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CSB Deptl Seminar: Prof. David Lovejoy, Cell & Systems Biology, University of Toronto
February 19, 2016 @ 2:00 pm - 3:00 pm
CSB Departmental Seminar
Prof. David Lovejoy
Cell & Systems Biology
University of Toronto
“Adhesion G-protein Coupled Receptors: The Origin of
the Regulation of Stress-associated Metabolism in the Metazoa”
Host: Prof. Maurice Ringuette
Refreshments will be served. All are welcome!
Video Conferencing at UTM (DV 4001) & UTSc (MW 229)
Abstract:
The teneurin-ADGRL (latrophilin) pairing is the only trans-synaptic adhesion system that is conserved between invertebrates and vertebrates. Both the teneurin ligand and ADGRL receptor ligand was the result of lateral gene transfer from prokaryotes to an early eukaryotic ancestor of metazoans. Through subsequent gene duplications both systems radiated throughout the Metazoa. At the distal extracellular tip of the teneurins lies a bioactive peptide termed the “teneurin C-terminal associated peptide” (TCAP). Evidence indicates that TCAP was once the payload of a prokaryotic polymorphic proteinaceous toxin but has evolved to become a progenitor of metabolic peptides in vertebrates.