Professor Iva Zovkic

Iva Zovkic

Assistant Professor



CSB Appointment


Research Areas



B.A. (Psychology: Brock University)
Ph.D. (Psychology: Behavioural Neuroscience, Brock University)
Postdoctoral fellowship (Neurobiology: University of Alabama at Birmingham)

Primary Undergraduate Department


Graduate Programs

Cell & Systems Biology
Biology and Behaviour, Psychology

Research Description

Epigenetic mechanisms of learning and memory in rodents; role of histone variants in memory formation and maintenance; age-related cognitive decline.

Contact Information

Office Phone: 905-828-3961
Office: CC4071

Mailing Address

University of Toronto Mississauga
CCT Building, Rm 4071
3359 Mississauga Road
Mississauga, Ontario L5L 1C6

Visit lab’s website

Recent News

Congratulations to CSB’s Graduate Student Award Recipients!

Congratulations to our Graduate Students who earned recognition for their accomplishments at our Graduate Student Awards on December 19th, 2022!…

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Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice

Singh G, Stefanelli G, Narkaj K, Brimble MA, Creighton SD, McLean TAB, Hall M, Mitchnick KA, Zakaria J, Phung T, Reda A, Leonetti AM, Monks A, Ianov L, Winters BD, Walters BJ, Davidoff AM, Mitchell JA, Zovkic IB
2022, Communications Biology, 10.1038/s42003-022-03435-4

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Advanced In vivo Use of CRISPR/Cas9 and Anti-sense DNA Inhibition for Gene Manipulation in the Brain

Walters BJ, Azam AB, Gillon CJ, Josselyn SA, Zovkic IB
2015, Frontiers in genetics, 6, 362, 26793235

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H2A.Z helps genes remember their history so we can remember ours

Zovkic IB, Walters BJ
2015, BioEssays : news and reviews in molecular, cellular and developmental biology, 25880368

Memory-Associated Dynamic Regulation of the “Stable” Core of the Chromatin Particle

Zovkic IB, Sweatt JD
2015, Neuron, 87, 1-4, 26139363

Building up and knocking down: An emerging role for epigenetics and proteasomal degradation in systems consolidation

Walters BJ, Zovkic IB
2015, Neuroscience, 300, 39-52, 25967264

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Histone H2A.Z subunit exchange controls consolidation of recent and remote memory

Zovkic IB, Paulukaitis BS, Day JJ, Etikala DM, Sweatt JD
2014, Nature, 515, 582-6, 25219850

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Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD

Zovkic IB, Meadows JP, Kaas GA, Sweatt JD
2013, Frontiers in psychiatry, 4, 60, 23805109

Epigenetic regulation of memory formation and maintenance

Zovkic IB, Guzman-Karlsson MC, Sweatt JD
2013, Learning & memory (Cold Spring Harbor, N.Y.), 20, 61-74, 23322554

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Role of medial prefrontal cortex dopamine in age differences in response to amphetamine in rats: locomotor activity after intra-mPFC injections of dopaminergic ligands

Mathews IZ, McCormick CM
2012, Developmental neurobiology, 72, 1415-21, 22081646

Epigenetic mechanisms in learned fear: implications for PTSD

Zovkic IB, Sweatt JD
2013, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38, 77-93, 22692566

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Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood

McCormick CM, Thomas CM, Sheridan CS, Nixon F, Flynn JA, Mathews IZ
2012, Hippocampus, 22, 1300-12, 21805526

Heightened locomotor-activating effects of amphetamine administered into the nucleus accumbens in adolescent rats

Mathews IZ, Brudzynski SM, McCormick CM
2011, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 29, 501-7, 21616135

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Low doses of amphetamine lead to immediate and lasting locomotor sensitization in adolescent, not adult, male rats

Mathews IZ, Kelly H, McCormick CM
2011, Pharmacology, biochemistry, and behavior, 97, 640-6, 21108958

Enduring deficits in contextual and auditory fear conditioning after adolescent, not adult, social instability stress in male rats

Morrissey MD, Mathews IZ, McCormick CM
2011, Neurobiology of learning and memory, 95, 46-56, 20970512

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Individual differences in activity predict locomotor activity and conditioned place preference to amphetamine in both adolescent and adult rats

Mathews IZ, Morrissey MD, McCormick CM
2010, Pharmacology, biochemistry, and behavior, 95, 63-71, 20006968

Adolescent development, hypothalamic-pituitary-adrenal function, and programming of adult learning and memory

McCormick CM, Mathews IZ
2010, Progress in neuro-psychopharmacology & biological psychiatry, 34, 756-65, 19782715

Investigations of HPA function and the enduring consequences of stressors in adolescence in animal models

McCormick CM, Mathews IZ, Thomas C, Waters P
2010, Brain and cognition, 72, 73-85, 19616355

Changes in hyporesponsiveness to acute amphetamine and age differences in tyrosine hydroxylase immunoreactivity in the brain over adolescence in male and female rats

Mathews IZ, Waters P, McCormick CM
2009, Developmental psychobiology, 51, 417-28, 19492363

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Chronic social stress in adolescence influenced both amphetamine conditioned place preference and locomotor sensitization

Mathews IZ, Mills RG, McCormick CM
2008, Developmental psychobiology, 50, 451-9, 18551462

Increased depressive behaviour in females and heightened corticosterone release in males to swim stress after adolescent social stress in rats

Mathews IZ, Wilton A, Styles A, McCormick CM
2008, Behavioural brain research, 190, 33-40, 18342957

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Female and male rats in late adolescence differ from adults in amphetamine-induced locomotor activity, but not in conditioned place preference for amphetamine

Mathews IZ, McCormick CM
2007, Behavioural pharmacology, 18, 641-50, 17912048

Effects of chronic social stress in adolescence on anxiety and neuroendocrine response to mild stress in male and female rats

McCormick CM, Smith C, Mathews IZ
2008, Behavioural brain research, 187, 228-38, 17945360

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HPA function in adolescence: role of sex hormones in its regulation and the enduring consequences of exposure to stressors

McCormick CM, Mathews IZ
2007, Pharmacology, biochemistry, and behavior, 86, 220-33, 16901532

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