David A. Lovejoy
Professor Emeritus
Campus
St. George (downtown)
CSB Appointment
Emeritus
Research Areas
Animal Biology, Biotechnology, Cell Biology, Evolutionary Biology, Neurobiology, Physiology
Education
Ph.D. University of Victoria
B.Sc. University of Alberta
Primary Undergraduate Department
Cell & Systems Biology
Graduate Programs
Cell & Systems Biology
Chemical & Physical Sciences
Academic or Administrative Appointments
Chair, University Animal Care Committee
Research Description
Our research program is focused on the actions of three families of peptide hormones that encompass metabolism, stress and reproduction. These include 1) teneurin C-terminal associated peptide family; 2) Corticotropin-releasing hormone family, and 3) gonadotropin releasing hormone family. Our interest is how paralogous expansion of stress and metabolism based peptides act to regulate reproduction, growth and behaviour. Current studies utilize mammal, fish and tunicate models to provide and understanding how these systems evolve in vertebrates. Other studies are aimed at developing new approaches for the treatment of human stress associated pathology in the area of neurological, metabolic and fertility disorders.
Contact Information
Office Phone: 416-946-7259
Office: RW305B
Lab: RW304/RW305
Lab Phone: 416-978-2483
Email
Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada
Publications
2014
Repeated intravenous administrations of teneurin-C terminal associated peptide (TCAP)-1 attenuates reinstatement of cocaine seeking by corticotropin-releasing factor (CRF) in rats
Erb S, McPhee M, Brown ZJ, Kupferschmidt DA, Song L, Lovejoy DA
2014, Behavioural brain research, 269, 1-5, 24768621
Molecular evolution of GPCRs: CRH/CRH receptors
Lovejoy DA, Chang BS, Lovejoy NR, del Castillo J
2014, Journal of molecular endocrinology, 52, T43-60, 24711645
2013
Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss)
Ortega VA, Lovejoy DA, Bernier NJ
2013, Frontiers in neuroscience, 7, 196, 24194695
C-terminal region of teneurin-1 co-localizes with the dystroglycan complex in adult mouse testes and regulates testicular size and testosterone production
Chand D, Colacci M, Dixon K, Kollara A, Brown TJ, Lovejoy DA
2014, Histochemistry and cell biology, 141, 191-211, 24154551
Evolution and phylogeny of the corticotropin-releasing factor (CRF) family of peptides: expansion and specialization in the vertebrates
Lovejoy DA, de Lannoy L
2013, Journal of chemical neuroanatomy, 54, 50-6, 24076419
Teneurin C-terminal associated peptides (TCAP): modulators of corticotropin-releasing factor (CRF) physiology and behavior
Chen Y, Xu M, De Almeida R, Lovejoy DA
2013, Frontiers in neuroscience, 7, 166, 24062636
Systems approaches to genomic and epigenetic inter-regulation of peptide hormones in stress and reproduction
Lovejoy DA, Barsyte-Lovejoy D
2013, Progress in biophysics and molecular biology, 113, 375-86, 23500148
Origin of chordate peptides by horizontal protozoan gene transfer in early metazoans and protists: evolution of the teneurin C-terminal associated peptides (TCAP)
Chand D, de Lannoy L, Tucker R, Lovejoy DA
2013, General and comparative endocrinology, 188, 144-50, 23453965
2012
C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells
Chand D, Casatti CA, de Lannoy L, Song L, Kollara A, Barsyte-Lovejoy D, Brown TJ, Lovejoy DA
2013, Molecular and cellular neurosciences, 52, 38-50, 23026563
2011
Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells
Ng T, Chand D, Song L, Al Chawaf A, Watson JD, Boutros PC, Belsham DD, Lovejoy DA
2012, Regulatory peptides, 174, 79-89, 22209827
Modulation of neuroplastic changes and corticotropin-releasing factor-associated behavior by a phylogenetically ancient and conserved peptide family
Tan LA, Chand D, De Almeida R, Xu M, De Lannoy L, Lovejoy DA
2012, General and comparative endocrinology, 176, 309-13, 22138219
Interfacial behavior of immortalized hypothalamic mouse neurons detected by acoustic wave propagation
Cheung S, Fick LJ, Belsham DD, Lovejoy DA, Thompson M
2011, The Analyst, 136, 4412-21, 21866285
Teneurin C-terminal associated peptide (TCAP)-1 modulates dendritic morphology in hippocampal neurons and decreases anxiety-like behaviors in rats
