Samira Ghorbani
Assistant Professor
Campus
UTM
CSB Appointment
Full
Research Areas
Cell Biology, Molecular Biology, Neurobiology, Pathology
Education
Ph.D in Immunology, Tehran University of Medical Sciences 2017
MSc, Isfahan University of Medical Sciences 2011
BSc, Tehran University 2007
Primary Undergraduate Department
Biology
Graduate Programs
Cell & Systems Biology
Immunology
Research Description
The age-related decline in CNS repair promotes axonal degeneration, which facilitate the transition to the progressive phase of multiple sclerosis (MS) from an earlier relapsing-remitting course. Most therapies in MS are based on immunomodulatory approaches with low efficacy in promoting repair. How to improve myelin repair is an active area of research with important health implications.
Our research aims to 1) advance our knowledge about the impediments of CNS repair including detrimental immune responses and altered composition of extracellular matrix proteins ; and 2) overcome these inhibitors to enhance repair and neuroprotection. We hope that our findings will not only contribute to the development of therapies that slow disease progression in MS but also provide valuable insights into addressing age-related neurodegenerative conditions.
Contact Information
Office Phone: 905-569-4751
Office: NSB3012
Lab: NSB3055
Email
Mailing Address
Department of Cell & Systems Biology
University of Toronto
3359 Mississauga Road
Mississauga, ON L5L 1C6
Canada
Publications
2024
Biology of neurofibrosis with focus on multiple sclerosis
Lozinski BM, Ghorbani S, Yong VW
2024, Frontiers in Immunology, 10.3389/fimmu.2024.1370107
Uncovering Novel Extracellular Matrix Transcriptome Alterations in Lesions of Multiple Sclerosis
Stephenson EL, Jain RW, Ghorbani S, Gorter RP, D’Mello C, Yong VW
2024, International Journal of Molecular Sciences, 10.3390/ijms25021240
2023
Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages
Zhang R, Dong Y, Liu Y, Moezzi D, Ghorbani S, Mirzaei R, Lozinski BM, Dunn JF, Yong VW, Xue M
2023, Stroke and Vascular Neurology, 10.1136/svn-2023-002331
Elevated Galectin-3 Is Associated with Aging, Multiple Sclerosis, and Oxidized Phosphatidylcholine-Induced Neurodegeneration
Xue S, Lozinski BM, Ghorbani S, Ta K, D\'Mello C, Yong VW, Dong Y
2023, The Journal of Neuroscience, 10.1523/JNEUROSCI.2312-22.2023
Vitamins A and D Enhance the Expression of Ror-γ-Targeting miRNAs in a Mouse Model of Multiple Sclerosis
Mohammadi-Kordkhayli M, Sahraian MA, Ghorbani S, Mansouri F, Talebi F, Noorbakhsh F, Saboor-Yaraghi AA
2023, Molecular Neurobiology, 10.1007/s12035-023-03427-3
The extracellular matrix as modifier of neuroinflammation and recovery in ischemic stroke and intracerebral hemorrhage
Li H, Ghorbani S, Ling C, Yong VW, Xue M
2023, Neurobiology of Disease, 10.1016/j.nbd.2023.106282
Prominent elevation of extracellular matrix molecules in intracerebral hemorrhage
Li H, Ghorbani S, Zhang R, Ebacher V, Stephenson EL, Keough MB, Yong VW, Xue M
2023, Frontiers in Molecular Neuroscience, 10.3389/fnmol.2023.1251432
2022
Expression of antioxidant enzymes in lesions of multiple sclerosis and its models
Moezzi D, Dong Y, Jain RW, Lozinski BM, Ghorbani S, D’Mello C, Wee Yong V
2022, Scientific Reports, 10.1038/s41598-022-16840-w
Single-cell and spatial RNA sequencing identify perturbators of microglial functions with aging
Dong Y, Jain RW, Lozinski BM, D’Mello C, Visser F, Ghorbani S, Zandee S, Brown DI, Prat A, Xue M, Yong VW
2022, Nature Aging, 10.1038/s43587-022-00205-z
Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination
Ghorbani S, Jelinek E, Jain R, Buehner B, Li C, Lozinski BM, Sarkar S, Kaushik DK, Dong Y, Wight TN, Karimi-Abdolrezaee S, Schenk GJ, Strijbis EM, Geurts J, Zhang P, Ling C, Yong VW
2022, Nature Communications, 10.1038/s41467-022-30032-0
2021
Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia
Dong Y, D’Mello C, Pinsky W, Lozinski BM, Kaushik DK, Ghorbani S, Moezzi D, Brown D, Melo FC, Zandee S, Vo T, Prat A, Whitehead SN, Yong VW
2021, Nature Neuroscience, 10.1038/s41593-021-00801-z
The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis
Ghorbani S, Yong VW
2021, Brain, 10.1093/brain/awab059
2020
The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination
Pu A, Mishra MK, Dong Y, Ghorbanigazar S, Stephenson EL, Rawji KS, Silva C, Kitagawa H, Sawcer S, Yong VW
2020, Journal of Neuroinflammation, 10.1186/s12974-020-01895-1
2019
Malat1 long noncoding RNA regulates inflammation and leukocyte differentiation in experimental autoimmune encephalomyelitis
Masoumi F, Ghorbani S, Talebi F, Branton WG, Rajaei S, Power C, Noorbakhsh F
2019, Journal of Neuroimmunology, 10.1016/j.jneuroim.2018.11.013
The benefits of neuroinflammation for the repair of the injured central nervous system
Yong HYF, Rawji KS, Ghorbani S, Xue M, Yong VW
2019, Cellular & Molecular Immunology, 10.1038/s41423-019-0223-3
Targeting the Chondroitin Sulfate Proteoglycans: Evaluating Fluorinated Glucosamines and Xylosides in Screens Pertinent to Multiple Sclerosis
Stephenson EL, Zhang P, Ghorbani S, Wang A, Gu J, Keough MB, Rawji KS, Silva C, Yong VW, Ling C
2019, ACS Central Science, 10.1021/acscentsci.9b00327
2018
MicroRNA-150 targets PU.1 and regulates macrophage differentiation and function in experimental autoimmune encephalomyelitis
Shakerian L, Ghorbani S, Talebi F, Noorbakhsh F
2018, Journal of Neuroimmunology, 10.1016/j.jneuroim.2018.06.010
MicroRNA-92a Drives Th1 Responses in the Experimental Autoimmune Encephalomyelitis
Rezaei N, Talebi F, Ghorbani S, Rezaei A, Esmaeili A, Noorbakhsh F, Hakemi MG
2018, Inflammation, 10.1007/s10753-018-0887-3
2017
MicroRNA-142 regulates inflammation and T cell differentiation in an animal model of multiple sclerosis
Talebi F, Ghorbani S, Chan WF, Boghozian R, Masoumi F, Ghasemi S, Vojgani M, Power C, Noorbakhsh F
2017, Journal of Neuroinflammation, 10.1186/s12974-017-0832-7
miR-181 interacts with signaling adaptor molecule DENN/MADD and enhances TNF-induced cell death
Ahmad M, Ghorbani S, Talebi F, Ghasemi S, Jahanbazi Jahan Abad A, Vojgani M, Noorbakhsh F
2017, PLOS ONE, 10.1371/journal.pone.0174368
MicroRNA-181 Variants Regulate T Cell Phenotype in the Context of Autoimmune Neuroinflammation
Ghorbani S, Talebi F, Chan WF, Masoumi F, Vojgani M, Power C, Noorbakhsh F
2017, Frontiers in Immunology, 10.3389/fimmu.2017.00758