Professor John Peever

John H. Peever

Professor


Campus

St. George (downtown)

CSB Appointment

Full

Research Areas

Animal Biology, Molecular Biology, Neurobiology, Pathology, Physiology, Systems Biology

Education

Ph.D. University of Toronto 2001

Titles and Honors

CIHR Research Fellow

Primary Undergraduate Department

Cell & Systems Biology

Graduate Programs

Cell & Systems Biology

Academic or Administrative Appointments

Director Centre for Biology Timing and Cognition
VP Research Canadian Sleep Society

Research Description

Our research aims to understand how the brain generates and regulates behavioral arousal states. My research team uses optogenetic and pharmacogenetic methods to dissect the brain circuitry controlling behavioral arousal state, particularly sleep. This work will not only identify the pathways that trigger sleep and wakefulness, it will also be invaluable in understanding how breakdown in brain circuits contributes to sleep disorders such as narcolepsy and REM sleep behavior disorder.


Contact Information

Office Phone: 416-946-5564
Office: RW315B
Lab: RW307/RW314/RW315
Lab Phone: 416-946-7236 / 416-946-7235 / 416-946-7240
Email

Mailing Address

Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada

Visit lab’s website


Recent News

CSB neurobiologists identify switch that turns muscles on and off during sleep

CSB Professor John Peever, CSB PhD grad Zoltan Torontali and CSB RA Jimmy Fraigne have demonstrated a new link between arousal and muscle paralysis…

Read More


Publications

2019

Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy.

Szabo ST, Thorpy MJ, Mayer G, Peever JH, Kilduff TS
2019, Sleep medicine reviews, 43, 23-36, 30503715

The Sublaterodorsal Tegmental Nucleus Functions to Couple Brain State and Motor Activity during REM Sleep and Wakefulness

Torontali ZA, Fraigne JJ, Sanghera P, Horner R, Peever J
2019, Current Biology, 10.1016/j.cub.2019.09.026

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2018

Brainstem Nuclei Associated with Mediating Apnea-Induced Respiratory Motor Plasticity.

Lui S, Torontali Z, Tadjalli A, Peever J
2018, Scientific reports, 8, 12709, 30139983

Neuroscience: A ‘Skin Warming’ Circuit that Promotes Sleep and Body Cooling.

Peever J
2018, Current biology : CB, 28, R800-R802, 30040944

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2017

The Biology of REM Sleep.

Peever J, Fuller PM
2017, Current biology : CB, 27, R1237-R1248, 29161567

Brain Circuitry Controlling Sleep and Wakefulness.

Horner RL, Peever JH
2017, Continuum (Minneapolis, Minn.), 23, 955-972, 28777170

Degeneration of rapid eye movement sleep circuitry underlies rapid eye movement sleep behavior disorder.

McKenna D, Peever J
2017, Movement disorders : official journal of the Movement Disorder Society, 32, 636-644, 28394031

Circuit mechanisms of sleepiness and cataplexy in narcolepsy.

Pintwala S, Peever J
2017, Current opinion in neurobiology, 44, 50-58, 28343142

GABA Cells in the Central Nucleus of the Amygdala Promote Cataplexy.

Snow MB, Fraigne JJ, Thibault-Messier G, Chuen VL, Thomasian A, Horner RL, Peever J
2017, The Journal of neuroscience : the official journal of the Society for Neuroscience, 37, 4007-4022, 28209737

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2016

Monoamine Release during Unihemispheric Sleep and Unihemispheric Waking in the Fur Seal

Lyamin OI, Lapierre JL, Kosenko PO, Kodama T, Bhagwandin A, Korneva SM, Peever JH, Mukhametov LM, Siegel JM
2016, Sleep, 39, 625-36, 26715233

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2014

Noradrenergic modulation of masseter muscle activity during natural rapid eye movement sleep requires glutamatergic signalling at the trigeminal motor nucleus

Schwarz PB, Mir S, Peever JH
2014, The Journal of physiology, 24860176

Cataplexy-clinical aspects, pathophysiology and management strategy

Dauvilliers Y, Siegel JM, Lopez R, Torontali ZA, Peever JH
2014, Nature reviews. Neurology, 10, 386-95, 24890646

