John H. Peever
Professor
Campus
St. George (downtown)
CSB Appointment
Full
Research Areas
Animal Biology, Molecular Biology, Neurobiology, Pathology, Physiology, Systems Biology
Education
Ph.D. University of Toronto 2001
Titles and Honors
CIHR Research Fellow
Primary Undergraduate Department
Cell & Systems Biology
Graduate Programs
Cell & Systems Biology
Academic or Administrative Appointments
Director Centre for Biology Timing and Cognition
Associate Chair Graduate Studies, Department of Cell and Systems Biology
Associate Journal Editor @ Sleep and Frontiers in Neuroscience
VP Research Canadian Sleep Society
Research Description
Our research explores how the brain controls sleep and why changes in sleep control contribute to neurological disorders. My lab uses optogenetics, chemogenetics and live cell imaging to interrogate the brain circuits that control sleep, particularly REM sleep. Our research is also focussed on understanding how and why pathology in sleep circuitry contributes to sleep disorders (e.g., narcolepsy and REM sleep behavior disorder), and neurodegenerative diseases (e.g., Parkinson’s disease and dementia).
Contact Information
Office Phone: 416-946-5564
Office: 325 Huron St, Room 278a
Lab: 325 Huron St, Room 278 & 307
Lab Phone: 416-946-7236
Email
Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada
Recent News
Publications
2023
Immortal orexin cell transplants restore motor-arousal synchrony during cataplexy
Pintwala SK, Fraigne JJ, Belsham DD, Peever JH
2023, Current Biology, 10.1016/j.cub.2023.03.077
2021
Neuroscience: Glutamate neurons in the medial septum control wakefulness
Taksokhan A, Fraigne J, Peever J
2021, Current Biology, 10.1016/j.cub.2021.03.006
Brain Circuits Underlying Narcolepsy
Pintwala SK, Peever J
2021, The Neuroscientist, 10.1177/10738584211052263
2020
2019
Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy.
Szabo ST, Thorpy MJ, Mayer G, Peever JH, Kilduff TS
2019, Sleep medicine reviews, 43, 23-36, 30503715
The Sublaterodorsal Tegmental Nucleus Functions to Couple Brain State and Motor Activity during REM Sleep and Wakefulness
Torontali ZA, Fraigne JJ, Sanghera P, Horner R, Peever J
2019, Current Biology, 10.1016/j.cub.2019.09.026
2018
Brainstem Nuclei Associated with Mediating Apnea-Induced Respiratory Motor Plasticity.
Lui S, Torontali Z, Tadjalli A, Peever J
2018, Scientific reports, 8, 12709, 30139983
Neuroscience: A ‘Skin Warming’ Circuit that Promotes Sleep and Body Cooling.
Peever J
2018, Current biology : CB, 28, R800-R802, 30040944
2017
Brain Circuitry Controlling Sleep and Wakefulness.
Horner RL, Peever JH
2017, Continuum (Minneapolis, Minn.), 23, 955-972, 28777170
Degeneration of rapid eye movement sleep circuitry underlies rapid eye movement sleep behavior disorder.
McKenna D, Peever J
2017, Movement disorders : official journal of the Movement Disorder Society, 32, 636-644, 28394031
Circuit mechanisms of sleepiness and cataplexy in narcolepsy.
Pintwala S, Peever J
2017, Current opinion in neurobiology, 44, 50-58, 28343142
GABA Cells in the Central Nucleus of the Amygdala Promote Cataplexy.
