Module: Structural Biology in Drug Development and Biotechnology
CSB1021H/S, Teaching Section LEC 0144
Coordinator
Professor Mark Currie
Offered Winter 2024 session for 9 weeks, starting on Tuesday, January 9th, 2024.
Enrollment limited to 12 students
Weight
One module (0.25 FCE)
Time
Tuesdays from 6-9 pm
Location
UTM campus, room TBA
Course Description
Biological, disease, and drug mechanisms are all determined by the three-dimensional arrangement of atoms within biological macromolecules. Therefore, knowledge of molecular structure is fundamental to protein engineering and the development of new therapeutics and vaccines. This course will cover the application of structural biology methods to drug development and biotechnology. Students will be introduced to the modern tools of protein structure determination including Cryo electron microscopy, X-ray crystallography, and NMR through lectures and tutorials. Lectures will focus on theory, techniques, and the advantages and limitations of each method. The applications of these methods to the pharmaceutical and biotechnology industries including protein engineering, target selection and drugability, lead identification and optimization, rational drug design, and drug mechanism of action will be explored through student presentations and discussions.
Evaluation
Presentations: 30%
Participation: 25%
Report: 20%
Tutorials: 15%
Quizzes: 10%
Last updated on August 10th, 2023