Elizabeth A. Edwards
Professor
Campus
St. George (downtown)
CSB Appointment
Cross
Research Areas
Bioinformatics / Computational Biology, Biotechnology, Genetics / Genomics, Metabolomics, Microbiology, Proteomics
Education
Ph.D. Stanford 1993
M. Eng. McGill 1985
B. Eng. McGill 1983
Titles and Honors
Canada Research Chair (tier 1) in Anaerobic Biotechnology, 2014
Fellow, Royal Society of Canada, 2012
Fellow, Canadian Academy of Engineering 2011
Fellow, AAAS, 2011
Killam Research Fellowship, 2008-2010
Primary Undergraduate Department
Chemical Engineering & Applied Chemistry
Graduate Programs
Cell & Systems Biology
Genome Biology & Bioinformatics
Academic or Administrative Appointments
Director, BioZone Centre for Applied Bioscience and Bioengineering Research
Research Description
Contact Information
Office Phone: 416-946-3506
Office: WB420D
Lab: WB311
Lab Phone: 416-978-4222
Email
Mailing Address
Department of Chemical Engineering & Applied Chemistry
University of Toronto
200 College St.
Toronto, ON M5S 3E5
Canada
Publications
2014
Bioremediation of chlorinated ethenes in fractured bedrock and associated changes in dechlorinating and nondechlorinating microbial populations
Pérez-de-Mora A, Zila A, McMaster ML, Edwards EA
2014, Environmental science & technology, 48, 5770-9, 24724903
Metatranscriptome of an anaerobic benzene-degrading, nitrate-reducing enrichment culture reveals involvement of carboxylation in benzene ring activation
Luo F, Gitiafroz R, Devine CE, Gong Y, Hug LA, Raskin L, Edwards EA
2014, Applied and environmental microbiology, 80, 4095-107, 24795366
New insights into Dehalococcoides mccartyi metabolism from a reconstructed metabolic network-based systems-level analysis of D. mccartyi transcriptomes
Islam MA, Waller AS, Hug LA, Provart NJ, Edwards EA, Mahadevan R
2014, PloS one, 9, e94808, 24733489
Bioaugmentation with distinct Dehalobacter strains achieves chloroform detoxification in microcosms
Justicia-Leon SD, Higgins S, Mack EE, Griffiths DR, Tang S, Edwards EA, Löffler FE
2014, Environmental science & technology, 48, 1851-8, 24392834
2013
Complete Genome Sequence of Bacteroidales Strain CF from a Chloroform-Dechlorinating Enrichment Culture
Tang S, Edwards EA
2013, Genome announcements, 1, 24356833
Diversity of reductive dehalogenase genes from environmental samples and enrichment cultures identified with degenerate primer PCR screens
Hug LA, Edwards EA
2013, Frontiers in microbiology, 4, 341, 24312087
Meeting report: 1st international functional metagenomics workshop may 7-8, 2012, st. Jacobs, ontario, Canada
Engel K, Ashby D, Brady SF, Cowan DA, Doemer J, Edwards EA, Fiebig K, Martens EC, McCormac D, Mead DA, Miyazaki K, Moreno-Hagelsieb G, O'Gara F, Reid A, Rose DR, Simonet P, Sjöling S, Smalla K, Streit WR, Tedman-Jones J, Valla S, Wellington EM, Wu CC, Liles MR, Neufeld JD, Sessitsch A, Charles TC
2013, Standards in genomic sciences, 8, 106-11, 23961315
Overview of organohalide-respiring bacteria and a proposal for a classification system for reductive dehalogenases
Hug LA, Maphosa F, Leys D, Löffler FE, Smidt H, Edwards EA, Adrian L
2013, Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368, 20120322, 23479752
Identification of Dehalobacter reductive dehalogenases that catalyse dechlorination of chloroform, 1,1,1-trichloroethane and 1,1-dichloroethane
Tang S, Edwards EA
2013, Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368, 20120318, 23479748
Anaerobic conversion of chlorobenzene and benzene to CH4 and CO2 in bioaugmented microcosms
Liang X, Devine CE, Nelson J, Sherwood Lollar B, Zinder S, Edwards EA
2013, Environmental science & technology, 47, 2378-85, 23360185
2012
Semi-automatic in silico gap closure enabled de novo assembly of two Dehalobacter genomes from metagenomic data
Tang S, Gong Y, Edwards EA
2012, PloS one, 7, e52038, 23284863
Paediatric home ventilatory support: changing milieu, proactive solutions
Edwards EA, Nixon GM,
2013, Journal of paediatrics and child health, 49, 13-8, 23252372
Functional characterization of reductive dehalogenases by using blue native polyacrylamide gel electrophoresis
