CSB Special Seminar: Dr. Gregory Emery, IRIC-University of Montreal

During cell division, the site of cytokinesis has to be precisely defined to ensure normal mitosis. In recent years, our understanding of the mechanisms ensuring the proper distribution of the cytokinetic machinery has significantly improved, yet the role and regulation of several molecules of the vesicular trafficking machinery in establishing the cytokinesis furrow and the abscission site is still under investigation. Here we have identify an interaction between 14-3-3 and Rip11, the sole Drosophila ortholog of the Rab11 class I family of effectors (Rab11-FIP1, 2 and 5), and we have found that it plays an important role in the distribution of key regulators of cytokinesis. In addition, recent developments concerning our work on the regulation of cell-cell communication during collective cell migration will also be discussed.