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CSB Seminar: How to make microtubules and build the cytoskeleton

April 23, 2021 @ 11:00 am - 12:00 pm

How to make microtubules and build the cytoskeleton

Sabine Petry 

Associate Professor, Department of Molecular Biology  

Princeton University


“How does a cell construct its microtubule cytoskeleton? According to Feynman’s principle “what I cannot create, I do not understand”, my lab pursues this question by building the chromosome segregation machinery from scratch. I will first tell you how the microtubule framework is generated in a cell. Upon deciphering the function of the most important microtubule accessory proteins, I will present how we use those building blocks to reconstitute a spindle substructure in vitro and determine its building plan. Finally, I will outline how we combine spindle substructures like pieces of a puzzle to assemble and thereby understand a functioning spindle that segregates chromosomes.

By studying how the MT cytoskeleton is built, I hope to help explain how hundreds of proteins can self-assemble on the nm scale into a complex molecular machine 1000-fold larger than its constituents, a challenge for the biochemistry of the 21st century.”

Friday, April 23rd, 2021 at 11:00am


Host: Student invited speaker (Ernest Iu and Steven Chen)


April 23, 2021
11:00 am - 12:00 pm
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