Tang S, Chan WW, Fletcher KE, Seifert J, Liang X, Löffler FE, Edwards EA, Adrian L
2013, Applied and environmental microbiology, 79, 974-81, 23204411
Large carbon isotope fractionation during biodegradation of chloroform by Dehalobacter cultures
Chan CC, Mundle SO, Eckert T, Liang X, Tang S, Lacrampe-Couloume G, Edwards EA, Lollar BS
2012, Environmental science & technology, 46, 10154-60, 22900494
Comparative metagenomics of three Dehalococcoides-containing enrichment cultures: the role of the non-dechlorinating community
Hug LA, Beiko RG, Rowe AR, Richardson RE, Edwards EA
2012, BMC genomics, 13, 327, 22823523
Discovery of a trans-dichloroethene-respiring Dehalogenimonas species in the 1,1,2,2-tetrachloroethane-dechlorinating WBC-2 consortium
Manchester MJ, Hug LA, Zarek M, Zila A, Edwards EA
2012, Applied and environmental microbiology, 78, 5280-7, 22635995
Genomic determinants of organohalide-respiration in Geobacter lovleyi, an unusual member of the Geobacteraceae
Wagner DD, Hug LA, Hatt JK, Spitzmiller MR, Padilla-Crespo E, Ritalahti KM, Edwards EA, Konstantinidis KT, Löffler FE
2012, BMC genomics, 13, 200, 22616984
Dehalococcoides mccartyi gen. nov., sp. nov., obligately organohalide-respiring anaerobic bacteria relevant to halogen cycling and bioremediation, belong to a novel bacterial class, Dehalococcoidia classis nov., order Dehalococcoidales ord. nov. and family Dehalococcoidaceae fam. nov., within the phylum Chloroflexi
Löffler FE, Yan J, Ritalahti KM, Adrian L, Edwards EA, Konstantinidis KT, Müller JA, Fullerton H, Zinder SH, Spormann AM
2013, International journal of systematic and evolutionary microbiology, 63, 625-35, 22544797
Application of time-of-flight-secondary ion mass spectrometry for the detection of enzyme activity on solid wood substrates
Goacher RE, Edwards EA, Yakunin AF, Mims CA, Master ER
2012, Analytical chemistry, 84, 4443-51, 22507179
Monitoring biodegradation of ethene and bioremediation of chlorinated ethenes at a contaminated site using compound-specific isotope analysis (CSIA)
Mundle SO, Johnson T, Lacrampe-Couloume G, Pérez-de-Mora A, Duhamel M, Edwards EA, McMaster ML, Cox E, Révész K, Sherwood Lollar B
2012, Environmental science & technology, 46, 1731-8, 22201221
2011
Transcriptional analysis of a Dehalococcoides-containing microbial consortium reveals prophage activation
Waller AS, Hug LA, Mo K, Radford DR, Maxwell KL, Edwards EA
2012, Applied and environmental microbiology, 78, 1178-86, 22179237
Quantifying the effects of 1,1,1-trichloroethane and 1,1-dichloroethane on chlorinated ethene reductive dehalogenases
Chan WW, Grostern A, Löffler FE, Edwards EA
2011, Environmental science & technology, 45, 9693-702, 21955221
Pathway-dependent isotope fractionation during aerobic and anaerobic degradation of monochlorobenzene and 1,2,4-trichlorobenzene
Liang X, Howlett MR, Nelson JL, Grant G, Dworatzek S, Lacrampe-Couloume G, Zinder SH, Edwards EA, Sherwood Lollar B
2011, Environmental science & technology, 45, 8321-7, 21851082
Design and verification of a pangenome microarray oligonucleotide probe set for Dehalococcoides spp
Hug LA, Salehi M, Nuin P, Tillier ER, Edwards EA
2011, Applied and environmental microbiology, 77, 5361-9, 21666017
Site-specific mobilization of vinyl chloride respiration islands by a mechanism common in Dehalococcoides
McMurdie PJ, Hug LA, Edwards EA, Holmes S, Spormann AM
2011, BMC genomics, 12, 287, 21635780
Mapping the reaction coordinates of enzymatic defluorination
Chan PW, Yakunin AF, Edwards EA, Pai EF
2011, Journal of the American Chemical Society, 133, 7461-8, 21510690
2010
Insights into enzyme kinetics of chloroethane biodegradation using compound specific stable isotopes
Lollar BS, Hirschorn S, Mundle SO, Grostern A, Edwards EA, Lacrampe-Couloume G
2010, Environmental science & technology, 44, 7498-503, 20831217
Characterizing the metabolism of Dehalococcoides with a constraint-based model
Ahsanul Islam M, Edwards EA, Mahadevan R
2010, PLoS computational biology, 6, 20811585
Do New Zealand children with non-cystic fibrosis bronchiectasis show disease progression?
