Robert Gerlai

faculty_img Academic Title: Professor

Campus: UTM

CSB Appointment: Cross Appointment

Primary Undergraduate Department:
Biology, UTM

Graduate Programs:
Cell & Systems Biology
Chemical & Physical Sciences

Titles and Honors:
Past president of IBNS, 2013
Distinguished Scientist awardee of IBANGS
Fellow of IBNS

Academic or Administrative Appointments:


Education:
Ph.D. D.Sc. Hungarian Academy of Sciences 1987 & 1987
M.Sc. Eotvos University of Budapest 1984

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
3359 Mississauga Road North
Mississauga, ON L5L 1C6
Canada
 

 

Contact Information
Office phone: 905-569-4255 
Office: DV 3035 
Lab: DV 1013 
Lab phone: 905-569-4257 
Email: robert.gerlai@utoronto.ca 
URL:

 

Research Areas
Genetics
Neurobiology
Psychology & Behavior

 

Research

Dr. Gerlai’s research has been focussing on the biological and genetic mechanisms of behaviour. He is known for his work on behavioural phenotyping of genetically engineered mice and more recently for the characterization of numerous aspects of the behaviour of zebrafish. For example, his paper on the pros and cons of gene targeting published in TINS in 1996 received over a thousand citations. He is also known for his work on Eph tyrosine kinase receptors and their roles in learning and memory. Dr. Gerlai’s current research at U of T concerns behavioral phenotyping and forward genetic (mutagenesis) and psychopharmacological approaches with zebrafish to study such questions as the mechanisms of alcohol abuse, social behaviour and of learning and memory.

 

Publications

2014

Top
Diving deeper into Zebrafish development of social behavior: Analyzing high resolution data.Buske C, Gerlai R.J. Neurosci. Methods 2014 Aug;234:66-72
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Acute Net Stressor Increases Whole-Body Cortisol Levels Without Altering Whole-Brain Monoamines in Zebrafish.Tran S, Chatterjee D, Gerlai R.Behav. Neurosci. 2014 Jun;
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Short-term memory in zebrafish (Danio rerio).Jia J, Fernandes Y, Gerlai R.Behav. Brain Res. 2014 Aug;270:29-36
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Social behavior of zebrafish: From synthetic images to biological mechanisms of shoaling.Gerlai R.J. Neurosci. Methods 2014 Aug;234:59-65
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Fish in behavior research: Unique tools with a great promise!.Gerlai R.J. Neurosci. Methods 2014 Aug;234C:54-58
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Zebrafish models for translational neuroscience research: from tank to bedside.Stewart AM, Braubach O, Spitsbergen J, Gerlai R, Kalueff AV.Trends Neurosci. 2014 May;37(5):264-78
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An integrative analysis of ethanol tolerance and withdrawal in zebrafish (Danio rerio).Tran S, Chatterjee D, Gerlai R.Behav. Brain Res. 2014 Mar;
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Embryonic alcohol exposure impairs associative learning performance in adult zebrafish.Fernandes Y, Tran S, Abraham E, Gerlai R.Behav. Brain Res. 2014 May;265:181-7
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Recent advances with a novel model organism: Alcohol tolerance and sensitization in zebrafish (Danio rerio).Tran S, Gerlai R.Prog. Neuropsychopharmacol. Biol. Psychiatry 2014 Mar;
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Induction of social behavior in zebrafish: live versus computer animated fish as stimuli.Qin M, Wong A, Seguin D, Gerlai R.Zebrafish 2014 Jun;11(3):185-97
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Zebrafish as an emerging model for studying complex brain disorders.Kalueff AV, Stewart AM, Gerlai R.Trends Pharmacol. Sci. 2014 Feb;35(2):63-75
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Chronic and acute alcohol administration induced neurochemical changes in the brain: comparison of distinct zebrafish populations.Chatterjee D, Shams S, Gerlai R.Amino Acids 2014 Apr;46(4):921-30
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Acute ethanol exposure induces behavioural differences in two zebrafish (Danio rerio) strains: a time course analysis.Pannia E, Tran S, Rampersad M, Gerlai R.Behav. Brain Res. 2014 Feb;259:174-85
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Strain dependent neurochemical changes induced by embryonic alcohol exposure in zebrafish.Mahabir S, Chatterjee D, Gerlai R.Neurotoxicol Teratol 2014 Jan-Feb;41:1-7
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Subcutaneous dye injection for marking and identification of individual adult zebrafish (Danio rerio) in behavioral studies.Cheung E, Chatterjee D, Gerlai R.Behav Res Methods 2014 Sep;46(3):619-24
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2013

