Professor David A. Lovejoy

David A. Lovejoy

Professor Emeritus


St. George (downtown)

CSB Appointment


Research Areas

Animal Biology, Biotechnology, Cell Biology, Evolutionary Biology, Neurobiology, Physiology


Ph.D. University of Victoria
B.Sc. University of Alberta

Primary Undergraduate Department

Cell & Systems Biology

Graduate Programs

Cell & Systems Biology
Chemical & Physical Sciences

Academic or Administrative Appointments

Chair, University Animal Care Committee

Research Description

Our research program is focused on the actions of three families of peptide hormones that encompass metabolism, stress and reproduction. These include 1) teneurin C-terminal associated peptide family; 2) Corticotropin-releasing hormone family, and 3) gonadotropin releasing hormone family. Our interest is how paralogous expansion of stress and metabolism based peptides act to regulate reproduction, growth and behaviour. Current studies utilize mammal, fish and tunicate models to provide and understanding how these systems evolve in vertebrates. Other studies are aimed at developing new approaches for the treatment of human stress associated pathology in the area of neurological, metabolic and fertility disorders.

Contact Information

Office Phone: 416-946-7259
Office: RW305B
Lab: RW304/RW305
Lab Phone: 416-978-2483

Mailing Address

Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5



Repeated intravenous administrations of teneurin-C terminal associated peptide (TCAP)-1 attenuates reinstatement of cocaine seeking by corticotropin-releasing factor (CRF) in rats

Erb S, McPhee M, Brown ZJ, Kupferschmidt DA, Song L, Lovejoy DA
2014, Behavioural brain research, 269, 1-5, 24768621

Molecular evolution of GPCRs: CRH/CRH receptors

Lovejoy DA, Chang BS, Lovejoy NR, del Castillo J
2014, Journal of molecular endocrinology, 52, T43-60, 24711645

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Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss)

Ortega VA, Lovejoy DA, Bernier NJ
2013, Frontiers in neuroscience, 7, 196, 24194695

C-terminal region of teneurin-1 co-localizes with the dystroglycan complex in adult mouse testes and regulates testicular size and testosterone production

Chand D, Colacci M, Dixon K, Kollara A, Brown TJ, Lovejoy DA
2014, Histochemistry and cell biology, 141, 191-211, 24154551

Evolution and phylogeny of the corticotropin-releasing factor (CRF) family of peptides: expansion and specialization in the vertebrates

Lovejoy DA, de Lannoy L
2013, Journal of chemical neuroanatomy, 54, 50-6, 24076419

Teneurin C-terminal associated peptides (TCAP): modulators of corticotropin-releasing factor (CRF) physiology and behavior

Chen Y, Xu M, De Almeida R, Lovejoy DA
2013, Frontiers in neuroscience, 7, 166, 24062636

Systems approaches to genomic and epigenetic inter-regulation of peptide hormones in stress and reproduction

Lovejoy DA, Barsyte-Lovejoy D
2013, Progress in biophysics and molecular biology, 113, 375-86, 23500148

Origin of chordate peptides by horizontal protozoan gene transfer in early metazoans and protists: evolution of the teneurin C-terminal associated peptides (TCAP)

Chand D, de Lannoy L, Tucker R, Lovejoy DA
2013, General and comparative endocrinology, 188, 144-50, 23453965

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C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells

Chand D, Casatti CA, de Lannoy L, Song L, Kollara A, Barsyte-Lovejoy D, Brown TJ, Lovejoy DA
2013, Molecular and cellular neurosciences, 52, 38-50, 23026563

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Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells

Ng T, Chand D, Song L, Al Chawaf A, Watson JD, Boutros PC, Belsham DD, Lovejoy DA
2012, Regulatory peptides, 174, 79-89, 22209827

Modulation of neuroplastic changes and corticotropin-releasing factor-associated behavior by a phylogenetically ancient and conserved peptide family

Tan LA, Chand D, De Almeida R, Xu M, De Lannoy L, Lovejoy DA
2012, General and comparative endocrinology, 176, 309-13, 22138219

Interfacial behavior of immortalized hypothalamic mouse neurons detected by acoustic wave propagation

Cheung S, Fick LJ, Belsham DD, Lovejoy DA, Thompson M
2011, The Analyst, 136, 4412-21, 21866285

Teneurin C-terminal associated peptide (TCAP)-1 modulates dendritic morphology in hippocampal neurons and decreases anxiety-like behaviors in rats

Tan LA, Al Chawaf A, Vaccarino FJ, Boutros PC, Lovejoy DA
2011, Physiology & behavior, 104, 199-204, 21411044

