Jimmy Fraigne
Assistant Professor
Campus
St. George (downtown)
CSB Appointment
Teaching
Research Areas
Animal Biology, Bioinformatics / Computational Biology, Neurobiology, Pathology, Physiology, Science Pedagogy
Education
B.Sc. University of Poitiers 2003
M.Sc. University of Poitiers 2005
Ph.D. Texas Tech University Health Sciences Center 2010
Graduate Programs
Cell and Systems Biology
Research Description
My research aims to determine how neural circuits control sleep and motor behaviour. Some of the questions that I focus on are: How does the nervous system couple cortical arousal with the appropriate motor activity to produce meaningful behaviour? How are REM sleep and its characteristics generated and controlled? Our lab uses a range of techniques such as optogenetics, chemogenetics and live cell imaging to understand how and why pathology in sleep circuitry contributes to sleep disorders and neurodegenerative diseases.
My teaching focuses on promoting scientific literacy through active learning. I believe that scientific literacy helps students develop their critical thinking skills, knowledge, and curiosity. I integrate experiential learning in data science to my teaching, to give hands-on experience to students. I am recently exploring the use of generative AI to improve learning experiences for all students and creating tools for AI-assisted coding. Finally, I strive to create an inclusive and engaging learning environment that makes students feel at ease.
Contact Information
Office Phone: 416-946-5564
Office: RW 278
Lab: RW 315, RW 380
Lab Phone: 416-978-5652
Email
Mailing Address
25 Harbord Street,
Toronto, Ontario,
M5S 3G5
Publications
2024
Sleep: How stress keeps you up at night
Luke R, Fraigne JJ, Peever J
2024, Current Biology, 10.1016/j.cub.2023.11.052
Hypocretin receptor antagonists prevent opioid addiction
Fraigne JJ, Peever JH
2024, Nature Mental Health, 10.1038/s44220-024-00300-7
REM sleep: Out-dreaming fear
Dugan BJ, Fraigne JJ, Peever J
2024, Current Biology, 10.1016/j.cub.2024.04.033
2023
Immortal orexin cell transplants restore motor-arousal synchrony during cataplexy
Pintwala SK, Fraigne JJ, Belsham DD, Peever JH
2023, Current Biology, 10.1016/j.cub.2023.03.077
A novel machine learning system for identifying sleep–wake states in mice
Fraigne JJ, Wang J, Lee H, Luke R, Pintwala SK, Peever JH
2023, SLEEP, 10.1093/sleep/zsad101
Dopamine neurons in the ventral tegmental area modulate rapid eye movement sleep
Fraigne JJ, Luppi PH, Mahoney CE, De Luca R, Shiromani PJ, Weber F, Adamantidis A, Peever J
2023, SLEEP, 10.1093/sleep/zsad024
2021
Neuroscience: Glutamate neurons in the medial septum control wakefulness
Taksokhan A, Fraigne J, Peever J
2021, Current Biology, 10.1016/j.cub.2021.03.006
2019
Newly identified sleep–wake and circadian circuits as potential therapeutic targets
Venner A, Todd WD, Fraigne J, Bowrey H, Eban-Rothschild A, Kaur S, Anaclet C
2019, Sleep, 10.1093/sleep/zsz023
The Sublaterodorsal Tegmental Nucleus Functions to Couple Brain State and Motor Activity during REM Sleep and Wakefulness
Torontali ZA, Fraigne JJ, Sanghera P, Horner R, Peever J
2019, Current Biology, 10.1016/j.cub.2019.09.026
2017
Activation of the Hypoglossal to Tongue Musculature Motor Pathway by Remote Control
Horton GA, Fraigne JJ, Torontali ZA, Snow MB, Lapierre JL, Liu H, Montandon G, Peever JH, Horner RL
2017, Scientific Reports, 10.1038/srep45860
GABA Cells in the Central Nucleus of the Amygdala Promote Cataplexy
Snow MB, Fraigne JJ, Thibault-Messier G, Chuen VL, Thomasian A, Horner RL, Peever J
2017, The Journal of Neuroscience, 10.1523/JNEUROSCI.4070-15.2017
2015
REM Sleep at its Core – Circuits, Neurotransmitters, and Pathophysiology
Fraigne JJ, Torontali ZA, Snow MB, Peever JH
2015, Frontiers in Neurology, 10.3389/fneur.2015.00123
2014
Mechanisms of REM sleep in health and disease
Fraigne JJ, Grace KP, Horner RL, Peever J
2014, Current Opinion in Pulmonary Medicine, 10.1097/MCP.0000000000000103
2013
Brain Biology: Jerked Around by Sleep
Fraigne J, Peever J
2013, Current Biology, 10.1016/j.cub.2013.09.009
Melanin-Concentrating Hormone Neurons Promote and Stabilize Sleep
Fraigne JJ, Peever JH
2013, Sleep, 10.5665/sleep.3186
2012
Tonic and phasic drive to medullary respiratory neurons during periodic breathing
Lovering AT, Fraigne JJ, Dunin-Barkowski WL, Vidruk EH, Orem JM
2012, Respiratory Physiology & Neurobiology, 10.1016/j.resp.2012.03.012
Sleep Biology: Tuning In While Tuned Out
Fraigne J, Peever J
2012, Current Biology, 10.1016/j.cub.2012.10.011
2011
Phasic Motor Activity of Respiratory and Non-Respiratory Muscles in REM Sleep
Fraigne JJ, Orem JM
2011, Sleep, 10.1093/sleep/34.4.425
2006
Medullary Respiratory Neural Activity During Hypoxia in NREM and REM Sleep in the Cat
Lovering AT, Fraigne JJ, Dunin-Barkowski WL, Vidruk EH, Orem JM
2006, Journal of Neurophysiology, 10.1152/jn.00615.2005