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The role of body surface area in quantity discrimination in angelfish (Pterophyllum scalare).Gómez-Laplaza LM, Gerlai R.PLoS ONE 2013;8(12):e83880
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Individual differences in activity levels in zebrafish (Danio rerio).Tran S, Gerlai R.Behav. Brain Res. 2013 Nov;257:224-9
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Antipredatory behavior of zebrafish: adaptive function and a tool for translational research.Gerlai R.Evol Psychol 2013;11(3):591-605
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Time-course of behavioural changes induced by ethanol in zebrafish (Danio rerio).Tran S, Gerlai R.Behav. Brain Res. 2013 Sep;252:204-13
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Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond.Kalueff AV, Gebhardt M, Stewart AM, Cachat JM, Brimmer M, Chawla JS, Craddock C, Kyzar EJ, Roth A, Landsman S, Gaikwad S, Robinson K, Baatrup E, Tierney K, Shamchuk A, Norton W, Miller N, Nicolson T, Braubach O, Gilman CP, Pittman J, Rosemberg DB, Gerlai R, Echevarria D, Lamb E, Neuhauss SC, Weng W, Bally-Cuif L, Schneider H, .Zebrafish 2013 Mar;10(1):70-86
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Maturation of shoaling in two zebrafish strains: a behavioral and neurochemical analysis.Mahabir S, Chatterjee D, Buske C, Gerlai R.Behav. Brain Res. 2013 Jun;247:1-8
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Sight of conspecific images induces changes in neurochemistry in zebrafish.Saif M, Chatterjee D, Buske C, Gerlai R.Behav. Brain Res. 2013 Apr;243:294-9
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Effects of nicotine and alcohol on zebrafish (Danio rerio) shoaling.Miller N, Greene K, Dydinski A, Gerlai R.Behav. Brain Res. 2013 Mar;240:192-6
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Quantification abilities in angelfish (Pterophyllum scalare): the influence of continuous variables.Gómez-Laplaza LM, Gerlai R.Anim Cogn 2013 May;16(3):373-83
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2012

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From schooling to shoaling: patterns of collective motion in zebrafish (Danio rerio).Miller N, Gerlai R.PLoS ONE 2012;7(11):e48865
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Activity counts: the effect of swimming activity on quantity discrimination in fish.Gómez-Laplaza LM, Gerlai R.Front Psychol 2012;3:484
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Can zebrafish learn spatial tasks? An empirical analysis of place and single CS-US associative learning.Karnik I, Gerlai R.Behav. Brain Res. 2012 Aug;233(2):415-21
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Dopamine receptor antagonism disrupts social preference in zebrafish: a strain comparison study.Scerbina T, Chatterjee D, Gerlai R.Amino Acids 2012 Nov;43(5):2059-72
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Animated bird silhouette above the tank: acute alcohol diminishes fear responses in zebrafish.Luca RM, Gerlai R.Behav. Brain Res. 2012 Apr;229(1):194-201
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Using zebrafish to unravel the genetics of complex brain disorders.Gerlai R.Curr Top Behav Neurosci 2012;12:3-24
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In search of optimal fear inducing stimuli: Differential behavioral responses to computer animated images in zebrafish.Luca RM, Gerlai R.Behav. Brain Res. 2012 Jan;226(1):66-76
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Maturation of shoaling behavior is accompanied by changes in the dopaminergic and serotoninergic systems in zebrafish.Buske C, Gerlai R.Dev Psychobiol 2012 Jan;54(1):28-35
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2011

