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CSB Seminar Series – Franz Weber – University of Pennsylvania

October 28, 2022 @ 11:00 am - 12:00 pm

TITLE: Medullary control of REM sleep and pontine waves

Professor Franz Weber

Department of Neuroscience

University of Pennsylvania

ABSTRACT: Rapid-eye-movement (REM) sleep is a distinct behavioral state associated with vivid dreaming and memory processing. Phasic bursts of electrical activity, measurable as spike-like pontine (P)-waves, are a hallmark of REM sleep implicated in memory consolidation. However, the brainstem circuits regulating P-waves, and their interactions with circuits generating REM sleep, remain largely unknown. Here, we show that an excitatory population of dorsomedial medulla (dmM) neurons expressing corticotropin-releasing-hormone (CRH) regulates both REM sleep and P-waves. Calcium imaging showed that dmM CRH neurons are selectively activated during REM sleep and recruited during P-waves, and opto- and chemogenetic experiments revealed that this population promotes REM sleep. Chemogenetic manipulation also induced prolonged changes in P-wave frequency, while brief optogenetic activation reliably triggered P-waves along with transiently accelerated theta oscillations in the electroencephalogram (EEG). Together, these findings anatomically and functionally delineate a common medullary hub for the regulation of both REM sleep and P-waves.

HOST: John Peever

LOCATION: Cell and Systems Biology, 25 Harbord Street, Suite 432

Live Stream Link: 

Live Stream


October 28, 2022
11:00 am - 12:00 pm
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