Cholinergic involvement in control of REM sleep paralysis

Torontali ZA, Grace KP, Horner RL, Peever JH
2014, The Journal of physiology, 592, 1425-6, 24692459

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2013

Melanin-concentrating hormone neurons promote and stabilize sleep

Fraigne JJ, Peever JH
2013, Sleep, 36, 1767-8, 24293745

Brain biology: jerked around by sleep

Fraigne JJ, Peever JH
2013, Current biology : CB, 23, R954-6, 24200321

A noradrenergic mechanism functions to couple motor behavior with arousal state

Burgess CR, Peever JH
2013, Current biology : CB, 23, 1719-25, 23993842

Amygdala lesions reduce cataplexy in orexin knock-out mice

Burgess CR, Oishi Y, Mochizuki T, Peever JH, Scammell TE
2013, The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 9734-42, 23739970

Symmetrical serotonin release during asymmetrical slow-wave sleep: implications for the neurochemistry of sleep-waking states

Lapierre JL, Kosenko PO, Kodama T, Peever JH, Mukhametov LM, Lyamin OI, Siegel JM
2013, The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 2555-61, 23392683

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2012

Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis

Brooks PL, Peever JH
2012, The Journal of neuroscience : the official journal of the Society for Neuroscience, 32, 9785-95, 22815493

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2011

Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump

Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess CR, Petersen J, Jarowek KJ, Yücel YH, Cortez MA, Snead OC, Vilsen B, Peever JH, Ralph MR, Roder JC
2011, Proceedings of the National Academy of Sciences of the United States of America, 108, 18144-9, 22025725

Dopamine triggers skeletal muscle tone by activating D1-like receptors on somatic motoneurons

Schwarz PB, Peever JH
2011, Journal of neurophysiology, 106, 1299-309, 21653722

Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice

Brooks PL, Peever JH
2011, The Journal of neuroscience : the official journal of the Society for Neuroscience, 31, 7111-21, 21562273

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2010

Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy

Burgess CR, Tse G, Gillis L, Peever JH
2010, Sleep, 33, 1295-304, 21061851

Noradrenergic control of trigeminal motoneurons in sleep: relevance to sleep apnea

Schwarz PB, Peever JH
2010, Advances in experimental medicine and biology, 669, 281-4, 20217366

GABAergic and glycinergic control of upper airway motoneurons in rapid eye movement sleep

Brooks PL, Peever JH
2010, Advances in experimental medicine and biology, 669, 259-62, 20217361

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2008

Unraveling the mechanisms of REM sleep atonia

Brooks PL, Peever JH
2008, Sleep, 31, 1492-7, 19226735

Noradrenaline triggers muscle tone by amplifying glutamate-driven excitation of somatic motoneurones in anaesthetized rats

Schwarz PB, Yee N, Mir S, Peever JH
2008, The Journal of physiology, 586, 5787-802, 18845613

Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia

Brooks PL, Peever JH
2008, The Journal of neuroscience : the official journal of the Society for Neuroscience, 28, 3535-45, 18385312

Biochemical control of airway motor neurons during rapid eye movement sleep

Brooks PL, Peever JH
2008, Advances in experimental medicine and biology, 605, 437-41, 18085313

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2003

Connections between respiratory neurones in the neonatal rat transverse medullary slice studied with cross-correlation

Li YM, Shen L, Peever JH, Duffin J
2003, The Journal of physiology, 549, 327-32, 12692183

Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism

Peever JH, Lai YY, Siegel JM
2003, Journal of neurophysiology, 89, 2591-600, 12611960

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2002

Acetazolamide and respiratory chemosensitivity to CO(2) in the neonatal rat transverse medullary slice

Necakov A, Peever JH, Shen L, Duffin J
2002, Respiratory physiology & neurobiology, 132, 279-87, 12208086

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2001

Bilateral coordination of inspiratory neurones in the rat

Shen L, Peever JH, Duffin J
2002, Pflügers Archiv : European journal of physiology, 443, 829-35, 11889582

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