Professor Susannah L. Varmuza

Susannah L. Varmuza

Professor Emerita


Campus

St. George (downtown)

CSB Appointment

Emeritus

Research Areas

Developmental Biology, Molecular Biology

Education

Ph.D. McMaster University, 1985

Primary Undergraduate Department

Cell & Systems Biology

Graduate Programs

Cell & Systems Biology

Academic or Administrative Appointments

Associate Chair for Undergraduate Studies

Research Description

My research area is Epigenetics, with a focus on genomic imprinting in mammals and its impact on development.


Contact Information

Office Phone: 416-978-2759
Office: RW537A
Lab: RW537
Lab Phone: 416-946-7220
Email

Mailing Address

Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada


Publications

2014

Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ

Opaluch AM, Schneider M, Chiang CY, Nguyen QT, Maestre AM, Mulder LC, Secundino I, De Jesus PD, König R, Simon V, Nizet V, MacLeod G, Varmuza S, Fernandez-Sesma A, Chanda SK
2014, PloS one, 9, e89284, 24586659

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2013

PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis

MacLeod G, Shang P, Booth GT, Mastropaolo LA, Manafpoursakha N, Vogl AW, Varmuza S
2014, Reproduction (Cambridge, England), 147, 1-12, 24088291

The imprinted polycomb group gene Sfmbt2 is required for trophoblast maintenance and placenta development

Miri K, Latham K, Panning B, Zhong Z, Andersen A, Varmuza S
2013, Development (Cambridge, England), 140, 4480-9, 24154523

The application of proteomic approaches to the study of mammalian spermatogenesis and sperm function

Macleod G, Varmuza S
2013, The FEBS journal, 280, 5635-51, 23902417

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2012

Tandem affinity purification in transgenic mouse embryonic stem cells identifies DDOST as a novel PPP1CC2 interacting protein

MacLeod G, Varmuza S
2012, Biochemistry, 51, 9678-88, 23140390

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2011

Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs

Wang Q, Chow J, Hong J, Smith AF, Moreno C, Seaby P, Vrana P, Miri K, Tak J, Chung ED, Mastromonaco G, Caniggia I, Varmuza S
2011, BMC genomics, 12, 204, 21510876

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2010

Loss of protein phosphatase 1c{gamma} (PPP1CC) leads to impaired spermatogenesis associated with defects in chromatin condensation and acrosome development: an ultrastructural analysis

Forgione N, Vogl AW, Varmuza S
2010, Reproduction (Cambridge, England), 139, 1021-9, 20385779

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2009

Metakaryotic stem cell lineages in organogenesis of humans and other metazoans

Gostjeva EV, Koledova V, Tomita-Mitchell A, Mitchell M, Goetsch MA, Varmuza S, Fomina JN, Darroudi F, Thilly WG
2009, Organogenesis, 5, 191-200, 20539738

Identification of potentially damaging amino acid substitutions leading to human male infertility

Kuzmin A, Jarvi K, Lo K, Spencer L, Chow GY, Macleod G, Wang Q, Varmuza S
2009, Biology of reproduction, 81, 319-26, 19369647

Imprinting and extraembryonic tissues-mom takes control

Miri K, Varmuza S
2009, International review of cell and molecular biology, 276, 215-62, 19584014

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2007

The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues

Kuzmin A, Han Z, Golding MC, Mann MR, Latham KE, Varmuza S
2008, Gene expression patterns : GEP, 8, 107-16, 18024232

A testis specific isoform of endophilin B1, endophilin B1t, interacts specifically with protein phosphatase-1c gamma2 in mouse testis and is abnormally expressed in PP1c gamma null mice

Hrabchak C, Henderson H, Varmuza S
2007, Biochemistry, 46, 4635-44, 17381077

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2004

Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis

Hrabchak C, Varmuza S
2004, The Journal of biological chemistry, 279, 37079-86, 15226296

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2003

Epigenetics and the renaissance of heresy

Varmuza S
2003, Genome / National Research Council Canada = Génome / Conseil national de recherches Canada, 46, 963-7; discussion 968-73, 14663513

Protein phosphatase 1cgamma is required in germ cells in murine testis

Oppedisano-Wells L, Varmuza S
2003, Molecular reproduction and development, 65, 157-66, 12704726

Increased recombination frequency showing evidence of loss of interference is associated with abnormal testicular histopathology

Varmuza S, Ling L
2003, Molecular reproduction and development, 64, 499-506, 12589662

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2002

Development to blastocyst is impaired when intracytoplasmic sperm injection is performed with abnormal sperm from infertile mice harboring a mutation in the protein phosphatase 1cgamma gene

Davies T, Varmuza S
2003, Biology of reproduction, 68, 1470-6, 12606345

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