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CSB Seminar: Peter Swain, University of Edinburgh
June 4, 2021 @ 11:00 am - 12:00 pm
Title: Using a push-pull system of repressors to match glucose transporters to extracellular glucose
Peter Swain
University of Edinburgh
Abstract: A common cellular task is to match gene expression dynamically to a range of concentrations of a regulatory molecule. Studying glucose transport in budding yeast, we determine mechanistically how such matching occurs for seven hexose transporters. By combining time-lapse microscopy with mathematical modelling, we find that levels of transporters are history-dependent and are regulated by a push-pull system comprising two types of repressors. I will argue that matching is favoured by a rate-affinity trade-off and that the regulatory system allows yeast to import glucose rapidly enough to starve competitors.
Friday, June 4, 2021 at 11:00am
https://utoronto.zoom.us/j/94049486250
Host: Alan Moses