Professor Elizabeth Edwards

Elizabeth A. Edwards



St. George (downtown)

CSB Appointment


Research Areas

Bioinformatics / Computational Biology, Biotechnology, Genetics / Genomics, Metabolomics, Microbiology, Proteomics


Ph.D. Stanford 1993
M. Eng. McGill 1985
B. Eng. McGill 1983

Titles and Honors

Canada Research Chair (tier 1) in Anaerobic Biotechnology, 2014
Fellow, Royal Society of Canada, 2012
Fellow, Canadian Academy of Engineering 2011
Fellow, AAAS, 2011
Killam Research Fellowship, 2008-2010

Primary Undergraduate Department

Chemical Engineering & Applied Chemistry

Graduate Programs

Cell & Systems Biology
Genome Biology & Bioinformatics

Academic or Administrative Appointments

Director, BioZone Centre for Applied Bioscience and Bioengineering Research

Research Description

Contact Information

Office Phone: 416-946-3506
Office: WB420D
Lab: WB311
Lab Phone: 416-978-4222

Mailing Address

Department of Chemical Engineering & Applied Chemistry
University of Toronto
200 College St.
Toronto, ON M5S 3E5

Visit lab’s website



Bioremediation of chlorinated ethenes in fractured bedrock and associated changes in dechlorinating and nondechlorinating microbial populations

Pérez-de-Mora A, Zila A, McMaster ML, Edwards EA
2014, Environmental science & technology, 48, 5770-9, 24724903

Metatranscriptome of an anaerobic benzene-degrading, nitrate-reducing enrichment culture reveals involvement of carboxylation in benzene ring activation

Luo F, Gitiafroz R, Devine CE, Gong Y, Hug LA, Raskin L, Edwards EA
2014, Applied and environmental microbiology, 80, 4095-107, 24795366

New insights into Dehalococcoides mccartyi metabolism from a reconstructed metabolic network-based systems-level analysis of D. mccartyi transcriptomes

Islam MA, Waller AS, Hug LA, Provart NJ, Edwards EA, Mahadevan R
2014, PloS one, 9, e94808, 24733489

Bioaugmentation with distinct Dehalobacter strains achieves chloroform detoxification in microcosms

Justicia-Leon SD, Higgins S, Mack EE, Griffiths DR, Tang S, Edwards EA, Löffler FE
2014, Environmental science & technology, 48, 1851-8, 24392834

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Complete Genome Sequence of Bacteroidales Strain CF from a Chloroform-Dechlorinating Enrichment Culture

Tang S, Edwards EA
2013, Genome announcements, 1, 24356833

Diversity of reductive dehalogenase genes from environmental samples and enrichment cultures identified with degenerate primer PCR screens

Hug LA, Edwards EA
2013, Frontiers in microbiology, 4, 341, 24312087

Meeting report: 1st international functional metagenomics workshop may 7-8, 2012, st. Jacobs, ontario, Canada

Engel K, Ashby D, Brady SF, Cowan DA, Doemer J, Edwards EA, Fiebig K, Martens EC, McCormac D, Mead DA, Miyazaki K, Moreno-Hagelsieb G, O'Gara F, Reid A, Rose DR, Simonet P, Sjöling S, Smalla K, Streit WR, Tedman-Jones J, Valla S, Wellington EM, Wu CC, Liles MR, Neufeld JD, Sessitsch A, Charles TC
2013, Standards in genomic sciences, 8, 106-11, 23961315

Overview of organohalide-respiring bacteria and a proposal for a classification system for reductive dehalogenases

Hug LA, Maphosa F, Leys D, Löffler FE, Smidt H, Edwards EA, Adrian L
2013, Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368, 20120322, 23479752

Identification of Dehalobacter reductive dehalogenases that catalyse dechlorination of chloroform, 1,1,1-trichloroethane and 1,1-dichloroethane

Tang S, Edwards EA
2013, Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368, 20120318, 23479748

Anaerobic conversion of chlorobenzene and benzene to CH4 and CO2 in bioaugmented microcosms

Liang X, Devine CE, Nelson J, Sherwood Lollar B, Zinder S, Edwards EA
2013, Environmental science & technology, 47, 2378-85, 23360185

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Semi-automatic in silico gap closure enabled de novo assembly of two Dehalobacter genomes from metagenomic data

Tang S, Gong Y, Edwards EA
2012, PloS one, 7, e52038, 23284863

Paediatric home ventilatory support: changing milieu, proactive solutions

Edwards EA, Nixon GM,
2013, Journal of paediatrics and child health, 49, 13-8, 23252372

Functional characterization of reductive dehalogenases by using blue native polyacrylamide gel electrophoresis

Tang S, Chan WW, Fletcher KE, Seifert J, Liang X, Löffler FE, Edwards EA, Adrian L
2013, Applied and environmental microbiology, 79, 974-81, 23204411

