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CSB Departmental Seminar – Professor Adam Mott, UTSC

September 21 @ 11:00 am - 12:00 pm

CSB Departmental Seminar

Professor Adam Mott

University of Toronto, Scarborough Campus

Department of Biological Sciences

“Nature and Nurture of Tissue Resident Macrophages”

Friday September 21, 2018
11:00 a.m. – 12:00 p.m. at RW 432
Host:
Professor Darrell Desveaux
darrell.desveaux@utoronto.ca
Abstract:

To thrive, plants must be able to quickly recognize and respond to changing environmental conditions and pathogen attack. The perception of many signals is accomplished through the actions of members of the leucine-rich repeat receptor kinase (LRR-RK) family, of which there are 225 in Arabidopsis. Upon detection of an extracellular signal, these receptors physically interact to form signaling-competent structures able to integrate complex signals to guide plant defence and growth. Using a high-throughput interaction screen we determined the interactions between 200 of the LRR-RLKs from Arabidopsis. Using network analysis and community detection we have detected distinct, but interconnected, subnetworks that show evidence of specialization of biological activity and shown novel function for several previous unstudied receptors. In addition, we show that the overall network structure is critical for proper signaling responses, and disruptions can have unexpected consequences at a distance.

Details

Date:
September 21
Time:
11:00 am - 12:00 pm

Venue

Ramsay Wright Building, Room 432
25 Harbord St.
Toronto, ON M5S 3G5 Canada

Organizer

University of Toronto, Cell & Systems Biology