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Early embryonic ethanol exposure impairs shoaling and the dopaminergic and serotoninergic systems in adult zebrafish.Buske C, Gerlai R.Neurotoxicol Teratol 2011 Nov-Dec;33(6):698-707
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Shoaling in zebrafish: what we don't know.Miller NY, Gerlai R.Rev Neurosci 2011;22(1):17-25
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A small fish with a big future: zebrafish in behavioral neuroscience.Gerlai R.Rev Neurosci 2011;22(1):3-4
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Associative learning performance is impaired in zebrafish (Danio rerio) by the NMDA-R antagonist MK-801.Sison M, Gerlai R.Neurobiol Learn Mem 2011 Sep;96(2):230-7
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Associative learning in zebrafish (Danio rerio).Gerlai R.Methods Cell Biol. 2011;101:249-70
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Redefining membership in animal groups.Miller N, Gerlai R.Behav Res Methods 2011 Dec;43(4):964-70
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Spontaneous discrimination of small quantities: shoaling preferences in angelfish (Pterophyllum scalare).Gómez-Laplaza LM, Gerlai R.Anim Cogn 2011 Jul;14(4):565-74
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Behavioral performance altering effects of MK-801 in zebrafish (Danio rerio).Sison M, Gerlai R.Behav. Brain Res. 2011 Jul;220(2):331-7
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Shoaling develops with age in Zebrafish (Danio rerio).Buske C, Gerlai R.Prog. Neuropsychopharmacol. Biol. Psychiatry 2011 Aug;35(6):1409-15
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An automated predator avoidance task in zebrafish.Ahmed O, Seguin D, Gerlai R.Behav. Brain Res. 2011 Jan;216(1):166-71
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Chronic alcohol exposure induced gene expression changes in the zebrafish brain.Pan Y, Kaiguo M, Razak Z, Westwood JT, Gerlai R.Behav. Brain Res. 2011 Jan;216(1):66-76
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Can angelfish (Pterophyllum scalare) count? Discrimination between different shoal sizes follows Weber's law.Gómez-Laplaza LM, Gerlai R.Anim Cogn 2011 Jan;14(1):1-9
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2010

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High-throughput behavioral screens: the first step towards finding genes involved in vertebrate brain function using zebrafish.Gerlai R.Molecules 2010 Apr;15(4):2609-22
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Latent learning in zebrafish (Danio rerio).Gómez-Laplaza LM, Gerlai R.Behav. Brain Res. 2010 Apr;208(2):509-15
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Zebrafish antipredatory responses: a future for translational research?.Gerlai R.Behav. Brain Res. 2010 Mar;207(2):223-31
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Associative learning in zebrafish (Danio rerio) in the plus maze.Sison M, Gerlai R.Behav. Brain Res. 2010 Feb;207(1):99-104
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2009

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The synthetic substance hypoxanthine 3-N-oxide elicits alarm reactions in zebrafish (Danio rerio).Parra KV, Adrian JC, Gerlai R.Behav. Brain Res. 2009 Dec;205(2):336-41
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Zebrafish (Danio rerio) responds to the animated image of a predator: towards the development of an automated aversive task.Gerlai R, Fernandes Y, Pereira T.Behav. Brain Res. 2009 Aug;201(2):318-24
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High precision liquid chromatography analysis of dopaminergic and serotoninergic responses to acute alcohol exposure in zebrafish.Chatterjee D, Gerlai R.Behav. Brain Res. 2009 Jun;200(1):208-13
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Long-term behavioral changes in response to early developmental exposure to ethanol in zebrafish.Fernandes Y, Gerlai R.Alcohol. Clin. Exp. Res. 2009 Apr;33(4):601-9
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Shuttle box learning in zebrafish (Danio rerio).Pather S, Gerlai R.Behav. Brain Res. 2009 Jan;196(2):323-7
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2008

