

Schwarz PB, Peever JH
2010, Advances in experimental medicine and biology, 669, 281-4, 20217366

GABAergic and glycinergic control of upper airway motoneurons in rapid eye movement sleep

Brooks PL, Peever JH
2010, Advances in experimental medicine and biology, 669, 259-62, 20217361

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2008

Unraveling the mechanisms of REM sleep atonia

Brooks PL, Peever JH
2008, Sleep, 31, 1492-7, 19226735

Noradrenaline triggers muscle tone by amplifying glutamate-driven excitation of somatic motoneurones in anaesthetized rats

Schwarz PB, Yee N, Mir S, Peever JH
2008, The Journal of physiology, 586, 5787-802, 18845613

Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia

Brooks PL, Peever JH
2008, The Journal of neuroscience : the official journal of the Society for Neuroscience, 28, 3535-45, 18385312

Biochemical control of airway motor neurons during rapid eye movement sleep

Brooks PL, Peever JH
2008, Advances in experimental medicine and biology, 605, 437-41, 18085313

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2003

Connections between respiratory neurones in the neonatal rat transverse medullary slice studied with cross-correlation

Li YM, Shen L, Peever JH, Duffin J
2003, The Journal of physiology, 549, 327-32, 12692183

Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism

Peever JH, Lai YY, Siegel JM
2003, Journal of neurophysiology, 89, 2591-600, 12611960

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2002

Acetazolamide and respiratory chemosensitivity to CO(2) in the neonatal rat transverse medullary slice

Necakov A, Peever JH, Shen L, Duffin J
2002, Respiratory physiology & neurobiology, 132, 279-87, 12208086

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2001

Bilateral coordination of inspiratory neurones in the rat

Shen L, Peever JH, Duffin J
2002, Pflügers Archiv : European journal of physiology, 443, 829-35, 11889582

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