Snow MB, Fraigne JJ, Thibault-Messier G, Chuen VL, Thomasian A, Horner RL, Peever J
2017, The Journal of neuroscience : the official journal of the Society for Neuroscience, 37, 4007-4022, 28209737
2016
Monoamine Release during Unihemispheric Sleep and Unihemispheric Waking in the Fur Seal
Lyamin OI, Lapierre JL, Kosenko PO, Kodama T, Bhagwandin A, Korneva SM, Peever JH, Mukhametov LM, Siegel JM
2016, Sleep, 39, 625-36, 26715233
2014
Noradrenergic modulation of masseter muscle activity during natural rapid eye movement sleep requires glutamatergic signalling at the trigeminal motor nucleus
Schwarz PB, Mir S, Peever JH
2014, The Journal of physiology, 24860176
Cataplexy-clinical aspects, pathophysiology and management strategy
Dauvilliers Y, Siegel JM, Lopez R, Torontali ZA, Peever JH
2014, Nature reviews. Neurology, 10, 386-95, 24890646
Cholinergic involvement in control of REM sleep paralysis
Torontali ZA, Grace KP, Horner RL, Peever JH
2014, The Journal of physiology, 592, 1425-6, 24692459
2013
Melanin-concentrating hormone neurons promote and stabilize sleep
Fraigne JJ, Peever JH
2013, Sleep, 36, 1767-8, 24293745
Brain biology: jerked around by sleep
Fraigne JJ, Peever JH
2013, Current biology : CB, 23, R954-6, 24200321
A noradrenergic mechanism functions to couple motor behavior with arousal state
Burgess CR, Peever JH
2013, Current biology : CB, 23, 1719-25, 23993842
Amygdala lesions reduce cataplexy in orexin knock-out mice
Burgess CR, Oishi Y, Mochizuki T, Peever JH, Scammell TE
2013, The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 9734-42, 23739970
Symmetrical serotonin release during asymmetrical slow-wave sleep: implications for the neurochemistry of sleep-waking states
Lapierre JL, Kosenko PO, Kodama T, Peever JH, Mukhametov LM, Lyamin OI, Siegel JM
2013, The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 2555-61, 23392683
2012
Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis
Brooks PL, Peever JH
2012, The Journal of neuroscience : the official journal of the Society for Neuroscience, 32, 9785-95, 22815493
2011
Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump
Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess CR, Petersen J, Jarowek KJ, Yücel YH, Cortez MA, Snead OC, Vilsen B, Peever JH, Ralph MR, Roder JC
2011, Proceedings of the National Academy of Sciences of the United States of America, 108, 18144-9, 22025725
Dopamine triggers skeletal muscle tone by activating D1-like receptors on somatic motoneurons
Schwarz PB, Peever JH
2011, Journal of neurophysiology, 106, 1299-309, 21653722
Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice
Brooks PL, Peever JH
2011, The Journal of neuroscience : the official journal of the Society for Neuroscience, 31, 7111-21, 21562273
2010
Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy
Burgess CR, Tse G, Gillis L, Peever JH
2010, Sleep, 33, 1295-304, 21061851
Noradrenergic control of trigeminal motoneurons in sleep: relevance to sleep apnea
Schwarz PB, Peever JH
2010, Advances in experimental medicine and biology, 669, 281-4, 20217366
GABAergic and glycinergic control of upper airway motoneurons in rapid eye movement sleep
Brooks PL, Peever JH
2010, Advances in experimental medicine and biology, 669, 259-62, 20217361
2008
Noradrenaline triggers muscle tone by amplifying glutamate-driven excitation of somatic motoneurones in anaesthetized rats
Schwarz PB, Yee N, Mir S, Peever JH
2008, The Journal of physiology, 586, 5787-802, 18845613
Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia
Brooks PL, Peever JH
2008, The Journal of neuroscience : the official journal of the Society for Neuroscience, 28, 3535-45, 18385312
Biochemical control of airway motor neurons during rapid eye movement sleep
Brooks PL, Peever JH
2008, Advances in experimental medicine and biology, 605, 437-41, 18085313
2003
Connections between respiratory neurones in the neonatal rat transverse medullary slice studied with cross-correlation
Li YM, Shen L, Peever JH, Duffin J
2003, The Journal of physiology, 549, 327-32, 12692183
Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism
Peever JH, Lai YY, Siegel JM
2003, Journal of neurophysiology, 89, 2591-600, 12611960
2002
Acetazolamide and respiratory chemosensitivity to CO(2) in the neonatal rat transverse medullary slice
Necakov A, Peever JH, Shen L, Duffin J
2002, Respiratory physiology & neurobiology, 132, 279-87, 12208086