CSB Seminar Series – Daniele Canzio, PhD – UCSF, Weill Institute for Neurosciences

CSB Departmental Seminar

Daniele Canzio, PhD

UCSF, Weill Institute for Neurosciences

TITLE: How do neurons distinguish self from non-self? From genome architecture to brain architecture

ABSTRACT: My lab investigates how neurons distinguish self from non-self, a process critical for the establishment of appropriate neural wiring patterns during brain development. To tell each other apart and avoid self, neurons must express unique protein “barcodes” on their surfaces which confer individual cells molecular identities. We are particularly interested in the role of genome architecture and epigenetic gene silencing in the generation of the transcriptional diversity underlying the barcoding strategy of mammalian neurons to self-avoid. We are also investigating the mechanisms by which, once expressed, these protein barcodes function to mediate neural self-avoidance.

HOST: Student invitee – Ernest Lang, Calarco Lab & Linda Li, Saltzman Lab

LOCATION: Cell and Systems Biology, 25 Harbord Street, Suite 432

LIVESTREAM LINK: https://csb.utoronto.ca/live-stream/