Mark Currie
Assistant Professor
Campus
UTM
CSB Appointment
Full
Research Areas
Cell Biology, Developmental Biology, Genetics / Genomics, Molecular Biology, Pathology, Proteomics, Structural Biology
Education
B.Sc. (Hons.) Queen’s University
Ph.D. Queen’s University
Primary Undergraduate Department
Biology, UTM
Graduate Programs
Cell & Systems Biology
Research Description
We seek to understand the mechanisms that govern genome organization, epigenetic gene regulation, and genome stability in health and disease. We combine structural biology, biochemistry, and cellular model systems.
Publications
For a complete list of publications, see PubMed.
Selected Publications
Targets of histone H3 lysine 9 methyltransferases
Levinsky AJ, McEdwards G, Sethna N, Currie MA
2022, Frontiers in Cell and Developmental Biology, 10.3389/fcell.2022.1026406
Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability
Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Moazed D
2018, Nature, 10.1038/s41586-018-0398-2
Contact Information
Office Phone: 905-828-3997
Office: DV3047
Lab: DV3015
Email
Mailing Address
Department of Cell & Systems Biology
University of Toronto
3359 Mississauga Rd,
Mississauga, ON L5L 1C6
Canada
Publications
2024
Mint/X11 PDZ domains from non-bilaterian animals recognize and bind CaV2 calcium channel C-termini in vitro
Harracksingh AN, Singh A, Mayorova TD, Bejoy B, Hornbeck J, Elkhatib W, McEdwards G, Gauberg J, Taha A, Islam IM, Erclik T, Currie MA, Noyes M, Senatore A
2024, Scientific Reports, 10.1038/s41598-024-70652-8
The binding of Mint/X11 PDZ domains to CaV2 calcium channels predates bilaterian animals
Harracksingh AN, Singh A, Mayorova T, Bejoy B, Hornbeck J, Elkhatib W, McEdwards G, Gauberg J, Taha ARW, Islam IM, Erclik T, Currie MA, Noyes M, Senatore A
2024, Cold Spring Harbor Laboratory - bioRxiv, 10.1101/2024.02.26.582151
Plastid ancestors lacked a complete Entner-Doudoroff pathway, limiting plants to glycolysis and the pentose phosphate pathway
Evans SE, Franks AE, Bergman ME, Sethna NS, Currie MA, Phillips MA
2024, Nature Communications, 10.1038/s41467-024-45384-y
Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation
Kailass K, Casalena D, Jenane L, McEdwards G, Auld DS, Sadovski O, Kaye EG, Hudson E, Nettleton D, Currie MA, Beharry AA
2024, Journal of Medicinal Chemistry, 10.1021/acs.jmedchem.3c01850
2023
The BAH domain: A versatile histone modification reader
Currie MA, Behrouzi R, Moazed D
2023, Chromatin Readers in Health and Disease, 10.1016/B978-0-12-823376-4.00006-9
Function and phylogeny support the independent evolution of an ASIC-like Deg/ENaC channel in the Placozoa
Elkhatib W, Yanez-Guerra LA, Mayorova TD, Currie MA, Singh A, Perera M, Gauberg J, Senatore A
2023, Communications Biology, 10.1038/s42003-023-05312-0
2022
Targets of histone H3 lysine 9 methyltransferases
Levinsky AJ, McEdwards G, Sethna N, Currie MA
2022, Frontiers in Cell and Developmental Biology, 10.3389/fcell.2022.1026406
Function and phylogeny support the independent evolution of acid-sensing ion channels in the Placozoa
Elkhatib W, Yanez-Guerra L, Mayorova TD, Currie MA, Perera M, Singh A, Gauberg J, Senatore A
2022, Cold Spring Harbor Laboratory - bioRxiv, 10.1101/2022.06.28.497943
2021
Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins
Wong SJ, Ringel AE, Yuan W, Paulo JA, Yoon H, Currie MA, Haigis MC
2021, Journal of Biological Chemistry, 10.1016/j.jbc.2021.100397
2018
Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability
Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Moazed D
2018, Nature, 10.1038/s41586-018-0398-2
2017
Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases
Currie MA, Brown G, Wong A, Ohira T, Sugiyama K, Suzuki T, Yakunin AF, Jia Z
2017, RNA, 10.1261/rna.057943.116
Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription
Jih G, Iglesias N, Currie MA, Bhanu NV, Paulo JA, Gygi SP, Garcia BA, Moazed D
2017, Nature, 10.1038/nature23267
2016
Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes
Behrouzi R, Lu C, Currie MA, Jih G, Iglesias N, Moazed D
2016, eLife, 10.7554/eLife.17556
2013
Small Angle X-ray Scattering Analysis ofClostridium thermocellumCellulosome N-terminal Complexes Reveals a Highly Dynamic Structure
Currie MA, Cameron K, Dias FMV, Spencer HL, Bayer EA, Fontes CMGA, Smith SP, Jia Z
2013, Journal of Biological Chemistry, 10.1074/jbc.M112.408757
Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA
Wang F, Li G, Altaf M, Lu C, Currie MA, Johnson A, Moazed D
2013, Proceedings of the National Academy of Sciences, 10.1073/pnas.1300126110
Structural basis of calcineurin activation by calmodulin
Ye Q, Feng Y, Yin Y, Faucher F, Currie MA, Rahman MN, Jin J, Li S, Wei Q, Jia Z
2013, Cellular Signalling, 10.1016/j.cellsig.2013.08.033
2012
Scaffoldin Conformation and Dynamics Revealed by a Ternary Complex from theClostridium thermocellumCellulosome
Currie MA, Adams JJ, Faucher F, Bayer EA, Jia Z, Smith SP
2012, Journal of Biological Chemistry, 10.1074/jbc.M112.343897
2010
Insights into Higher-Order Organization of the Cellulosome Revealed by a Dissect-and-Build Approach: Crystal Structure of Interacting Clostridium thermocellum Multimodular Components
Adams JJ, Currie MA, Ali S, Bayer EA, Jia Z, Smith SP
2010, Journal of Molecular Biology, 10.1016/j.jmb.2010.01.015
Purification and crystallization of a multimodular heterotrimeric complex containing both type I and type II cohesin–dockerin interactions from the cellulosome ofClostridium thermocellum
Currie MA, Adams JJ, Ali S, Smith SP, Jia Z
2010, Acta Crystallographica Section F Structural Biology and Crystallization Communications, 10.1107/S1744309110001375
2009
Preparation and Characterization of Bacterial Protein Complexes for Structural Analysis
Matte A, Kozlov G, Trempe J, Currie MA, Burk D, Jia Z, Gehring K, Ekiel I, Berghuis AM, Cygler M
2009, , 10.1016/S1876-1623(08)76001-2