Research in our department investigates the behaviour of cells – the fundamental units of life – in terms of molecular processes within and between cells. Both hypothesis-driven and discovery-based strategies are integrated to gain a mechanistic understanding of complex and highly dynamic cellular systems and how they govern the development, physiology, and evolution of organisms.

CSB embraces new methodologies and state-of-the art technologies. Its researchers use a wide range of cutting-edge tools to study the fundamental biological mechanisms that govern interactions at all levels of complexity, ranging from molecules to communities.

CSB has particular expertise in high-throughput functional genomics, structural and chemical biology, advanced imaging, computational, and physiological approaches. Our research also makes use of a variety of model prokaryotic and eukaryotic organisms and cultured mammalian cells, including stem cell models of differentiation.

Please select one of our research themes below to explore our diverse faculty and research programs!

Recent Publications

Camsap2a regulates actomyosin flow and Rab5ab-mediated macropinocytosis in the yolk cell during zebrafish epiboly

Wan H, Quibria S, Iu E, User SD, Plotnikov SV, Bruce AEE
2026, Development, 10.1242/dev.204843

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration

Iu E, Bogatch A, Deng W, Humphries JD, Yang C, Valencia FR, Li C, McCulloch CA, Tanentzapf G, Svitkina TM, Humphries MJ, Plotnikov SV
2026, Current Biology, 10.1016/j.cub.2026.01.024

Actomyosin cortex integration with complex plasma membrane topography in the early Drosophila embryo

Naidoo RK, Tam R, Harris TJ
2026, Journal of Cell Biology, 10.1083/jcb.202509151

All Publications

Latest News

Secrets of gene regulation during development probed with new tools by Professor Colette L. Picard

Professor Colette L. Picard is bringing her innovative skills in single cell genomics to the Department of Cell & Systems Biology (CSB) as a new…

Technical innovations in the Plotnikov lab reveal machinery behind cell migration in unprecedented detail

An international team led by a UofT lab has revealed a novel regulatory system behind cell migration and shown how the different parts work……

Professor Eyal Gruntman earns funding for cutting-edge equipment to probe the brains of flies

A new grant to Professor Eyal Gruntman from the Canadian Foundation for Innovation (CFI) will purchase a light-sheet microscope to speed up his…

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