Course Description

The development, structural integrity and physiological functions of tissues in animals are dependent on dynamic bidirectional crosstalk between cells and their extracellular matrix (ECM) microenvironments. The course examines the molecular design, biomechanical properties, and functions of collagens, proteoglycans, glycoproteins, and elastomeric proteins. Emphasis is placed on how they act in concert to form complex 3D matrices that promote tissue morphogenesis, growth and remodeling throughout life and how dysregulated ECM dynamics is the underlying cause of a broad spectrum of congenital disorders and pathological conditions such as tissue fibrosis and cancer. 


BIO230H1 / BIO255H1


Prof. M. Ringuette

Contact Hours


Evaluation (Subject to change)

Two term tests worth 30% each
A final exam worth 40%


Last updated on June 15th, 2022