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MSc Exit Seminar – Bardia Nouriziabari (Takehara lab)

September 22, 2016 @ 2:10 pm - 2:40 pm

MSc Exit Seminar

Thursday September 22nd, 2:10 pm – Earth Sciences Centre, Rm. 3043


Bardia Nouriziabari (Takehara lab)


ERP-based detection of brain pathology in rat models for preclinical Alzheimer’s disease”




Early pathological features of Alzheimer’s disease (AD) include the accumulation of hyperphosphorylated tau protein (HP-tau) in the entorhinal cortex and progressive loss of basal forebrain (BF) cholinergic neurons. These pathologies are known to remain asymptomatic for many years before AD is clinically diagnosed; however, they may induce aberrant brain processing which can be captured as an abnormality in event-related potentials (ERPs). Here, we examined cortical ERPs while a differential associative learning paradigm was applied to adult male rats with entorhinal HP-tau, pharmacological blockade of muscarinic acetylcholine receptors, or both conditions. Despite no impairment in differential associative and reversal learning, each pathological feature induced distinct abnormality in cortical ERPs to an extent that was sufficient for machine classifiers to accurately detect a specific type of pathology based on these ERP features. These results highlight a potential use of ERPs during differential associative learning as a biomarker for asymptomatic AD pathology.



September 22, 2016
2:10 pm - 2:40 pm
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