Large carbon isotope fractionation during biodegradation of chloroform by Dehalobacter cultures

Chan CC, Mundle SO, Eckert T, Liang X, Tang S, Lacrampe-Couloume G, Edwards EA, Lollar BS
2012, Environmental science & technology, 46, 10154-60, 22900494

Comparative metagenomics of three Dehalococcoides-containing enrichment cultures: the role of the non-dechlorinating community

Hug LA, Beiko RG, Rowe AR, Richardson RE, Edwards EA
2012, BMC genomics, 13, 327, 22823523

Discovery of a trans-dichloroethene-respiring Dehalogenimonas species in the 1,1,2,2-tetrachloroethane-dechlorinating WBC-2 consortium

Manchester MJ, Hug LA, Zarek M, Zila A, Edwards EA
2012, Applied and environmental microbiology, 78, 5280-7, 22635995

Genomic determinants of organohalide-respiration in Geobacter lovleyi, an unusual member of the Geobacteraceae

Wagner DD, Hug LA, Hatt JK, Spitzmiller MR, Padilla-Crespo E, Ritalahti KM, Edwards EA, Konstantinidis KT, Löffler FE
2012, BMC genomics, 13, 200, 22616984

Dehalococcoides mccartyi gen. nov., sp. nov., obligately organohalide-respiring anaerobic bacteria relevant to halogen cycling and bioremediation, belong to a novel bacterial class, Dehalococcoidia classis nov., order Dehalococcoidales ord. nov. and family Dehalococcoidaceae fam. nov., within the phylum Chloroflexi

Löffler FE, Yan J, Ritalahti KM, Adrian L, Edwards EA, Konstantinidis KT, Müller JA, Fullerton H, Zinder SH, Spormann AM
2013, International journal of systematic and evolutionary microbiology, 63, 625-35, 22544797

Application of time-of-flight-secondary ion mass spectrometry for the detection of enzyme activity on solid wood substrates

Goacher RE, Edwards EA, Yakunin AF, Mims CA, Master ER
2012, Analytical chemistry, 84, 4443-51, 22507179

Monitoring biodegradation of ethene and bioremediation of chlorinated ethenes at a contaminated site using compound-specific isotope analysis (CSIA)

Mundle SO, Johnson T, Lacrampe-Couloume G, Pérez-de-Mora A, Duhamel M, Edwards EA, McMaster ML, Cox E, Révész K, Sherwood Lollar B
2012, Environmental science & technology, 46, 1731-8, 22201221

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Transcriptional analysis of a Dehalococcoides-containing microbial consortium reveals prophage activation

Waller AS, Hug LA, Mo K, Radford DR, Maxwell KL, Edwards EA
2012, Applied and environmental microbiology, 78, 1178-86, 22179237

Quantifying the effects of 1,1,1-trichloroethane and 1,1-dichloroethane on chlorinated ethene reductive dehalogenases

Chan WW, Grostern A, Löffler FE, Edwards EA
2011, Environmental science & technology, 45, 9693-702, 21955221

Pathway-dependent isotope fractionation during aerobic and anaerobic degradation of monochlorobenzene and 1,2,4-trichlorobenzene

Liang X, Howlett MR, Nelson JL, Grant G, Dworatzek S, Lacrampe-Couloume G, Zinder SH, Edwards EA, Sherwood Lollar B
2011, Environmental science & technology, 45, 8321-7, 21851082

Design and verification of a pangenome microarray oligonucleotide probe set for Dehalococcoides spp

Hug LA, Salehi M, Nuin P, Tillier ER, Edwards EA
2011, Applied and environmental microbiology, 77, 5361-9, 21666017

Site-specific mobilization of vinyl chloride respiration islands by a mechanism common in Dehalococcoides

McMurdie PJ, Hug LA, Edwards EA, Holmes S, Spormann AM
2011, BMC genomics, 12, 287, 21635780

Mapping the reaction coordinates of enzymatic defluorination

Chan PW, Yakunin AF, Edwards EA, Pai EF
2011, Journal of the American Chemical Society, 133, 7461-8, 21510690

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Insights into enzyme kinetics of chloroethane biodegradation using compound specific stable isotopes

Lollar BS, Hirschorn S, Mundle SO, Grostern A, Edwards EA, Lacrampe-Couloume G
2010, Environmental science & technology, 44, 7498-503, 20831217

Characterizing the metabolism of Dehalococcoides with a constraint-based model

Ahsanul Islam M, Edwards EA, Mahadevan R
2010, PLoS computational biology, 6, 20811585

Do New Zealand children with non-cystic fibrosis bronchiectasis show disease progression?

