Dorothea Godt

faculty_img Academic Title: Associate Professor

Campus: St. George

CSB Appointment: Full

Primary Undergraduate Department:
Cell & Systems Biology

Graduate Programs:
Cell & Systems Biology
Developmental Biology

Titles and Honors:
Academic or Administrative Appointments:
Education:
Postdoctoral research 1991-1996, UCLA, USA Ph.D. 1990, University of Cologne, Germany Diploma 1985, Lud. Max. University Munich, Germany

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada

 

Contact Information
Office phone: 416-978-8714
Office: RW 608A
Lab: RW 608 / 609
Lab phone: 416-946-3691
Email: d.godt@utoronto.ca
URL: http://labs.csb.utoronto.ca/godt

 

Research Areas
Animal Biology
Cell Biology
Developmental Biology
Functional Genomics
Genetics
Molecular Biology

 

Research

The behavior of individual cells is the driving force behind morphogenesis. Cell shape, cell motility, cell-cell and cell-matrix interactions, which can undergo rapid changes during development, determine the shape and organization of tissues and organs. To identify and analyze the molecular pathways and networks that regulate the behavior of cells during morphogenesis my research group uses gonad development in Drosophila as a model system. Our research focuses on (1) the formation of the germline stem cell niche, (2) invasive cell migration in ovarian follicles, and (3) development of microvilli in epithelial cells.

 

Publications

2017

Top

Specification and spatial arrangement of cells in the germline stem cell niche of the Drosophila ovary depend on the Maf transcription factor Traffic jam.Panchal T, Chen X, Alchits E, Oh Y, Poon J, Kouptsova J, Laski FA, Godt D, PLoS Genet. 2017 May 19;13(5):e1006790. doi: 10.1371/journal.pgen.1006790. eCollection 2017 May.
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2016

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The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.Li, Tongchao, Nikolaos Giagtzoglou, Daniel F Eberl, Sonal Nagarkar Jaiswal, Tiantian Cai, Dorothea Godt, Andrew K Groves, and Hugo J Bellen. eLife (June 22) 2016. doi:10.7554/eLife.15258.
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2014

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Loss of SPARC dysregulates basal lamina assembly to disrupt larval fat body homeostasis in Drosophila melanogaster.Shahab J, Baratta C, Scuric B, Godt D, Venken KJ, Ringuette MJ.Dev. Dyn. 2014 Dec;
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Myosin VIIA regulates microvillus morphogenesis and interacts with cadherin Cad99C in Drosophila oogenesis.Glowinski C, Liu RH, Chen X, Darabie A, Godt D.J. Cell. Sci. 2014 Nov;127(22):4821-32
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2013

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The Maf factor Traffic jam both enables and inhibits collective cell migration in Drosophila oogenesis.Gunawan F, Arandjelovic M, Godt D.Development 2013 Jul;140(13):2808-17
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2012

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Mutational analysis supports a core role for Drosophila α-catenin in adherens junction function.Sarpal R, Pellikka M, Patel RR, Hui FY, Godt D, Tepass U.J. Cell. Sci. 2012 Jan;125(Pt 1):233-45
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2009

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Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration.Godt D, Tepass U.Nat. Cell Biol. 2009 May;11(5):536-8
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The germline stem cells of Drosophila melanogaster partition DNA non-randomly.Karpowicz P, Pellikka M, Chea E, Godt D, Tepass U, van der Kooy D.Eur. J. Cell Biol. 2009 Jul;88(7):397-408
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Cell dynamics and developmental bias in the ontogeny of a complex sexually dimorphic trait in Drosophila melanogaster.Atallah J, Liu NH, Dennis P, Hon A, Godt D, Larsen EW.Evol. Dev. 2009 Mar-Apr;11(2):191-204
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2008

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Expression profile of the cadherin family in the developing Drosophila brain.Fung S, Wang F, Chase M, Godt D, Hartenstein V.J. Comp. Neurol. 2008 Jan;506(3):469-88
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2007

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Integrin-dependent anchoring of a stem-cell niche.Tanentzapf G, Devenport D, Godt D, Brown NH.Nat. Cell Biol. 2007 Dec;9(12):1413-8
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2005

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Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli.D’Alterio C, Tran DD, Yeung MW, Hwang MS, Li MA, Arana CJ, Mulligan VK, Kubesh M, Sharma P, Chase M, Tepass U, Godt D.J. Cell Biol. 2005 Nov;171(3):549-58
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Talin’s second persona.Tepass U, Godt D.Nat. Cell Biol. 2005 May;7(5):443-4
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2003

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The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila.Li MA, Alls JD, Avancini RM, Koo K, Godt D.Nat. Cell Biol. 2003 Nov;5(11):994-1000
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Hand-me-downs. Transmitting anterior-posterior asymmetry from older to younger egg follicles.Godt D, Tepass U.Dev. Cell 2003 Oct;5(4):525-7
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Organogenesis: keeping in touch with the germ cells.Godt D, Tepass U.Curr. Biol. 2003 Sep;13(17):R683-5
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The Drosophila melanogaster BTB proteins bric à brac bind DNA through a composite DNA binding domain containing a pipsqueak and an AT-Hook motif.Lours C, Bardot O, Godt D, Laski FA, Couderc JL.Nucleic Acids Res. 2003 Sep;31(18):5389-98
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2002

Top

Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries.Tepass U, Godt D, Winklbauer R.Curr. Opin. Genet. Dev. 2002 Oct;12(5):572-82
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