Jimmy Fraigne

Assistant Professor


Campus

St. George (downtown)

CSB Appointment

Teaching

Research Areas

Animal Biology, Bioinformatics / Computational Biology, Neurobiology, Pathology, Physiology, Science Pedagogy

Education

B.Sc. University of Poitiers 2003
M.Sc. University of Poitiers 2005
Ph.D. Texas Tech University Health Sciences Center 2010

Graduate Programs

Cell and Systems Biology

Research Description

My research aims to determine how neural circuits control sleep and motor behaviour. Some of the questions that I focus on are: How does the nervous system couple cortical arousal with the appropriate motor activity to produce meaningful behaviour? How are REM sleep and its characteristics generated and controlled? Our lab uses a range of techniques such as optogenetics, chemogenetics and live cell imaging to understand how and why pathology in sleep circuitry contributes to sleep disorders and neurodegenerative diseases.
My teaching focuses on promoting scientific literacy through active learning. I believe that scientific literacy helps students develop their critical thinking skills, knowledge, and curiosity. I integrate experiential learning in data science to my teaching, to give hands-on experience to students. I am recently exploring the use of generative AI to improve learning experiences for all students and creating tools for AI-assisted coding. Finally, I strive to create an inclusive and engaging learning environment that makes students feel at ease.


Contact Information

Office Phone: 416-946-5564
Office: RW 278
Lab: RW 315, RW 380
Lab Phone: 416-978-5652
Email

Mailing Address

25 Harbord Street,
Toronto, Ontario,
M5S 3G5

Visit lab’s website


Publications

2024

Sleep: How stress keeps you up at night

Luke R, Fraigne JJ, Peever J
2024, Current Biology, 10.1016/j.cub.2023.11.052

Hypocretin receptor antagonists prevent opioid addiction

Fraigne JJ, Peever JH
2024, Nature Mental Health, 10.1038/s44220-024-00300-7

REM sleep: Out-dreaming fear

Dugan BJ, Fraigne JJ, Peever J
2024, Current Biology, 10.1016/j.cub.2024.04.033

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2023

Immortal orexin cell transplants restore motor-arousal synchrony during cataplexy

Pintwala SK, Fraigne JJ, Belsham DD, Peever JH
2023, Current Biology, 10.1016/j.cub.2023.03.077

A novel machine learning system for identifying sleep–wake states in mice

Fraigne JJ, Wang J, Lee H, Luke R, Pintwala SK, Peever JH
2023, SLEEP, 10.1093/sleep/zsad101

Dopamine neurons in the ventral tegmental area modulate rapid eye movement sleep

Fraigne JJ, Luppi PH, Mahoney CE, De Luca R, Shiromani PJ, Weber F, Adamantidis A, Peever J
2023, SLEEP, 10.1093/sleep/zsad024

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2021

Neuroscience: Glutamate neurons in the medial septum control wakefulness

Taksokhan A, Fraigne J, Peever J
2021, Current Biology, 10.1016/j.cub.2021.03.006

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2019

Newly identified sleep–wake and circadian circuits as potential therapeutic targets

Venner A, Todd WD, Fraigne J, Bowrey H, Eban-Rothschild A, Kaur S, Anaclet C
2019, Sleep, 10.1093/sleep/zsz023

The Sublaterodorsal Tegmental Nucleus Functions to Couple Brain State and Motor Activity during REM Sleep and Wakefulness

Torontali ZA, Fraigne JJ, Sanghera P, Horner R, Peever J
2019, Current Biology, 10.1016/j.cub.2019.09.026

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2017

Activation of the Hypoglossal to Tongue Musculature Motor Pathway by Remote Control

Horton GA, Fraigne JJ, Torontali ZA, Snow MB, Lapierre JL, Liu H, Montandon G, Peever JH, Horner RL
2017, Scientific Reports, 10.1038/srep45860

GABA Cells in the Central Nucleus of the Amygdala Promote Cataplexy

Snow MB, Fraigne JJ, Thibault-Messier G, Chuen VL, Thomasian A, Horner RL, Peever J
2017, The Journal of Neuroscience, 10.1523/JNEUROSCI.4070-15.2017

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2015

REM Sleep at its Core – Circuits, Neurotransmitters, and Pathophysiology

Fraigne JJ, Torontali ZA, Snow MB, Peever JH
2015, Frontiers in Neurology, 10.3389/fneur.2015.00123

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2014

Mechanisms of REM sleep in health and disease

Fraigne JJ, Grace KP, Horner RL, Peever J
2014, Current Opinion in Pulmonary Medicine, 10.1097/MCP.0000000000000103

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2013

Brain Biology: Jerked Around by Sleep

Fraigne J, Peever J
2013, Current Biology, 10.1016/j.cub.2013.09.009

Melanin-Concentrating Hormone Neurons Promote and Stabilize Sleep

Fraigne JJ, Peever JH
2013, Sleep, 10.5665/sleep.3186

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2012

Tonic and phasic drive to medullary respiratory neurons during periodic breathing

Lovering AT, Fraigne JJ, Dunin-Barkowski WL, Vidruk EH, Orem JM
2012, Respiratory Physiology & Neurobiology, 10.1016/j.resp.2012.03.012

Sleep Biology: Tuning In While Tuned Out

Fraigne J, Peever J
2012, Current Biology, 10.1016/j.cub.2012.10.011

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2011

Phasic Motor Activity of Respiratory and Non-Respiratory Muscles in REM Sleep

Fraigne JJ, Orem JM
2011, Sleep, 10.1093/sleep/34.4.425

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2006

Medullary Respiratory Neural Activity During Hypoxia in NREM and REM Sleep in the Cat

Lovering AT, Fraigne JJ, Dunin-Barkowski WL, Vidruk EH, Orem JM
2006, Journal of Neurophysiology, 10.1152/jn.00615.2005

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2003

Hypocapnia Decreases the Amount of Rapid Eye Movement Sleep in Cats

Lovering AT, Fraigne JJ, Witali L. D, Vidruk EH, Orem JM
2003, Sleep, 10.1093/sleep/26.8.961

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