Stress and reproduction: controversies and challenges

Chand D, Lovejoy DA
2011, General and comparative endocrinology, 171, 253-7, 21362426

Identification of members of the gonadotropin-releasing hormone (GnRH), corticotropin-releasing factor (CRF) families in the genome of the holocephalan, Callorhinchus milii (elephant shark)

Nock TG, Chand D, Lovejoy DA
2011, General and comparative endocrinology, 171, 237-44, 21310155

Teneurin C-terminal associated peptide-1 blocks the effects of corticotropin-releasing factor on reinstatement of cocaine seeking and on cocaine-induced behavioural sensitization

Kupferschmidt DA, Lovejoy DA, Rotzinger S, Erb S
2011, British journal of pharmacology, 162, 574-83, 20883474

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Behavioral effects of neuropeptides in rodent models of depression and anxiety

Rotzinger S, Lovejoy DA, Tan LA
2010, Peptides, 31, 736-56, 20026211

Characterization of a corticotropin-releasing factor (CRF)/diuretic hormone-like peptide from tunicates: insight into the origins of the vertebrate CRF family

Lovejoy DA, Barsyte-Lovejoy D
2010, General and comparative endocrinology, 165, 330-6, 19646444

Structural evolution of urotensin-I: reflections of life before corticotropin releasing factor

Lovejoy DA
2009, General and comparative endocrinology, 164, 15-9, 19393654

Evolution of complementary peptide systems: teneurin C-terminal-associated peptides and corticotropin-releasing factor superfamilies

Lovejoy DA, Rotzinger S, Barsyte-Lovejoy D
2009, Annals of the New York Academy of Sciences, 1163, 215-20, 19456342

Teneurin C-terminal associated peptide (TCAP)-1 attenuates corticotropin-releasing factor (CRF)-induced c-Fos expression in the limbic system and modulates anxiety behavior in male Wistar rats

Tan LA, Xu K, Vaccarino FJ, Lovejoy DA, Rotzinger S
2009, Behavioural brain research, 201, 198-206, 19428634

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Repeated intracerebral teneurin C-terminal associated peptide (TCAP)-1 injections produce enduring changes in behavioral responses to corticotropin-releasing factor (CRF) in rat models of anxiety

Tan LA, Xu K, Vaccarino FJ, Lovejoy DA, Rotzinger S
2008, Behavioural brain research, 188, 195-200, 18082275

Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells

Trubiani G, Al Chawaf A, Belsham DD, Barsyte-Lovejoy D, Lovejoy DA
2007, Brain research, 1176, 27-36, 17900539

Corticotropin-releasing factor (CRF)-induced behaviors are modulated by intravenous administration of teneurin C-terminal associated peptide-1 (TCAP-1)

Al Chawaf A, Xu K, Tan L, Vaccarino FJ, Lovejoy DA, Rotzinger S
2007, Peptides, 28, 1406-15, 17644218

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Teneurin C-terminal associated peptides: an enigmatic family of neuropeptides with structural similarity to the corticotropin-releasing factor and calcitonin families of peptides

Lovejoy DA, Al Chawaf A, Cadinouche MZ
2006, General and comparative endocrinology, 148, 299-305, 16524574

Phylogeny of the corticotropin-releasing factor family of peptides in the metazoa

Lovejoy DA, Jahan S
2006, General and comparative endocrinology, 146, 1-8, 16472809

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Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity

Wang L, Rotzinger S, Al Chawaf A, Elias CF, Barsyte-Lovejoy D, Qian X, Wang NC, De Cristofaro A, Belsham D, Bittencourt JC, Vaccarino F, Lovejoy DA
2005, Brain research. Molecular brain research, 133, 253-65, 15710242

Gonadotropin-releasing hormone: gene evolution, expression, and regulation

Belsham DD, Lovejoy DA
2005, Vitamins and hormones, 71, 59-94, 16112265

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Cloning and characterization of teneurin C-terminus associated peptide (TCAP)-3 from the hypothalamus of an adult rainbow trout (Oncorhynchus mykiss)

Qian X, Barsyte-Lovejoy D, Wang L, Chewpoy B, Gautam N, Al Chawaf A, Lovejoy DA
2004, General and comparative endocrinology, 137, 205-16, 15158132

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Urocortin in the central nervous system of a primate (Cebus apella): sequencing, immunohistochemical, and hybridization histochemical characterization

Vasconcelos LA, Donaldson C, Sita LV, Casatti CA, Lotfi CF, Wang L, Cadinouche MZ, Frigo L, Elias CF, Lovejoy DA, Bittencourt JC
2003, The Journal of comparative neurology, 463, 157-75, 12815753

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