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CSB Seminar Series – Julien Berro – Yale University

April 29 @ 11:00 am - 12:00 pm

TITLE: Measuring molecular forces during clathrin-mediated endocytosis

Professor Julien Berro
Department of Molecular Biophysics & Biochemistry, Department of Cell Biology
Yale University

Clathrin-mediated endocytosis consists of the formation of a vesicle out of a flat membrane in eukaryotic cells. Actin dynamics produces the forces required to invaginate the membrane and pinch it off into a vesicle when membrane tension or turgor pressure are high. However, how much force is produced at the molecular level and how the actin meshwork produces forces has remained elusive, because endocytic structures are transient, out of equilibrium, and diffraction limited. In this seminar, I will present new molecular force sensors our lab recently developed to measure forces in the 3 to 20 pN range on individual molecules in vivo. Application of these force sensors to endocytosis demonstrated that forces are collected and redistributed within the endocytic machinery.

HOST: Tony Harris

LOCATION: Sidney Smith Hall, Room 2125 / Virtual

Zoom ID and passcode:

https://utoronto.zoom.us/j/87447422547

Meeting ID: 874 4742 2547

Passcode: 050579

Details

Date:
April 29
Time:
11:00 am - 12:00 pm
Event Category:

Venue

Sidney Smith Hall, Room 2125
100 St. George Street
Toronto, Ontario M5S 3G3
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