Iva Zovkic
Assistant Professor
Campus
UTM
CSB Appointment
Full
Research Areas
Neurobiology
Education
B.A. (Psychology: Brock University)
Ph.D. (Psychology: Behavioural Neuroscience, Brock University)
Postdoctoral fellowship (Neurobiology: University of Alabama at Birmingham)
Primary Undergraduate Department
Psychology
Graduate Programs
Cell & Systems Biology
Biology and Behaviour, Psychology
Research Description
Epigenetic mechanisms of learning and memory in rodents; role of histone variants in memory formation and maintenance; age-related cognitive decline.
Contact Information
Office Phone: 905-828-3961
Office: CC4071
Email
Mailing Address
University of Toronto Mississauga
CCT Building, Rm 4071
3359 Mississauga Road
Mississauga, Ontario L5L 1C6
Recent News
Publications
2022
Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice
Singh G, Stefanelli G, Narkaj K, Brimble MA, Creighton SD, McLean TAB, Hall M, Mitchnick KA, Zakaria J, Phung T, Reda A, Leonetti AM, Monks A, Ianov L, Winters BD, Walters BJ, Davidoff AM, Mitchell JA, Zovkic IB
2022, Communications Biology, 10.1038/s42003-022-03435-4
2016
Advanced In vivo Use of CRISPR/Cas9 and Anti-sense DNA Inhibition for Gene Manipulation in the Brain
Walters BJ, Azam AB, Gillon CJ, Josselyn SA, Zovkic IB
2015, Frontiers in genetics, 6, 362, 26793235
2015
H2A.Z helps genes remember their history so we can remember ours
Zovkic IB, Walters BJ
2015, BioEssays : news and reviews in molecular, cellular and developmental biology, 25880368
Memory-Associated Dynamic Regulation of the “Stable” Core of the Chromatin Particle
Zovkic IB, Sweatt JD
2015, Neuron, 87, 1-4, 26139363
Building up and knocking down: An emerging role for epigenetics and proteasomal degradation in systems consolidation
Walters BJ, Zovkic IB
2015, Neuroscience, 300, 39-52, 25967264
2014
Histone H2A.Z subunit exchange controls consolidation of recent and remote memory
Zovkic IB, Paulukaitis BS, Day JJ, Etikala DM, Sweatt JD
2014, Nature, 515, 582-6, 25219850
2013
Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD
Zovkic IB, Meadows JP, Kaas GA, Sweatt JD
2013, Frontiers in psychiatry, 4, 60, 23805109
Epigenetic regulation of memory formation and maintenance
Zovkic IB, Guzman-Karlsson MC, Sweatt JD
2013, Learning & memory (Cold Spring Harbor, N.Y.), 20, 61-74, 23322554
2012
Role of medial prefrontal cortex dopamine in age differences in response to amphetamine in rats: locomotor activity after intra-mPFC injections of dopaminergic ligands
Mathews IZ, McCormick CM
2012, Developmental neurobiology, 72, 1415-21, 22081646
Epigenetic mechanisms in learned fear: implications for PTSD
Zovkic IB, Sweatt JD
2013, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38, 77-93, 22692566
2011
Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood
McCormick CM, Thomas CM, Sheridan CS, Nixon F, Flynn JA, Mathews IZ
2012, Hippocampus, 22, 1300-12, 21805526
Heightened locomotor-activating effects of amphetamine administered into the nucleus accumbens in adolescent rats
Mathews IZ, Brudzynski SM, McCormick CM
2011, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 29, 501-7, 21616135
2010
Low doses of amphetamine lead to immediate and lasting locomotor sensitization in adolescent, not adult, male rats
Mathews IZ, Kelly H, McCormick CM
2011, Pharmacology, biochemistry, and behavior, 97, 640-6, 21108958
Enduring deficits in contextual and auditory fear conditioning after adolescent, not adult, social instability stress in male rats
Morrissey MD, Mathews IZ, McCormick CM
2011, Neurobiology of learning and memory, 95, 46-56, 20970512
2009
Individual differences in activity predict locomotor activity and conditioned place preference to amphetamine in both adolescent and adult rats
Mathews IZ, Morrissey MD, McCormick CM
2010, Pharmacology, biochemistry, and behavior, 95, 63-71, 20006968
Adolescent development, hypothalamic-pituitary-adrenal function, and programming of adult learning and memory
McCormick CM, Mathews IZ
2010, Progress in neuro-psychopharmacology & biological psychiatry, 34, 756-65, 19782715
Investigations of HPA function and the enduring consequences of stressors in adolescence in animal models
McCormick CM, Mathews IZ, Thomas C, Waters P
2010, Brain and cognition, 72, 73-85, 19616355
Changes in hyporesponsiveness to acute amphetamine and age differences in tyrosine hydroxylase immunoreactivity in the brain over adolescence in male and female rats
Mathews IZ, Waters P, McCormick CM
2009, Developmental psychobiology, 51, 417-28, 19492363
2008
Chronic social stress in adolescence influenced both amphetamine conditioned place preference and locomotor sensitization
Mathews IZ, Mills RG, McCormick CM
2008, Developmental psychobiology, 50, 451-9, 18551462
Increased depressive behaviour in females and heightened corticosterone release in males to swim stress after adolescent social stress in rats
Mathews IZ, Wilton A, Styles A, McCormick CM
2008, Behavioural brain research, 190, 33-40, 18342957
2007
Female and male rats in late adolescence differ from adults in amphetamine-induced locomotor activity, but not in conditioned place preference for amphetamine
Mathews IZ, McCormick CM
2007, Behavioural pharmacology, 18, 641-50, 17912048
Effects of chronic social stress in adolescence on anxiety and neuroendocrine response to mild stress in male and female rats
McCormick CM, Smith C, Mathews IZ
2008, Behavioural brain research, 187, 228-38, 17945360