Munro KA, Reed PW, Joyce H, Perry D, Twiss J, Byrnes CA, Edwards EA
2011, Pediatric pulmonology, 46, 131-8, 20717910
Chloroform respiration to dichloromethane by a Dehalobacter population
Grostern A, Duhamel M, Dworatzek S, Edwards EA
2010, Environmental microbiology, 12, 1053-60, 20089043
Resolution of sleep-disordered breathing in a dialysis-dependent child post-renal transplantation
Ball E, Kara T, McNamara D, Edwards EA
2010, Pediatric nephrology (Berlin, Germany), 25, 173-7, 19680696
2009
Sequence- and activity-based screening of microbial genomes for novel dehalogenases
Chan WY, Wong M, Guthrie J, Savchenko AV, Yakunin AF, Pai EF, Edwards EA
2010, Microbial biotechnology, 3, 107-20, 21255311
Planktonic cell yield is linked to biofilm development
Bester E, Edwards EA, Wolfaardt GM
2009, Canadian journal of microbiology, 55, 1195-206, 19935892
1,1,1-trichloroethane and 1,1-dichloroethane reductive dechlorination kinetics and co-contaminant effects in a Dehalobacter-containing mixed culture
Grostern A, Chan WW, Edwards EA
2009, Environmental science & technology, 43, 6799-807, 19764252
Characterization of a Dehalobacter coculture that dechlorinates 1,2-dichloroethane to ethene and identification of the putative reductive dehalogenase gene
Grostern A, Edwards EA
2009, Applied and environmental microbiology, 75, 2684-93, 19270140
2008
Isotopic evidence suggests different initial reaction mechanisms for anaerobic benzene biodegradation
Mancini SA, Devine CE, Elsner M, Nandi ME, Ulrich AC, Edwards EA, Lollar BS
2008, Environmental science & technology, 42, 8290-6, 19068808
Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities
Skidmore MA, Dumax-Vorzet AF, Guimond SE, Rudd TR, Edwards EA, Turnbull JE, Craig AG, Yates EA
2008, Journal of medicinal chemistry, 51, 1453-8, 18260612
2007
A future for the protein structure initiative
Edwards AM, Edwards EA
2007, Structure (London, England : 1993), 15, 1525-6, 18073101
Quantification of biotransformation of chlorinated hydrocarbons in a biostimulation study: added value via stable carbon isotope analysis
Hirschorn SK, Grostern A, Lacrampe-Couloume G, Edwards EA, Mackinnon L, Repta C, Major DW, Sherwood Lollar B
2007, Journal of contaminant hydrology, 94, 249-60, 17689820
Isotope analysis as a natural reaction probe to determine mechanisms of biodegradation of 1,2-dichloroethane
Hirschorn SK, Dinglasan-Panlilio MJ, Edwards EA, Lacrampe-Couloume G, Sherwood Lollar B
2007, Environmental microbiology, 9, 1651-7, 17564600
Sleep studies frequently lead to changes in respiratory support in children
Tan E, Nixon GM, Edwards EA
2007, Journal of paediatrics and child health, 43, 560-3, 17635687
Growth and yields of dechlorinators, acetogens, and methanogens during reductive dechlorination of chlorinated ethenes and dihaloelimination of 1 ,2-dichloroethane
Duhamel M, Edwards EA
2007, Environmental science & technology, 41, 2303-10, 17438779
2006
Effects of trace element concentration on enzyme controlled stable isotope fractionation during aerobic biodegradation of toluene
Mancini SA, Hirschorn SK, Elsner M, Lacrampe-Couloume G, Sleep BE, Edwards EA, Lollar BS
2006, Environmental science & technology, 40, 7675-81, 17256512
Identification and expression of benzylsuccinate synthase genes in a toluene-degrading methanogenic consortium
Washer CE, Edwards EA
2007, Applied and environmental microbiology, 73, 1367-9, 17142355
Microbial composition of chlorinated ethene-degrading cultures dominated by Dehalococcoides
Duhamel M, Edwards EA
2006, FEMS microbiology ecology, 58, 538-49, 17117995
A 1,1,1-trichloroethane-degrading anaerobic mixed microbial culture enhances biotransformation of mixtures of chlorinated ethenes and ethanes
Grostern A, Edwards EA
2006, Applied and environmental microbiology, 72, 7849-56, 17056695
Heparin derivatives as inhibitors of BACE-1, the Alzheimer’s beta-secretase, with reduced activity against factor Xa and other proteases
Patey SJ, Edwards EA, Yates EA, Turnbull JE
2006, Journal of medicinal chemistry, 49, 6129-32, 17004727
Evaluation of isotopic enrichment factors for the biodegradation of chlorinated ethenes using a parameter estimation model: toward an improved quantification of biodegradation