Munro KA, Reed PW, Joyce H, Perry D, Twiss J, Byrnes CA, Edwards EA
2011, Pediatric pulmonology, 46, 131-8, 20717910

Chloroform respiration to dichloromethane by a Dehalobacter population

Grostern A, Duhamel M, Dworatzek S, Edwards EA
2010, Environmental microbiology, 12, 1053-60, 20089043

Resolution of sleep-disordered breathing in a dialysis-dependent child post-renal transplantation

Ball E, Kara T, McNamara D, Edwards EA
2010, Pediatric nephrology (Berlin, Germany), 25, 173-7, 19680696

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Sequence- and activity-based screening of microbial genomes for novel dehalogenases

Chan WY, Wong M, Guthrie J, Savchenko AV, Yakunin AF, Pai EF, Edwards EA
2010, Microbial biotechnology, 3, 107-20, 21255311

Planktonic cell yield is linked to biofilm development

Bester E, Edwards EA, Wolfaardt GM
2009, Canadian journal of microbiology, 55, 1195-206, 19935892

1,1,1-trichloroethane and 1,1-dichloroethane reductive dechlorination kinetics and co-contaminant effects in a Dehalobacter-containing mixed culture

Grostern A, Chan WW, Edwards EA
2009, Environmental science & technology, 43, 6799-807, 19764252

Characterization of a Dehalobacter coculture that dechlorinates 1,2-dichloroethane to ethene and identification of the putative reductive dehalogenase gene

Grostern A, Edwards EA
2009, Applied and environmental microbiology, 75, 2684-93, 19270140

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Isotopic evidence suggests different initial reaction mechanisms for anaerobic benzene biodegradation

Mancini SA, Devine CE, Elsner M, Nandi ME, Ulrich AC, Edwards EA, Lollar BS
2008, Environmental science & technology, 42, 8290-6, 19068808

Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities

Skidmore MA, Dumax-Vorzet AF, Guimond SE, Rudd TR, Edwards EA, Turnbull JE, Craig AG, Yates EA
2008, Journal of medicinal chemistry, 51, 1453-8, 18260612

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A future for the protein structure initiative

Edwards AM, Edwards EA
2007, Structure (London, England : 1993), 15, 1525-6, 18073101

Quantification of biotransformation of chlorinated hydrocarbons in a biostimulation study: added value via stable carbon isotope analysis

Hirschorn SK, Grostern A, Lacrampe-Couloume G, Edwards EA, Mackinnon L, Repta C, Major DW, Sherwood Lollar B
2007, Journal of contaminant hydrology, 94, 249-60, 17689820

Isotope analysis as a natural reaction probe to determine mechanisms of biodegradation of 1,2-dichloroethane

Hirschorn SK, Dinglasan-Panlilio MJ, Edwards EA, Lacrampe-Couloume G, Sherwood Lollar B
2007, Environmental microbiology, 9, 1651-7, 17564600

Sleep studies frequently lead to changes in respiratory support in children

Tan E, Nixon GM, Edwards EA
2007, Journal of paediatrics and child health, 43, 560-3, 17635687

Growth and yields of dechlorinators, acetogens, and methanogens during reductive dechlorination of chlorinated ethenes and dihaloelimination of 1 ,2-dichloroethane

Duhamel M, Edwards EA
2007, Environmental science & technology, 41, 2303-10, 17438779

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Effects of trace element concentration on enzyme controlled stable isotope fractionation during aerobic biodegradation of toluene

Mancini SA, Hirschorn SK, Elsner M, Lacrampe-Couloume G, Sleep BE, Edwards EA, Lollar BS
2006, Environmental science & technology, 40, 7675-81, 17256512

Identification and expression of benzylsuccinate synthase genes in a toluene-degrading methanogenic consortium

Washer CE, Edwards EA
2007, Applied and environmental microbiology, 73, 1367-9, 17142355

Microbial composition of chlorinated ethene-degrading cultures dominated by Dehalococcoides

Duhamel M, Edwards EA
2006, FEMS microbiology ecology, 58, 538-49, 17117995

A 1,1,1-trichloroethane-degrading anaerobic mixed microbial culture enhances biotransformation of mixtures of chlorinated ethenes and ethanes

Grostern A, Edwards EA
2006, Applied and environmental microbiology, 72, 7849-56, 17056695

Heparin derivatives as inhibitors of BACE-1, the Alzheimer’s beta-secretase, with reduced activity against factor Xa and other proteases

Patey SJ, Edwards EA, Yates EA, Turnbull JE
2006, Journal of medicinal chemistry, 49, 6129-32, 17004727

Evaluation of isotopic enrichment factors for the biodegradation of chlorinated ethenes using a parameter estimation model: toward an improved quantification of biodegradation

Morrill PL, Sleep BE, Slater GF, Edwards EA, Lollar BS
2006, Environmental science & technology, 40, 3886-92, 16830557

Biological enhancement of tetrachloroethene dissolution and associated microbial community changes