Tan LA, Al Chawaf A, Vaccarino FJ, Boutros PC, Lovejoy DA
2011, Physiology & behavior, 104, 199-204, 21411044
Stress and reproduction: controversies and challenges
Chand D, Lovejoy DA
2011, General and comparative endocrinology, 171, 253-7, 21362426
Identification of members of the gonadotropin-releasing hormone (GnRH), corticotropin-releasing factor (CRF) families in the genome of the holocephalan, Callorhinchus milii (elephant shark)
Nock TG, Chand D, Lovejoy DA
2011, General and comparative endocrinology, 171, 237-44, 21310155
Teneurin C-terminal associated peptide-1 blocks the effects of corticotropin-releasing factor on reinstatement of cocaine seeking and on cocaine-induced behavioural sensitization
Kupferschmidt DA, Lovejoy DA, Rotzinger S, Erb S
2011, British journal of pharmacology, 162, 574-83, 20883474
2009
Behavioral effects of neuropeptides in rodent models of depression and anxiety
Rotzinger S, Lovejoy DA, Tan LA
2010, Peptides, 31, 736-56, 20026211
Characterization of a corticotropin-releasing factor (CRF)/diuretic hormone-like peptide from tunicates: insight into the origins of the vertebrate CRF family
Lovejoy DA, Barsyte-Lovejoy D
2010, General and comparative endocrinology, 165, 330-6, 19646444
Structural evolution of urotensin-I: reflections of life before corticotropin releasing factor
Lovejoy DA
2009, General and comparative endocrinology, 164, 15-9, 19393654
Evolution of complementary peptide systems: teneurin C-terminal-associated peptides and corticotropin-releasing factor superfamilies
Lovejoy DA, Rotzinger S, Barsyte-Lovejoy D
2009, Annals of the New York Academy of Sciences, 1163, 215-20, 19456342
Teneurin C-terminal associated peptide (TCAP)-1 attenuates corticotropin-releasing factor (CRF)-induced c-Fos expression in the limbic system and modulates anxiety behavior in male Wistar rats
Tan LA, Xu K, Vaccarino FJ, Lovejoy DA, Rotzinger S
2009, Behavioural brain research, 201, 198-206, 19428634
2007
Repeated intracerebral teneurin C-terminal associated peptide (TCAP)-1 injections produce enduring changes in behavioral responses to corticotropin-releasing factor (CRF) in rat models of anxiety
Tan LA, Xu K, Vaccarino FJ, Lovejoy DA, Rotzinger S
2008, Behavioural brain research, 188, 195-200, 18082275
Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells
Trubiani G, Al Chawaf A, Belsham DD, Barsyte-Lovejoy D, Lovejoy DA
2007, Brain research, 1176, 27-36, 17900539
Corticotropin-releasing factor (CRF)-induced behaviors are modulated by intravenous administration of teneurin C-terminal associated peptide-1 (TCAP-1)
Al Chawaf A, Xu K, Tan L, Vaccarino FJ, Lovejoy DA, Rotzinger S
2007, Peptides, 28, 1406-15, 17644218
2006
Teneurin C-terminal associated peptides: an enigmatic family of neuropeptides with structural similarity to the corticotropin-releasing factor and calcitonin families of peptides
Lovejoy DA, Al Chawaf A, Cadinouche MZ
2006, General and comparative endocrinology, 148, 299-305, 16524574
Phylogeny of the corticotropin-releasing factor family of peptides in the metazoa
Lovejoy DA, Jahan S
2006, General and comparative endocrinology, 146, 1-8, 16472809
2005
Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity
Wang L, Rotzinger S, Al Chawaf A, Elias CF, Barsyte-Lovejoy D, Qian X, Wang NC, De Cristofaro A, Belsham D, Bittencourt JC, Vaccarino F, Lovejoy DA
2005, Brain research. Molecular brain research, 133, 253-65, 15710242
Gonadotropin-releasing hormone: gene evolution, expression, and regulation
Belsham DD, Lovejoy DA
2005, Vitamins and hormones, 71, 59-94, 16112265
2004
Cloning and characterization of teneurin C-terminus associated peptide (TCAP)-3 from the hypothalamus of an adult rainbow trout (Oncorhynchus mykiss)
Qian X, Barsyte-Lovejoy D, Wang L, Chewpoy B, Gautam N, Al Chawaf A, Lovejoy DA
2004, General and comparative endocrinology, 137, 205-16, 15158132
2003
Urocortin in the central nervous system of a primate (Cebus apella): sequencing, immunohistochemical, and hybridization histochemical characterization
Vasconcelos LA, Donaldson C, Sita LV, Casatti CA, Lotfi CF, Wang L, Cadinouche MZ, Frigo L, Elias CF, Lovejoy DA, Bittencourt JC
2003, The Journal of comparative neurology, 463, 157-75, 12815753