Morrill PL, Sleep BE, Slater GF, Edwards EA, Lollar BS
2006, Environmental science & technology, 40, 3886-92, 16830557
Biological enhancement of tetrachloroethene dissolution and associated microbial community changes
Sleep BE, Seepersad DJ, Kaiguo MO, Heidorn CM, Hrapovic L, Morrill PL, McMaster ML, Hood ED, Lebron C, Lollar BS, Major DW, Edwards EA
2006, Environmental science & technology, 40, 3623-33, 16786703
Harnessing microbial activities for environmental cleanup
Löffler FE, Edwards EA
2006, Current opinion in biotechnology, 17, 274-84, 16697178
Growth of Dehalobacter and Dehalococcoides spp. during degradation of chlorinated ethanes
Grostern A, Edwards EA
2006, Applied and environmental microbiology, 72, 428-36, 16391074
2005
Multiple reductive-dehalogenase-homologous genes are simultaneously transcribed during dechlorination by Dehalococcoides-containing cultures
Waller AS, Krajmalnik-Brown R, Löffler FE, Edwards EA
2005, Applied and environmental microbiology, 71, 8257-64, 16332811
Metabolites detected during biodegradation of 13C6-benzene in nitrate-reducing and methanogenic enrichment cultures
Ulrich AC, Beller HR, Edwards EA
2005, Environmental science & technology, 39, 6681-91, 16190227
Carbon isotopic fractionation during aerobic vinyl chloride degradation
Chartrand MM, Waller A, Mattes TE, Elsner M, Lacrampe-Couloume G, Gossett JM, Edwards EA, Lollar BS
2005, Environmental science & technology, 39, 1064-70, 15773478
Quantifying chlorinated ethene degradation during reductive dechlorination at Kelly AFB using stable carbon isotopes
Morrill PL, Lacrampe-Couloume G, Slater GF, Sleep BE, Edwards EA, McMaster ML, Major DW, Sherwood Lollar B
2005, Journal of contaminant hydrology, 76, 279-93, 15683884
2004
Gene expression profiles for detecting and distinguishing potential endocrine-disrupting compounds in environmental samples
Wang DY, McKague B, Liss SN, Edwards EA
2004, Environmental science & technology, 38, 6396-406, 15597897
Pathway dependent isotopic fractionation during aerobic biodegradation of 1,2-dichloroethane
Hirschorn SK, Dinglasan MJ, Elsner M, Mancini SA, Lacrampe-Couloume G, Edwards EA, Lollar BS
2004, Environmental science & technology, 38, 4775-81, 15487787
Characterization of a highly enriched dehalococcoides-containing culture that grows on vinyl chloride and trichloroethene
Duhamel M, Mo K, Edwards EA
2004, Applied and environmental microbiology, 70, 5538-45, 15345442
Treatment of paediatric non-cystic fibrosis bronchiectasis
Edwards EA, Twiss J, Byrnes CA
2004, Expert opinion on pharmacotherapy, 5, 1471-84, 15212598
Fluorotelomer alcohol biodegradation yields poly- and perfluorinated acids
Dinglasan MJ, Ye Y, Edwards EA, Mabury SA
2004, Environmental science & technology, 38, 2857-64, 15212260
Perchlorate-reducing microorganisms isolated from contaminated sites
Waller AS, Cox EE, Edwards EA
2004, Environmental microbiology, 6, 517-27, 15049925
2003
DNA microarrays for detecting endocrine-disrupting compounds
Francois E, Wang DY, Fulthorpe R, Liss SN, Edwards EA
2003, Biotechnology advances, 22, 17-26, 14623040
Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1
Wang DY, Fulthorpe R, Liss SN, Edwards EA
2004, Molecular endocrinology (Baltimore, Md.), 18, 402-11, 14605097
Physiological and molecular characterization of anaerobic benzene-degrading mixed cultures
Ulrich AC, Edwards EA
2003, Environmental microbiology, 5, 92-102, 12558592
Monitoring gene expression in mixed microbial communities by using DNA microarrays
Dennis P, Edwards EA, Liss SN, Fulthorpe R
2003, Applied and environmental microbiology, 69, 769-78, 12570994
Carbon and hydrogen isotopic fractionation during anaerobic biodegradation of benzene
Mancini SA, Ulrich AC, Lacrampe-Couloume G, Sleep B, Edwards EA, Lollar BS
2003, Applied and environmental microbiology, 69, 191-8, 12513995
2002
Field demonstration of successful bioaugmentation to achieve dechlorination of tetrachloroethene to ethene
Major DW, McMaster ML, Cox EE, Edwards EA, Dworatzek SM, Hendrickson ER, Starr MG, Payne JA, Buonamici LW
2002, Environmental science & technology, 36, 5106-16, 12523427