Sleep BE, Seepersad DJ, Kaiguo MO, Heidorn CM, Hrapovic L, Morrill PL, McMaster ML, Hood ED, Lebron C, Lollar BS, Major DW, Edwards EA
2006, Environmental science & technology, 40, 3623-33, 16786703

Harnessing microbial activities for environmental cleanup

Löffler FE, Edwards EA
2006, Current opinion in biotechnology, 17, 274-84, 16697178

Growth of Dehalobacter and Dehalococcoides spp. during degradation of chlorinated ethanes

Grostern A, Edwards EA
2006, Applied and environmental microbiology, 72, 428-36, 16391074

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Multiple reductive-dehalogenase-homologous genes are simultaneously transcribed during dechlorination by Dehalococcoides-containing cultures

Waller AS, Krajmalnik-Brown R, Löffler FE, Edwards EA
2005, Applied and environmental microbiology, 71, 8257-64, 16332811

Metabolites detected during biodegradation of 13C6-benzene in nitrate-reducing and methanogenic enrichment cultures

Ulrich AC, Beller HR, Edwards EA
2005, Environmental science & technology, 39, 6681-91, 16190227

Carbon isotopic fractionation during aerobic vinyl chloride degradation

Chartrand MM, Waller A, Mattes TE, Elsner M, Lacrampe-Couloume G, Gossett JM, Edwards EA, Lollar BS
2005, Environmental science & technology, 39, 1064-70, 15773478

Quantifying chlorinated ethene degradation during reductive dechlorination at Kelly AFB using stable carbon isotopes

Morrill PL, Lacrampe-Couloume G, Slater GF, Sleep BE, Edwards EA, McMaster ML, Major DW, Sherwood Lollar B
2005, Journal of contaminant hydrology, 76, 279-93, 15683884

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Gene expression profiles for detecting and distinguishing potential endocrine-disrupting compounds in environmental samples

Wang DY, McKague B, Liss SN, Edwards EA
2004, Environmental science & technology, 38, 6396-406, 15597897

Pathway dependent isotopic fractionation during aerobic biodegradation of 1,2-dichloroethane

Hirschorn SK, Dinglasan MJ, Elsner M, Mancini SA, Lacrampe-Couloume G, Edwards EA, Lollar BS
2004, Environmental science & technology, 38, 4775-81, 15487787

Characterization of a highly enriched dehalococcoides-containing culture that grows on vinyl chloride and trichloroethene

Duhamel M, Mo K, Edwards EA
2004, Applied and environmental microbiology, 70, 5538-45, 15345442

Treatment of paediatric non-cystic fibrosis bronchiectasis

Edwards EA, Twiss J, Byrnes CA
2004, Expert opinion on pharmacotherapy, 5, 1471-84, 15212598

Fluorotelomer alcohol biodegradation yields poly- and perfluorinated acids

Dinglasan MJ, Ye Y, Edwards EA, Mabury SA
2004, Environmental science & technology, 38, 2857-64, 15212260

Perchlorate-reducing microorganisms isolated from contaminated sites

Waller AS, Cox EE, Edwards EA
2004, Environmental microbiology, 6, 517-27, 15049925

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DNA microarrays for detecting endocrine-disrupting compounds

Francois E, Wang DY, Fulthorpe R, Liss SN, Edwards EA
2003, Biotechnology advances, 22, 17-26, 14623040

Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1

Wang DY, Fulthorpe R, Liss SN, Edwards EA
2004, Molecular endocrinology (Baltimore, Md.), 18, 402-11, 14605097

Physiological and molecular characterization of anaerobic benzene-degrading mixed cultures

Ulrich AC, Edwards EA
2003, Environmental microbiology, 5, 92-102, 12558592

Monitoring gene expression in mixed microbial communities by using DNA microarrays

Dennis P, Edwards EA, Liss SN, Fulthorpe R
2003, Applied and environmental microbiology, 69, 769-78, 12570994

Carbon and hydrogen isotopic fractionation during anaerobic biodegradation of benzene

Mancini SA, Ulrich AC, Lacrampe-Couloume G, Sleep B, Edwards EA, Lollar BS
2003, Applied and environmental microbiology, 69, 191-8, 12513995

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Field demonstration of successful bioaugmentation to achieve dechlorination of tetrachloroethene to ethene

Major DW, McMaster ML, Cox EE, Edwards EA, Dworatzek SM, Hendrickson ER, Starr MG, Payne JA, Buonamici LW
2002, Environmental science & technology, 36, 5106-16, 12523427

Comparison of anaerobic dechlorinating enrichment cultures maintained on tetrachloroethene, trichloroethene, cis-dichloroethene and vinyl chloride

Duhamel M, Wehr SD, Yu L, Rizvi H, Seepersad D, Dworatzek S, Cox EE, Edwards EA
2002, Water research, 36, 4193-202, 12420924

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