Mark Currie
Assistant Professor
Campus
UTM
CSB Appointment
Full
Research Areas
Cell Biology, Developmental Biology, Genetics / Genomics, Molecular Biology, Pathology, Proteomics, Structural Biology
Education
B.Sc. (Hons.) Queen’s University
Ph.D. Queen’s University
Primary Undergraduate Department
Biology, UTM
Graduate Programs
Cell & Systems Biology
Research Description
We seek to understand the mechanisms that govern genome organization, epigenetic gene regulation, and genome stability in health and disease. We combine structural biology, biochemistry, and cellular model systems.
Contact Information
Office Phone: 905-828-3997
Office: DV3047
Lab: DV3015
Email
Mailing Address
Department of Cell & Systems Biology
University of Toronto
3359 Mississauga Rd,
Mississauga, ON L5L 1C6
Canada
Publications
2018
Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability
Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Moazed D
2018, Nature, 10.1038/s41586-018-0398-2
2017
Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases
Currie MA, Brown G, Wong A, Ohira T, Sugiyama K, Suzuki T, Yakunin AF, Jia Z
2017, RNA, 10.1261/rna.057943.116
Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription
Jih G, Iglesias N, Currie MA, Bhanu NV, Paulo JA, Gygi SP, Garcia BA, Moazed D
2017, Nature, 10.1038/nature23267
2016
Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes
Behrouzi R, Lu C, Currie MA, Jih G, Iglesias N, Moazed D
2016, eLife, 10.7554/eLife.17556
2013
Small Angle X-ray Scattering Analysis ofClostridium thermocellumCellulosome N-terminal Complexes Reveals a Highly Dynamic Structure
Currie MA, Cameron K, Dias FMV, Spencer HL, Bayer EA, Fontes CMGA, Smith SP, Jia Z
2013, Journal of Biological Chemistry, 10.1074/jbc.M112.408757
Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA
Wang F, Li G, Altaf M, Lu C, Currie MA, Johnson A, Moazed D
2013, Proceedings of the National Academy of Sciences, 10.1073/pnas.1300126110
Structural basis of calcineurin activation by calmodulin
Ye Q, Feng Y, Yin Y, Faucher F, Currie MA, Rahman MN, Jin J, Li S, Wei Q, Jia Z
2013, Cellular Signalling, 10.1016/j.cellsig.2013.08.033
2012
Scaffoldin Conformation and Dynamics Revealed by a Ternary Complex from theClostridium thermocellumCellulosome
Currie MA, Adams JJ, Faucher F, Bayer EA, Jia Z, Smith SP
2012, Journal of Biological Chemistry, 10.1074/jbc.M112.343897
2010
Insights into Higher-Order Organization of the Cellulosome Revealed by a Dissect-and-Build Approach: Crystal Structure of Interacting Clostridium thermocellum Multimodular Components
Adams JJ, Currie MA, Ali S, Bayer EA, Jia Z, Smith SP
2010, Journal of Molecular Biology, 10.1016/j.jmb.2010.01.015
Purification and crystallization of a multimodular heterotrimeric complex containing both type I and type II cohesin–dockerin interactions from the cellulosome ofClostridium thermocellum
Currie MA, Adams JJ, Ali S, Smith SP, Jia Z
2010, Acta Crystallographica Section F Structural Biology and Crystallization Communications, 10.1107/S1744309110001375
2009
Preparation and Characterization of Bacterial Protein Complexes for Structural Analysis
Matte A, Kozlov G, Trempe J, Currie MA, Burk D, Jia Z, Gehring K, Ekiel I, Berghuis AM, Cygler M
2009, , 10.1016/S1876-1623(08)76001-2