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CSB Deptl Seminar: Prof. Patrick Laprise, Molecular Biology, Medical Biochemistry and Pathology/Oncology, Université Laval
December 4, 2015 @ 2:00 pm - 3:00 pm
CSB Departmental Seminar
Prof. Patrick Laprise
Molecular Biology, Medical Biochemistry
and Pathology/Oncology
Université Laval
“Molecular Mechanisms Orchestrating Epithelial Cell Polarity”
Friday, December 4, 2015 at 2 p.m.
Ramsay Wright Building, Room 432
Host: Prof. Dorothea Godt <d.godt@utoronto.ca>
Abstract:
The functions of epithelial cells rely on the asymmetric distribution of many cellular constituents—a structural organization referred to as epithelial polarity. The polarized architecture of epithelial cells also shapes tissues during development. The protein machinery establishing epithelial polarity is conserved from flies to humans, reflecting its significance for the physiology of metazoans. For instance, the protein Yurt (Yrt) is a critical regulator of epithelial cell polarity in both flies and mammals. Our general objective is to further define Yrt function and regulation to illuminate the protein network that establishes epithelial polarity, thereby providing a better understanding of the molecular mechanisms sustaining epithelial tissue morphogenesis and physiology. My presentation will cover our recent work highlighting post-translational regulation of Yrt activity, and defining the oligomeric interfaces of this protein.