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CSB Seminar: Prof. J. Todd Blankenship, Director, Molecular and Cellular Biophysics Program, Department of Biological Sciences, University of Denver
January 20, 2017 @ 2:00 pm - 3:00 pm
Departmental Seminar
“Membrane-dependent cell ratcheting and tissue morphogenesis”
Host: Prof. Tony Harris <tony.harris@utoronto.ca>
Abstract:
The control of cell shape is a fundamental property required for epithelial tissue architecture and function. Tensile actomyosin forces have been conventionally thought to drive changes in epithelial cell shape and tissue remodeling. However, here we have examined the coordination of membrane trafficking and cytoskeletal networks to direct progressive changes in cell shape. We show that the AP Patterning system engages a membranous ratchet at the plasma membrane to effect interface contraction during cell intercalation. Our results suggest that endocytic and cytoskeletal forces converge on compartmental behaviors to direct cell shaping events.
Video Conferencing at UTM (DV3138) & UTSc (MW229)