|Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
|Office phone: 416-978-5328
Office: RW 514B
Lab: RW 509
Lab phone: 416-978-4153
Bioinformatics and Computational Biology
Most of the cells in an organism share the same genome sequence, yet they are able to carry out many distinct functions. Along with other layers of gene regulation, chromatin modification plays a key role in this cellular specialization. Our research focuses on histone modifications such as lysine methylation, and the proteins that recognize these modifications, which are often referred to as chromatin ‘readers’. Chromatin readers can recruit and act as part of diverse chromatin modifying protein complexes to mediate the silencing of many genes with important functions in cell proliferation and differentiation. We will use a combination of genetic, biochemical and genome-wide sequencing approaches to investigate the striking regulatory complexity of chromatin readers. Our research will contribute to a better understanding of how cells acquire and maintain different fates during development, how chromatin readers contribute to epigenetic inheritance, and how aberrant regulation of histone methylation contributes to the pathogenesis of several human diseases, including cancers.
|Transgenerational Epigenetic Inheritance Is Negatively Regulated by the HERI-1 Chromodomain Protein. Perales R, Pagano D, Wan G, Fields BD, Saltzman AL, Kennedy SG, Genetics. 2018 Nov 2. pii: genetics.301456.2018. doi: 10.1534/genetics.118.301456. [Epub ahead of print]
|Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in Caenorhabditis elegans. Saltzman AL, Soo MW, Aram R, Lee JT, Genetics. 2018 Nov;210(3):907-923. doi: 10.1534/genetics.118.301518. Epub 2018 Sep 5.