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CSB Departmental Seminar: Maintenance of Gene Expression States
January 31 @ 11:00 am - 12:00 pm
Professor and Graduate Advisor LeAnn Howe
Department of Biochemistry and Molecular Biology
The University of British Columbia
“Maintenance of Gene Expression States”
In multicellular organisms, the unique transcriptional program executed by each cell determines cellular identity. Indeed aberrant gene expression is a causal factor in many common human diseases, including cancer. While the availability of appropriate transcriptional activators or repressors determines whether a gene is transcribed, alteration of chromatin structure plays an important role in maintaining gene expression states. Chromatin is a nucleoprotein structure, consisting of DNA, histones, and non-histone proteins, which packages DNA in the eukaryotic nucleus. Our research uses a combination of molecular biology and bioinformatics to study the roles played by histones, histone chaperones, histone variants, and histone post-translational modifications in preserving active gene expression patterns.
Host: Jennifer Mitchell: email@example.com