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PhD Transfer Seminar – Linda Li (Saltzman Lab)
June 11, 2021 @ 1:00 pm - 1:30 pm
Investigating the role of C. elegans heterochromatin readers in chromatin and small RNA regulation
Abstract
Chromatin and small RNA pathways ensure proper transcription regulation, which is essential for both somatic development and maintenance of germline integrity across generations. Small non-coding RNAs in the nuclear RNA interference (RNAi) pathway can induce both heritable co-transcriptional silencing and heterochromatinization at target genomic loci. However, the molecular pathways and factors involved in the crosstalk between chromatin and RNAi regulation remain to be fully explored. My proposed research investigates how the interplay between heterochromatin and small RNA pathways affects local and genome-wide chromatin landscape. I will study the molecular function of C. elegans chromodomain-containing (CEC) proteins, CEC-3 and CEC-6, as they can recognize heterochromatin-associated histone modifications and participate in restricting transgenerational RNAi-induced gene silencing. I will also establish an in vivo protein recruitment system to test for protein function in gene repression and chromatin regulation through altering histone modifications. Together, my work will further the understanding of chromatin regulation associated with nuclear RNAi and histone modifications.
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Join Zoom Meeting
https://utoronto.zoom.us/j/89295332990
Meeting ID: 892 9533 2990
Host: Arneet Saltzman (arneet.saltzman@utoronto.ca)
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