CSB Seminar Series – Auinash Kalsotra, PhD – University of Illinois Urbana-Champaign
April 11 @ 11:00 am - 12:00 pm
CSB Departmental Seminar
Auinash Kalsotra, PhD
University of Illinois Urbana-Champaign
TITLE: Post-transcriptional control of cell plasticity in tissue development, regeneration, and disease
ABSTRACT: This seminar will focus on post-transcriptional mechanisms that affect the “quality” and “quantity” of RNAs produced in a cell-type- and context-dependent manner. First, I will describe the identification of a conserved developmentally regulated alternative splicing program that supports terminal differentiation, functional competence, and postnatal maturation of hepatocytes. Second, I will show evidence that following liver injury, this developmental splicing program is transiently redeployed to rewire a critical signaling pathway that enables proper liver regeneration. Third, I will demonstrate that in alcohol-associated liver disease, the sustained re-activation of this developmental program causes hepatocytes to shed adult functions and become more regenerative but threatens overall survival by populating the liver with functionally immature cells.
HOST: John Calarco
LOCATION: Cell and Systems Biology, 25 Harbord Street, Suite 432
LIVESTREAM LINK: https://csb.utoronto.ca/live-stream/