Kaori Takehara-Nishiuchi

faculty_img Academic Title: Associate Professor

Campus: St. George

CSB Appointment: Cross Appointment

Primary Undergraduate Department:

Graduate Programs:
Cell & Systems Biology

Titles and Honors:
Early Researcher Awards, Ministry of Ontario
Young Investigator Award, Japan Neuroscience Society

Academic or Administrative Appointments:
Ph.D. University of Tokyo 2006
M.Sc. University of Tokyo 2003
B.Sc. University of Tokyo 2001


Mailing Address
Department of Psychology
University of Toronto
100 St. George St.
Toronto, ON M5S 3G3


Contact Information
Office phone: 416-978-6570 
Office: SS 4007 
Lab: RW311 
Lab phone: 416-946-5540 
Email: takehara@psych.utoronto.ca 
URL: http://www.takeharalab.com/


Research Areas
Animal Biology
Psychology & Behavior



The overarching goal of my research team is to understand how neuronal networks produce normal and abnormal memory states. Specifically, I pursue two research aims: one is to reveal the functional architecture of the healthy memory system as it forms a permanent record of daily experiences (episodic memory), and the other is to show how the functional connectivity within this network becomes disrupted in Alzheimer’s disease. I methodologically approach these questions by employing novel, cutting-edge technologies specifically designed to probe and manipulate network activity in behaving animals. Recordings of multiple single neurons and local field potential signals while employing precise classical conditioning protocols provide the fundamental experimental framework. We enrich this framework with precisely controlled manipulations of neuronal pathways or gene expression with viral vectors. Together, our multidisciplinary approach will contribute to uncovering computations in cortical networks supporting episodic memory and their dysfunctions in memory disorders.







Neural representations of time-linked memory. Pilkiw M, Takehara-Nishiuchi K. Neurobiology of Learning and Memory, 2018 Mar 31. pii: S1074-7427(18)30078-9. doi: 10.1016/j.nlm.2018.03.024. [Epub ahead of print]
Aberrant Cortical Event-Related Potentials During Associative Learning in Rat Models for Presymptomatic Stages of Alzheimer’s Disease. Nouriziabari B, Sarkar S, Tanninen SE, Dayton R, Klein RL, Takehara-Nishiuchi K. J Alzheimers Dis. 2018;63(2):725-740. doi: 10.3233/JAD-171033.
Cholinergic Modulation of Frontoparietal Cortical Network Dynamics Supporting Supramodal Attention. Ljubojevic V, Luu P, Gill PR, Beckett LA, Takehara-Nishiuchi K, De Rosa E. J Neurosci. 2018 Apr 18;38(16):3988-4005. doi: 10.1523/JNEUROSCI.2350-17.2018. Epub 2018 Mar 23.



Phasic and tonic neuron ensemble codes for stimulus-environment conjunctions in the lateral entorhinal cortex. Pilkiw M, Insel N, Cui Y, Finney C, Morrissey MD, Takehara-Nishiuchi K. Elife. 2017 Jul 6;6. pii: e28611. doi: 10.7554/eLife.28611.
Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation. Xia F, Richards BA, Tran MM, Josselyn SA, Takehara-Nishiuchi K, Frankland PW. Elife. 2017 Sep 29;6. pii: e27868. doi: 10.7554/eLife.27868.
Entorhinal tau pathology disrupts hippocampal-prefrontal oscillatory coupling during associative learning. Tanninen SE, Nouriziabari B, Morrissey MD, Bakir R, Dayton RD, Klein RL,
Observational fear learning in degus is correlated with temporal vocalization patterns. Lidhar NK, Insel N, Dong JY, Takehara-Nishiuchi K. Behav Brain Res. 2017 Aug 14;332:362-371. doi: 10.1016/j.bbr.2017.06.011. Epub 2017 Jun 13.
Generalizable knowledge outweighs incidental details in prefrontal ensemble code over time. Morrissey MD, Insel N, Takehara-Nishiuchi K. Elife. 2017 Feb 14;6. pii: e22177. doi: 10.7554/eLife.22177.



Enhancing Prefrontal Neuron Activity Enables Associative Learning of Temporally Disparate Events. Volle J, Yu X, Sun H, Tanninen SE, Insel N, Takehara-Nishiuchi K. Cell Rep. 2016 Jun 14;15(11):2400-10. doi: 10.1016/j.celrep.2016.05.021. Epub 2016 Jun 2.