Professor Mark Currie

Mark Currie

Assistant Professor



CSB Appointment


Research Areas

Cell Biology, Developmental Biology, Genetics / Genomics, Molecular Biology, Pathology, Proteomics, Structural Biology


B.Sc. (Hons.) Queen’s University

Ph.D. Queen’s University

Primary Undergraduate Department

Biology, UTM

Graduate Programs

Cell & Systems Biology

Research Description

We seek to understand the mechanisms that govern genome organization, epigenetic gene regulation, and genome stability in health and disease. We combine structural biology, biochemistry, and cellular model systems.

Contact Information

Office Phone: 905-828-3997
Office: DV3047
Lab: DV3015

Mailing Address

Department of Cell & Systems Biology
University of Toronto
3359 Mississauga Rd,
Mississauga, ON L5L 1C6

Visit lab’s website



Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability

Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Moazed D
2018, Nature, 10.1038/s41586-018-0398-2

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Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases

Currie MA, Brown G, Wong A, Ohira T, Sugiyama K, Suzuki T, Yakunin AF, Jia Z
2017, RNA, 10.1261/rna.057943.116

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription

Jih G, Iglesias N, Currie MA, Bhanu NV, Paulo JA, Gygi SP, Garcia BA, Moazed D
2017, Nature, 10.1038/nature23267

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Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes

Behrouzi R, Lu C, Currie MA, Jih G, Iglesias N, Moazed D
2016, eLife, 10.7554/eLife.17556

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Small Angle X-ray Scattering Analysis ofClostridium thermocellumCellulosome N-terminal Complexes Reveals a Highly Dynamic Structure

Currie MA, Cameron K, Dias FMV, Spencer HL, Bayer EA, Fontes CMGA, Smith SP, Jia Z
2013, Journal of Biological Chemistry, 10.1074/jbc.M112.408757

Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA

Wang F, Li G, Altaf M, Lu C, Currie MA, Johnson A, Moazed D
2013, Proceedings of the National Academy of Sciences, 10.1073/pnas.1300126110

Structural basis of calcineurin activation by calmodulin

Ye Q, Feng Y, Yin Y, Faucher F, Currie MA, Rahman MN, Jin J, Li S, Wei Q, Jia Z
2013, Cellular Signalling, 10.1016/j.cellsig.2013.08.033

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Scaffoldin Conformation and Dynamics Revealed by a Ternary Complex from theClostridium thermocellumCellulosome

Currie MA, Adams JJ, Faucher F, Bayer EA, Jia Z, Smith SP
2012, Journal of Biological Chemistry, 10.1074/jbc.M112.343897

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Insights into Higher-Order Organization of the Cellulosome Revealed by a Dissect-and-Build Approach: Crystal Structure of Interacting Clostridium thermocellum Multimodular Components

Adams JJ, Currie MA, Ali S, Bayer EA, Jia Z, Smith SP
2010, Journal of Molecular Biology, 10.1016/j.jmb.2010.01.015

Purification and crystallization of a multimodular heterotrimeric complex containing both type I and type II cohesin–dockerin interactions from the cellulosome ofClostridium thermocellum

Currie MA, Adams JJ, Ali S, Smith SP, Jia Z
2010, Acta Crystallographica Section F Structural Biology and Crystallization Communications, 10.1107/S1744309110001375

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Preparation and Characterization of Bacterial Protein Complexes for Structural Analysis

Matte A, Kozlov G, Trempe J, Currie MA, Burk D, Jia Z, Gehring K, Ekiel I, Berghuis AM, Cygler M
2009, , 10.1016/S1876-1623(08)76001-2

ADP-dependent 6-Phosphofructokinase fromPyrococcus horikoshiiOT3

Currie MA, Merino F, Skarina T, Wong AHY, Singer A, Brown G, Savchenko A, Caniuguir A, Guixé V, Yakunin AF, Jia Z
2009, Journal of Biological Chemistry, 10.1074/jbc.M109.012401

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