Professor Mary Cheng

Hai-Ying (Mary) Cheng




CSB Appointment


Research Areas

Animal Biology, Neurobiology, Physiology

Titles and Honors

Canada Research Chair in Molecular Genetics of Biological Clocks

Primary Undergraduate Department

Biology, UTM

Graduate Programs

Cell & Systems Biology

Research Description

Circadian clock mechanisms in mammals; genetic determinants of adult neurogenesis.

Contact Information

Office Phone: 905-569-4299
Office: DV3044
Lab: DV A4021
Lab Phone: 905-569-5689

Mailing Address

Department of Biology
University of Toronto
3359 Mississauga Road
Mississauga, ON L5L 1C6

Visit lab’s website

Recent News

Congratulations to CSB’s Graduate Student Award Recipients!

Congratulations to our Graduate Students who earned recognition for their accomplishments at our Graduate Student Awards on December 19th, 2022!…

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Revealing a role of microRNAs in the regulation of the biological clock

Cheng HY, Obrietan K
2007, Cell cycle (Georgetown, Tex.), 6, 3034-5, 18075311

microRNA modulation of circadian-clock period and entrainment

Cheng HY, Papp JW, Varlamova O, Dziema H, Russell B, Curfman JP, Nakazawa T, Shimizu K, Okamura H, Impey S, Obrietan K
2007, Neuron, 54, 813-29, 17553428

Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousal

Huang H, Acuna-Goycolea C, Li Y, Cheng HM, Obrietan K, van den Pol AN
2007, The Journal of neuroscience : the official journal of the Society for Neuroscience, 27, 4870-81, 17475795

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The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock

Cheng HY, Dziema H, Papp J, Mathur DP, Koletar M, Ralph MR, Penninger JM, Obrietan K
2006, The Journal of neuroscience : the official journal of the Society for Neuroscience, 26, 12984-95, 17167088

Dexras1: shaping the responsiveness of the circadian clock

Cheng HY, Obrietan K
2006, Seminars in cell & developmental biology, 17, 345-51, 16765612

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Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism

Butcher GQ, Lee B, Cheng HY, Obrietan K
2005, The Journal of neuroscience : the official journal of the Society for Neuroscience, 25, 5305-13, 15930378

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Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock

Cheng HY, Obrietan K, Cain SW, Lee BY, Agostino PV, Joza NA, Harrington ME, Ralph MR, Penninger JM
2004, Neuron, 43, 715-28, 15339652

DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine

Cheng HY, Laviolette SR, van der Kooy D, Penninger JM
2004, The European journal of neuroscience, 19, 3033-41, 15182311

MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence

Wada T, Joza N, Cheng HY, Sasaki T, Kozieradzki I, Bachmaier K, Katada T, Schreiber M, Wagner EF, Nishina H, Penninger JM
2004, Nature cell biology, 6, 215-26, 15039780

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Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, Oliveira-dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann MP, Backx PH, Penninger JM
2002, Cell, 110, 737-49, 12297047

DREAM is a critical transcriptional repressor for pain modulation

Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, Sarosi I, Woodgett JR, Oliveira-dos-Santos AJ, Ikura M, van der Kooy D, Salter MW, Penninger JM
2002, Cell, 108, 31-43, 11792319

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Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3

Osawa M, Tong KI, Lilliehook C, Wasco W, Buxbaum JD, Cheng HY, Penninger JM, Ikura M, Ames JB
2001, The Journal of biological chemistry, 276, 41005-13, 11535596

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zúñiga-Pflücker JC, Kroemer G, Penninger JM
2001, Nature, 410, 549-54, 11279485

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, Griffiths E, Krawczyk C, Richardson CD, Aitken K, Iscove N, Koretzky G, Johnson P, Liu P, Rothstein DM, Penninger JM
2001, Nature, 409, 349-54, 11201744

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