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CSB Seminar: Prof. Jean Gariepy, Depts of Pharmaceutical Sciences and Medical Biophysics
November 28, 2014 @ 2:00 pm - 3:00 pm
CSB Departmental Seminar
Prof. Jean Gariepy
Depts of Pharmaceutical Sciences and Medical Biophysics
University of Toronto
SRI Research Chair in Biomolecular Engineering
Sunnybrook Research Institute
“Functional Aptamers, a New Class of Biotherapeutics”
Abstract:
Aptamers are short, synthetic single strand oligonucleotides that bind specifically and selectively to a given target. Aptamers are derived by an in vitro, PCR-based iterative process known as Systematic Evolution of Ligands by EXponential enrichment (SELEX). Our group has recently generated DNA aptamers that bind to well known druggable targets. Importantly, agonistic and antagonistic aptamers to these targets were identified using functional assays making them valuable as potential biotherapeutics. The concept behind aptamer searches and examples of derived aptamers with potent in vitro and in vivo activities will be discussed in this presentation.
Host: Prof. Maurice Ringuette
Video Conferencing at UTM (DV 4001) & UTSc (MW 229)