Rene E. Harrison
Professor
Campus
UTSC
CSB Appointment
Full
Research Areas
Cell Biology
Education
Ph.D. University of Toronto 2000 M.Sc. University of Manitoba 1996
Primary Undergraduate Department
Biological Sciences, UTSC
Graduate Programs
Cell & Systems Biology
Laboratory Medicine & Pathobiology
Academic or Administrative Appointments
Associate Chair for Research
Research Description
My lab uses advanced fluorescent imaging to study the cell biology of immune cells and bone cells under normal and pathological states.
Contact Information
Office Phone: 416-287-7377
Office: SW415A
Lab: SW422
Lab Phone: 416-287-7440
Email
Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4
Canada
Publications
2014
Modulation of osteoclastogenesis with macrophage m1- and m2-inducing stimuli
Jeganathan S, Fiorino C, Naik U, Sun HS, Harrison RE
2014, PloS one, 9, e104498, 25101660
2013
EB1 levels are elevated in ascorbic Acid (AA)-stimulated osteoblasts and mediate cell-cell adhesion-induced osteoblast differentiation
Pustylnik S, Fiorino C, Nabavi N, Zappitelli T, da Silva R, Aubin JE, Harrison RE
2013, The Journal of biological chemistry, 288, 22096-110, 23740245
Monocytes from patients with osteoarthritis display increased osteoclastogenesis and bone resorption: the In Vitro Osteoclast Differentiation in Arthritis study
Durand M, Komarova SV, Bhargava A, Trebec-Reynolds DP, Li K, Fiorino C, Maria O, Nabavi N, Manolson MF, Harrison RE, Dixon SJ, Sims SM, Mizianty MJ, Kurgan L, Haroun S, Boire G, de Fatima Lucena-Fernandes M, de Brum-Fernandes AJ
2013, Arthritis and rheumatism, 65, 148-58, 23044761
2012
Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts
Nabavi N, Pustylnik S, Harrison RE
2012, PloS one, 7, e46265, 23050002
Chlamydia trachomatis vacuole maturation in infected macrophages
Sun HS, Eng EW, Jeganathan S, Sin AT, Patel PC, Gracey E, Inman RD, Terebiznik MR, Harrison RE
2012, Journal of leukocyte biology, 92, 815-27, 22807527
Classically activated macrophages use stable microtubules for matrix metalloproteinase-9 (MMP-9) secretion
Hanania R, Sun HS, Xu K, Pustylnik S, Jeganathan S, Harrison RE
2012, The Journal of biological chemistry, 287, 8468-83, 22270361
2011
Chlamydia trachomatis inclusions induce asymmetric cleavage furrow formation and ingression failure in host cells
Sun HS, Wilde A, Harrison RE
2011, Molecular and cellular biology, 31, 5011-22, 21969606
Effects of microgravity on osteoclast bone resorption and osteoblast cytoskeletal organization and adhesion
Nabavi N, Khandani A, Camirand A, Harrison RE
2011, Bone, 49, 965-74, 21839189
Measuring immune receptor mobility by fluorescence recovery after photobleaching
Silver K, Harrison RE
2011, Methods in molecular biology (Clifton, N.J.), 748, 155-67, 21701973
2010
Kinesin 5B is necessary for delivery of membrane and receptors during FcγR-mediated phagocytosis
Silver KE, Harrison RE
2011, Journal of immunology (Baltimore, Md. : 1950), 186, 816-25, 21149599
Dynamic macrophage “probing” is required for the efficient capture of phagocytic targets
Flannagan RS, Harrison RE, Yip CM, Jaqaman K, Grinstein S
2010, The Journal of cell biology, 191, 1205-18, 21135140
2009
Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis
Botelho RJ, Harrison RE, Stone JC, Hancock JF, Philips MR, Jongstra-Bilen J, Mason D, Plumb J, Gold MR, Grinstein S
2009, The Journal of biological chemistry, 284, 28522-32, 19700408
Proteomic analysis of microtubule-associated proteins during macrophage activation
Patel PC, Fisher KH, Yang EC, Deane CM, Harrison RE
2009, Molecular & cellular proteomics : MCP, 8, 2500-14, 19651621
2008
Membrane ruffles capture C3bi-opsonized particles in activated macrophages
Patel PC, Harrison RE
2008, Molecular biology of the cell, 19, 4628-39, 18768756
Lysosome dispersion in osteoblasts accommodates enhanced collagen production during differentiation
Nabavi N, Urukova Y, Cardelli M, Aubin JE, Harrison RE
2008, The Journal of biological chemistry, 283, 19678-90, 18463099
2007
Cytoplasmic linker protein-170 enhances spreading and phagocytosis in activated macrophages by stabilizing microtubules
Binker MG, Zhao DY, Pang SJ, Harrison RE
2007, Journal of immunology (Baltimore, Md. : 1950), 179, 3780-91, 17785815
Microtubules regulate PI-3K activity and recruitment to the phagocytic cup during Fcgamma receptor-mediated phagocytosis in nonelicited macrophages
Khandani A, Eng E, Jongstra-Bilen J, Schreiber AD, Douda D, Samavarchi-Tehrani P, Harrison RE
2007, Journal of leukocyte biology, 82, 417-28, 17502337
MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages
Eng EW, Bettio A, Ibrahim J, Harrison RE
2007, Molecular biology of the cell, 18, 2389-99, 17442887
2005
Quantitative and dynamic assessment of the contribution of the ER to phagosome formation
Touret N, Paroutis P, Terebiznik M, Harrison RE, Trombetta S, Pypaert M, Chow A, Jiang A, Shaw J, Yip C, Moore HP, van der Wel N, Houben D, Peters PJ, de Chastellier C, Mellman I, Grinstein S
2005, Cell, 123, 157-70, 16213220
2004
Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria
Vieira OV, Harrison RE, Scott CC, Stenmark H, Alexander D, Liu J, Gruenberg J, Schreiber AD, Grinstein S
2004, Molecular and cellular biology, 24, 4593-604, 15121875
Salmonella impairs RILP recruitment to Rab7 during maturation of invasion vacuoles
Harrison RE, Brumell JH, Khandani A, Bucci C, Scott CC, Jiang X, Finlay BB, Grinstein S
2004, Molecular biology of the cell, 15, 3146-54, 15121880
Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton
Harrison RE, Sikorski BA, Jongstra J
2004, Journal of cell science, 117, 2151-7, 15090600
2003
Phagocytosis by neutrophils
Lee WL, Harrison RE, Grinstein S
2003, Microbes and infection / Institut Pasteur, 5, 1299-306, 14613773
Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP
Harrison RE, Bucci C, Vieira OV, Schroer TA, Grinstein S
2003, Molecular and cellular biology, 23, 6494-506, 12944476
Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase
Vieira OV, Bucci C, Harrison RE, Trimble WS, Lanzetti L, Gruenberg J, Schreiber AD, Stahl PD, Grinstein S
2003, Molecular and cellular biology, 23, 2501-14, 12640132
2002
Microbial killing: oxidants, proteases and ions
Harrison RE, Touret N, Grinstein S
2002, Current biology : CB, 12, R357-9, 12015137