CSB Seminar: Mapping Spatiotemporal Gene Regulatory Networks Guiding Root Vascular Development

CSB Special Seminar

Prof. Siobhan Brady
Dept of Plant Biology & Genome Center
University of California

“Mapping Spatiotemporal Gene Regulatory Networks Guiding Root Vascular Development”

Mallorie Taylor-Teeples, Miguel de Lucas, Allison Gaudinier, Ted Toal, Sebastian Ahnert, Francois Roudier, Siobhan M. Brady.

Arabidopsis root development provides a remarkably tractable system to delineate cell type-specific, developmental gene regulatory networks and to study their functionality in a complex multicellular model system over developmental time. We present gene regulatory networks guiding two aspects of vascular cell type development, specifically xylem cell specification and differentiation and vascular proliferation. Two components of transcriptional regulation are elucidated – transcription factor-mediated regulation and Polycomb Repressive Complex 2 (PRC2)-mediated regulation. Perturbations of these networks yield insight into environmental manipulation of a developmental program. Together, these networks identify novel regulators of vascular development and provide considerable insight into the combinatorial nature of root development at cell type and temporal stage-resolution.

Host: Prof. Nicholas Provart