Ashley E. Bruce
Professor
Campus
St. George (downtown)
CSB Appointment
Full
Research Areas
Animal Biology, Cell Biology, Developmental Biology, Genetics / Genomics, Molecular Biology
Education
Ph.D. Harvard University 1997
B.A. Brown University 1990
Primary Undergraduate Department
Cell & Systems Biology
Graduate Programs
Cell & Systems Biology
Developmental Biology
Research Description
How are the complex and varied body plans of animals generated during embryonic development? Coordinated cell shape changes and cell movements, which constitute morphogenesis, generate the structure of tissues and organs of all animals. Concomitant with morphogenesis, is the specification of the germ layers, leading to the assignment of cell fates. Together, morphogenesis and cell fate specification underlie the transformation of a simple cleavage stage embryo into a complex, well-patterned adult, and when they go wrong, profound patterning defects result. Remarkably, the astonishing diversity of animal forms arises from a limited set of cellular processes that are shared by animal species. Thus, by examining these processes in the experimentally tractable zebrafish embryo we can learn about fundamental cellular properties and mechanisms of morphogenesis and tissue patterning that are likely to be widely used throughout animal development.
Contact Information
Office Phone: 416-946-0436
Office: RW 606A
Lab: RW606/RW607
Lab Phone: 416-946-7218
Email
Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada
Recent News
Publications
2023
Two-phase kinetics and cell cortex elastic behavior in Xenopus gastrula cell-cell adhesion
Parent SE, Luu O, Bruce AE, Winklbauer R
2023, Developmental Cell, 10.1016/j.devcel.2023.11.014
2022
Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops.
Talbot CD, Walsh MD, Cutty SJ, Elsayed R, Vlachaki E, Bruce AEE, Wardle FC, Nelson AC
2022, Frontiers in cell and developmental biology, 10, 982477, 36133924
2021
The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium.
Willoughby PM, Allen M, Yu J, Korytnikov R, Chen T, Liu Y, So I, Macpherson N, Mitchell JA, Fernandez-Gonzalez R, Bruce AE
2021, eLife, 10, 33755014
2020
Brachyury in the gastrula of basal vertebrates
Bruce AE, Winklbauer R
2020, Mechanisms of Development, 10.1016/j.mod.2020.103625
Mechanisms of zebrafish epiboly: A current view
Bruce AE, Heisenberg C
2020, , 10.1016/bs.ctdb.2019.07.001
2019
A cargo model of yolk syncytial nuclear migration during zebrafish epiboly.
Fei Z, Bae K, Parent SE, Wan H, Goodwin K, Theisen U, Tanentzapf G, Bruce AEE
2019, Development (Cambridge, England), 146, 30509968
Spatiotemporal characterization of dynamic epithelial filopodia during zebrafish epiboly
Rutherford NE, Wong AH, Bruce AEE
2019, Developmental Dynamics, 10.1002/dvdy.94
2018
Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound Healing.
Hunter MV, Willoughby PM, Bruce AEE, Fernandez-Gonzalez R
2018, Developmental cell, 47, 377-387.e4, 30399336
2017
An Actomyosin-Arf-GEF Negative Feedback Loop for Tissue Elongation under Stress.
West JJ, Zulueta-Coarasa T, Maier JA, Lee DM, Bruce AEE, Fernandez-Gonzalez R, Harris TJC
2017, Current biology : CB, 27, 2260-2270.e5, 28736167
2015
Zebrafish Epiboly: Spreading thin over the yolk
Bruce AE
2015, Developmental dynamics : an official publication of the American Association of Anatomists, 26434660
PAPC mediates self/non-self-distinction during Snail1-dependent tissue separation
Luu O, Damm EW, Parent SE, Barua D, Smith TH, Wen JW, Lepage SE, Nagel M, Ibrahim-Gawel H, Huang Y, Bruce AE, Winklbauer R
2015, The Journal of cell biology, 208, 839-856, 25778923
2014
Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression
Nelson AC, Cutty SJ, Niini M, Stemple DL, Flicek P, Houart C, Bruce A, Wardle FC
2014, BMC biology, 12, 81, 25277163
Dynamin-dependent maintenance of epithelial integrity is essential for zebrafish epiboly
Lepage SE, Bruce AE
2014, Bioarchitecture, 4, 31-4, 24522009
2013
Zebrafish Dynamin is required for maintenance of enveloping layer integrity and the progression of epiboly
Lepage SE, Tada M, Bruce AE
2014, Developmental biology, 385, 52-66, 24161849
2011
Differential regulation of epiboly initiation and progression by zebrafish Eomesodermin A
Du S, Draper BW, Mione M, Moens CB, Bruce A
2012, Developmental biology, 362, 11-23, 22142964
2010
The tight junction component Claudin E is required for zebrafish epiboly
Siddiqui M, Sheikh H, Tran C, Bruce AE
2010, Developmental dynamics : an official publication of the American Association of Anatomists, 239, 715-22, 20014098
Zebrafish epiboly: mechanics and mechanisms
Lepage SE, Bruce AE
2010, The International journal of developmental biology, 54, 1213-28, 20712002
2009
Short- and long-range functions of Goosecoid in zebrafish axis formation are independent of Chordin, Noggin 1 and Follistatin-like 1b
Dixon Fox M, Bruce AE
2009, Development (Cambridge, England), 136, 1675-85, 19369398
2008
Characterization and comparative expression of zebrafish calpain system genes during early development
Lepage SE, Bruce AE
2008, Developmental dynamics : an official publication of the American Association of Anatomists, 237, 819-29, 18265014
2005
Fog1 is required for cardiac looping in zebrafish
Walton RZ, Bruce AE, Olivey HE, Najib K, Johnson V, Earley JU, Ho RK, Svensson EC
2006, Developmental biology, 289, 482-93, 16316643
T-box gene eomesodermin and the homeobox-containing Mix/Bix gene mtx2 regulate epiboly movements in the zebrafish
Bruce AE, Howley C, Dixon Fox M, Ho RK
2005, Developmental dynamics : an official publication of the American Association of Anatomists, 233, 105-14, 15765511