Patrick O. McGowan
Associate Professor
Campus
UTSC
CSB Appointment
Full
Research Areas
Animal Biology, Genetics / Genomics, Neurobiology, Physiology, Systems Biology
Education
Ph.D. Duke University
B.Sc. Concordia University
Primary Undergraduate Department
Biological Sciences, UTSC
Graduate Programs
Cell & Systems Biology
Ecology & Evolutionary Biology
Research Description
Epigenetic mechanisms of neurodevelopment and behaviour. Focus on molecular mechanisms that mediate the adaptation to psychosocial stress and complex disease in humans and other species.
Contact Information
Office Phone: 416-208-5153
Office: SW548
Lab: SW526
Email
Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4
Canada
Publications
2014
DNA Methylation Modifications Associated with Chronic Fatigue Syndrome
de Vega WC, Vernon SD, McGowan PO
2014, PloS one, 9, e104757, 25111603
Cocaine exposure prior to pregnancy alters the psychomotor response to cocaine and transcriptional regulation of the dopamine D1 receptor in adult male offspring
Sasaki A, Constantinof A, Pan P, Kupferschmidt DA, McGowan PO, Erb S
2014, Behavioural brain research, 265, 163-70, 24583058
2013
Epigenomic Mechanisms of Early Adversity and HPA Dysfunction: Considerations for PTSD Research
McGowan PO
2013, Frontiers in psychiatry, 4, 110, 24133457
Biological embedding in mental health: an epigenomic perspective
Sasaki A, de Vega WC, McGowan PO
2013, Biochemistry and cell biology = Biochimie et biologie cellulaire, 91, 14-21, 23442137
2012
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus
Suderman M, McGowan PO, Sasaki A, Huang TC, Hallett MT, Meaney MJ, Turecki G, Szyf M
2012, Proceedings of the National Academy of Sciences of the United States of America, 109 Suppl 2, 17266-72, 23045659
Epigenetic clues to the biological embedding of early life adversity
McGowan PO
2012, Biological psychiatry, 72, 4-5, 22682394
2011
The Neurological Ecology of Fear: Insights Neuroscientists and Ecologists Have to Offer one Another
Clinchy M, Schulkin J, Zanette LY, Sheriff MJ, McGowan PO, Boonstra R
2010, Frontiers in behavioral neuroscience, 4, 21, 21629856
Broad epigenetic signature of maternal care in the brain of adult rats
McGowan PO, Suderman M, Sasaki A, Huang TC, Hallett M, Meaney MJ, Szyf M
2011, PloS one, 6, e14739, 21386994
Impaired social recognition memory in recombination activating gene 1-deficient mice
McGowan PO, Hope TA, Meck WH, Kelsoe G, Williams CL
2011, Brain research, 1383, 187-95, 21354115
2010
Environmental epigenomics: understanding the effects of parental care on the epigenome
McGowan PO, Szyf M
2010, Essays in biochemistry, 48, 275-87, 20822499
The epigenetics of social adversity in early life: implications for mental health outcomes
McGowan PO, Szyf M
2010, Neurobiology of disease, 39, 66-72, 20053376
2009
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ
2009, Nature neuroscience, 12, 342-8, 19234457
2008
Diet and the epigenetic (re)programming of phenotypic differences in behavior
McGowan PO, Meaney MJ, Szyf M
2008, Brain research, 1237, 12-24, 18694740
The effects of pH on DNA methylation state: In vitro and post-mortem brain studies
Ernst C, McGowan PO, Deleva V, Meaney MJ, Szyf M, Turecki G
2008, Journal of neuroscience methods, 174, 123-5, 18656499
Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain
McGowan PO, Sasaki A, Huang TC, Unterberger A, Suderman M, Ernst C, Meaney MJ, Turecki G, Szyf M
2008, PloS one, 3, e2085, 18461137