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CSB Special Seminar: Dr. Garciela Lorca, Department of Microbiology and Cell Science, University of Florida
May 2, 2017 @ 11:10 am - 12:10 pm
Host: Dr. Dinesh Christendat
Dr. Lorca is interested in the understanding the mechanisms that modulate the activity of one-component transcriptional regulators (TF). These proteins are involved in the regulation of the gene expression in response to a wide variety of intracellular and environmental signals. Her lab is particularly interested in the identification of those small signal molecules and how the small molecule/TF interactions can be modified/optimized. Using this strategy, the native molecule that modulate the activity of TFs belonging to the IclR, LysR and MarR families were identified. Using a similar approach, synthetic molecules that act as competitive inhibitors were identified and used as new antimicrobials for the treatment of infectious diseases.
Video Conferencing at UTM (DV3138) & UTSc (MW229)