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CSB Special Seminar: Dr. Deborah Winter, Dept of Immunology, Weizmann Institute of Science, Israel

March 4, 2015 @ 1:00 pm - 2:00 pm

CSB Special Seminar

Dr. Deborah Winter
Department of Immunology
Weizmann Institute of Science, Israel

“Nature vs. Nurture: The Influence of Environment on the Macrophage Chromatin Landscape”

Wednesday, March 4, 2015 at 1 p.m.
CCBR Black Seminar Room
160 College Street
Macrophages are critical for innate immune defense and also control organ homeostasis in a tissue-specific manner. They provide a fitting model to study the impact of ontogeny and microenvironment on chromatin state and whether chromatin modifications contribute to macrophage identity. Here, we profile the dynamics of four histone modifications across seven tissue-resident macrophage populations. We identify 12,743 macrophage-specific enhancers and establish that tissue-resident macrophages have distinct enhancer landscapes beyond what can be explained by developmental origin. Combining our enhancer catalog with gene expression profiles and open chromatin regions, we show that a combination of tissue- and lineage-specific transcription factors form the regulatory networks controlling chromatin specification in tissue-resident macrophages. The environment is capable of shaping the chromatin landscape of transplanted bone marrow precursors, and even differentiated macrophages can be reprogrammed when transferred into a new microenvironment. These results provide a comprehensive view of macrophage regulatory landscape and highlight the importance of the microenvironment, along with pioneer factors in orchestrating identity and plasticity.
Co-hosted by Gary Bader and Nicholas Provart
If you wish to meet with the speaker, please contact nicholas.provart@utoronto.ca
Recent publication: Lavin/Winter et al., Cell http://dx.doi.org/10.1016/j.cell.2014.11.018


March 4, 2015
1:00 pm - 2:00 pm
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