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CSB Deptl Seminar: Prof. David Lovejoy, Cell & Systems Biology, University of Toronto

February 19, 2016 @ 2:00 pm - 3:00 pm

CSB Departmental Seminar

Prof. David Lovejoy
Cell & Systems Biology
University of Toronto

Adhesion G-protein Coupled Receptors: The Origin of
the Regulation
of Stress-associated Metabolism in the Metazoa”

Host: Prof. Maurice Ringuette

Refreshments will be served. All are welcome!
Video Conferencing at UTM (DV 4001) & UTSc (MW 229)

The teneurin-ADGRL (latrophilin) pairing is the only trans-synaptic adhesion system that is conserved between invertebrates and vertebrates. Both the teneurin ligand and ADGRL receptor ligand was the result of lateral gene transfer from prokaryotes to an early eukaryotic ancestor of metazoans. Through subsequent gene duplications both systems radiated throughout the Metazoa. At the distal extracellular tip of the teneurins lies a bioactive peptide termed the “teneurin C-terminal associated peptide” (TCAP). Evidence indicates that TCAP was once the payload of a prokaryotic polymorphic proteinaceous toxin but has evolved to become a progenitor of metabolic peptides in vertebrates.


February 19, 2016
2:00 pm - 3:00 pm
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Ramsay Wright Building, Room 432
25 Harbord St.
Toronto, ON M5S 3G5 Canada