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Differences in acute alcohol-induced behavioral responses among zebrafish populations.Gerlai R, Ahmad F, Prajapati S.Alcohol. Clin. Exp. Res. 2008 Oct;32(10):1763-73
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Oscillations in shoal cohesion in zebrafish (Danio rerio).Miller NY, Gerlai R.Behav. Brain Res. 2008 Nov;193(1):148-51
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The social zebrafish: behavioral responses to conspecific, heterospecific, and computer animated fish.Saverino C, Gerlai R.Behav. Brain Res. 2008 Aug;191(1):77-87
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Sight of conspecifics as reward in associative learning in zebrafish (Danio rerio).Al-Imari L, Gerlai R.Behav. Brain Res. 2008 May;189(1):216-9
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Alarm substance induced behavioral responses in zebrafish (Danio rerio).Speedie N, Gerlai R.Behav. Brain Res. 2008 Mar;188(1):168-77
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Zebrafish (Danio rerio) responds differentially to stimulus fish: the effects of sympatric and allopatric predators and harmless fish.Bass SL, Gerlai R.Behav. Brain Res. 2008 Jan;186(1):107-17
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2007

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Quantification of shoaling behaviour in zebrafish (Danio rerio).Miller N, Gerlai R.Behav. Brain Res. 2007 Dec;184(2):157-66
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2006

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Effects of acute and chronic ethanol exposure on the behavior of adult zebrafish (Danio rerio).Gerlai R, Lee V, Blaser R.Pharmacol. Biochem. Behav. 2006 Dec;85(4):752-61
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Behavioral phenotyping in zebrafish: comparison of three behavioral quantification methods.Blaser R, Gerlai R.Behav Res Methods 2006 Aug;38(3):456-69
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Fishing for genes influencing vertebrate behavior: zebrafish making headway.Sison M, Cawker J, Buske C, Gerlai R.Lab Anim (NY) 2006 May;35(5):33-9
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2004

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Autism: a target of pharmacotherapies?.Gerlai R, Gerlai J.Drug Discov. Today 2004 Apr;9(8):366-74
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2003

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Zebra fish: an uncharted behavior genetic model.Gerlai R.Behav. Genet. 2003 Sep;33(5):461-8
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Autism: a large unmet medical need and a complex research problem.Gerlai J, Gerlai R.Physiol. Behav. 2003 Aug;79(3):461-70
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2002

Top
Hippocampal LTP and memory in mouse strains: is there evidence for a causal relationship?.Gerlai R.Hippocampus 2002;12(5):657-66
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Behavioral impairment of APP(V717F) mice in fear conditioning: is it only cognition?.Gerlai R, Fitch T, Bales KR, Gitter BD.Behav. Brain Res. 2002 Nov;136(2):503-9
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Phenomics: fiction or the future?.Gerlai R.Trends Neurosci. 2002 Oct;25(10):506-9
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Altered performance characteristics in cognitive tasks: comparison of the albino ICR and CD1 mouse strains.Adams B, Fitch T, Chaney S, Gerlai R.Behav. Brain Res. 2002 Jul;133(2):351-61
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EphB and NMDA receptors: components of synaptic plasticity coming together.Gerlai R.Trends Neurosci. 2002 Apr;25(4):180-1
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Force transducer-based movement detection in fear conditioning in mice: a comparative analysis.Fitch T, Adams B, Chaney S, Gerlai R.Hippocampus 2002;12(1):4-17
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Afraid of complications in gene targeting? Anxiety plays a role!.Gerlai R.Trends Neurosci. 2002 Mar;25(3):136
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Hippocampal dysfunction and behavioral deficit in the water maze in mice: an unresolved issue?.Gerlai RT, McNamara A, Williams S, Phillips HS.Brain Res. Bull. 2002 Jan;57(1):3-9
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