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CSB Seminar: Prof. Mikko Taipale, Dept of Medical Genetics, Donnelly Centre for Biomedical Research, University of Toronto
December 2, 2016 @ 2:00 pm - 3:00 pm
Cell & Systems Biology
Departmental Seminar
“Systematic Characterization of Human Chaperone/Client Interaction Networks”
Host: Prof. Maurice Ringuette <maurice.ringuette@utoronto.ca>
Abstract:
Chaperones are abundant, highly conserved cellular proteins that promote the folding and function of their substrate proteins (clients). In vivo, chaperones also associate with a large and diverse set of cofactors (cochaperones) that regulate their specificity and function. However, how these co=chaperones regulate protein folding and whether they have chaperone-independent biological functions is largely unknown. My lab is characterizing human chaperone/co-chaperone/client interaction networks with multiple functional proteomics approaches. Currently, our main focus is on the Hsp70/Hsp40 chaperone/co-chaperone network, which regulates thousands of diverse client proteins in all organisms.
Video Conferencing at UTM (DV3138) & UTSc (MW229)