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MSc Exit Seminar – Mouska Patang (Buck Lab)

November 13, 2020 @ 11:00 am - 11:30 pm

H2S as a potential O2 sensor in C. picta cerebrocortex  


The freshwater Western painted turtle, Chrysemys picta, is one of the most anoxia-tolerant vertebrates able to withstand months of anoxic conditions under ice-covered lakes. The turtle demonstrates remarkable recovery upon reoxygenation without sustaining organ damage associated with oxidative stress. It owes its winter survival to metabolic suppression, enhanced glycogen stores and proton buffering. Our recent work of pyramidal mitochondrial membrane potential depolarization and mitochondrial Ca2+ release has rendered the mitochondria a possible oxygen sensor in turtle neurons. However, the initial signaling molecule remains unknown. We speculate hydrogen sulfide (H2S) to act as a molecular oxygen sensor in neurons by its action on Ca2+ channels during anoxic stress. I have demonstrated an anoxia-dependent H2S increase (~40%), and a H2S-induced Ca2+ increase (~3%) directly via exogenous Na2S and indirectly via inhibition of the H2S synthesizing enzymes. Thus, we postulate H2S to have retained its primordial significance by switching from its role as a final electron acceptor 4Bya, to an oxygen sensor 2.5Bya.

Join Zoom Meeting:

Friday, November 13th, 2020 at 11:00am


Meeting ID: 830 8971 1556

Host: Leslie Buck (les.buck@utoronto.ca)


November 13, 2020
11:00 am - 11:30 pm