Kenneth Yip

Assistant Professor, Teaching Stream


Campus

St. George (downtown)

CSB Appointment

Full

Research Areas

Cancer, COPA Syndrome, Drug Development, Drug Discovery, Fibrosis

Education

Ph.D., University of Toronto 2006
B.Sc.H., Queen's University 2002

Graduate Programs

Cell and Systems Biology

Research Description

My teaching focus is on evidence-based strategies to improve student success within the biological sciences. Our laboratory interests include cancer, fibrosis, and COPA syndrome, with an emphasis on omics and translational science.


Contact Information

Office Phone: 416-978-5646
Office: 206D
Email

Mailing Address

25 Harbord Street,
Toronto, Ontario,
M5S 3G5

Visit lab’s website


Recent News

Finding Fulfillment in a Fine Lecture with Prof Kenneth Yip

Prof Kenneth Yip learned early in his career that he really enjoys teaching from giving classes as a post-doctoral researcher. “I love to see that…

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Publications

2021

COPA Syndrome (Ala239Pro) Presenting with Isolated Follicular Bronchiolitis in Early Childhood: Case Report.

Psarianos P, Kwan JYY, Dell S, Wee WB, Rey-McIntyre K, Chen H, Dissanayake D, Laxer RM, Shum A, Liu FF, Yip KW
2021, Journal of clinical immunology, 34115278

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2020

Development and Validation of a Risk Model for Breast Cancer-Related Lymphedema.

Kwan JYY, Famiyeh P, Su J, Xu W, Kwan BYM, Jones JM, Chang E, Yip KW, Liu FF
2020, JAMA network open, 3, e2024373, 33175175

MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma.

Bissey PA, Teng M, Law JH, Shi W, Bruce JP, Petit V, Tsao SW, Yip KW, Liu FF
2020, BMC cancer, 20, 597, 32586280

Inflammatory Biomarkers, Hematopoietic Stem Cells, and Symptoms in Breast Cancer Patients Undergoing Adjuvant Radiation Therapy.

Shi W, Misra S, Li M, Su J, Chong LP, McCuske M, Williams J, Xu W, Ghoraie LS, Sutherland DR, Han K, Minden MD, Bratman SV, Yip KW, Liu FF
2020, JNCI cancer spectrum, 4, pkaa037, 33134822

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2019

Targeting metabolic dysregulation for fibrosis therapy.

Zhao X, Kwan JYY, Yip K, Liu PP, Liu FF
2020, Nature reviews. Drug discovery, 19, 57-75, 31548636

Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis.

Zhao X, Psarianos P, Ghoraie LS, Yip K, Goldstein D, Gilbert R, Witterick I, Pang H, Hussain A, Lee JH, Williams J, Bratman SV, Ailles L, Haibe-Kains B, Liu FF
2019, Nature metabolism, 1, 147-157, 32694814

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2018

Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis.

Inoue M, Nakashima R, Enomoto M, Koike Y, Zhao X, Yip K, Huang SH, Waldron JN, Ikura M, Liu FF, Bratman SV
2018, Nature communications, 9, 5116, 30504805

hsa‑miR‑24 suppresses metastasis in nasopharyngeal carcinoma by regulating the c‑Myc/epithelial‑mesenchymal transition axis.

Su B, Xu T, Bruce JP, Yip KW, Zhang N, Huang Z, Zhang G, Liu FF, Liang J, Yang H, Claret FX
2018, Oncology reports, 40, 2536-2546, 30226609

Dysregulation of the MiR-449b target TGFBI alters the TGFβ pathway to induce cisplatin resistance in nasopharyngeal carcinoma.

Bissey PA, Law JH, Bruce JP, Shi W, Renoult A, Chua MLK, Yip KW, Liu FF
2018, Oncogenesis, 7, 40, 29795279

Radiomic Biomarkers to Refine Risk Models for Distant Metastasis in HPV-related Oropharyngeal Carcinoma.

Kwan JYY, Su J, Huang SH, Ghoraie LS, Xu W, Chan B, Yip KW, Giuliani M, Bayley A, Kim J, Hope AJ, Ringash J, Cho J, McNiven A, Hansen A, Goldstein D, de Almeida JR, Aerts HJ, Waldron JN, Haibe-Kains B, O\'Sullivan B, Bratman SV, Liu FF
2018, International journal of radiation oncology, biology, physics, 102, 1107-1116, 29506884

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2016

Imaging the Modulation of Adenoviral Kinetics and Biodistribution for Cancer Gene Therapy.

Mocanu JD, Yip KW, Alajez NM, Shi W, Li JH, Lunt SJ, Moriyama EH, Wilson BC, Milosevic M, Lo KW, van Rooijen NV, Busson P, Bastianutto C, Liu FF
2007, Molecular therapy : the journal of the American Society of Gene Therapy, 15, 921-929, 28182894

HPV Associated Head and Neck Cancer.

Spence T, Bruce J, Yip KW, Liu FF
2016, Cancers, 8, 27527216

MicroRNAs in extracellular vesicles: potential cancer biomarkers.

Kinoshita T, Yip KW, Spence T, Liu FF
2017, Journal of human genetics, 62, 67-74, 27383658

Human Papillomavirus Genotype Association With Survival in Head and Neck Squamous Cell Carcinoma.

Bratman SV, Bruce JP, O\'Sullivan B, Pugh TJ, Xu W, Yip KW, Liu FF
2016, JAMA oncology, 2, 823-6, 27010835

MiR-449a promotes breast cancer progression by targeting CRIP2.

Shi W, Bruce J, Lee M, Yue S, Rowe M, Pintilie M, Kogo R, Bissey PA, Fyles A, Yip KW, Liu FF
2016, Oncotarget, 7, 18906-18, 26934316

MicroRNAs in nasopharyngeal carcinoma.

Spence T, Bruce J, Yip KW, Liu FF
2016, Chinese clinical oncology, 5, 17, 27121877

The complexity of microRNAs in human cancer.

Kwan JY, Psarianos P, Bruce JP, Yip KW, Liu FF
2016, Journal of radiation research, i106-i111, 26983984

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2015

Nasopharyngeal Cancer: Molecular Landscape.

Bruce JP, Yip K, Bratman SV, Ito E, Liu FF
2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33, 3346-55, 26351340

The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer.

Kogo R, How C, Chaudary N, Bruce J, Shi W, Hill RP, Zahedi P, Yip KW, Liu FF
2015, Oncotarget, 6, 1090-100, 25473903

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2014

Dissecting the leukemogenic potency of BCLxl.

Saurabh K, Scherzer MT, Song A, Yip KW, Reed JC, Li C, Beverly LJ
, Journal of leukemia (Los Angeles, Calif.), 2, 158, 26636115

Pre-clinical characterization of Dacomitinib (PF-00299804), an irreversible pan-ErbB inhibitor, combined with ionizing radiation for head and neck squamous cell carcinoma.

Williams JP, Kim I, Ito E, Shi W, Yue S, Siu LL, Waldron J, O\'Sullivan B, Yip KW, Liu FF
2014, PloS one, 9, e98557, 24853121

A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase.

Yip KW, Zhang Z, Sakemura-Nakatsugawa N, Huang JW, Vu NM, Chiang YK, Lin CL, Kwan JY, Yue S, Jitkova Y, To T, Zahedi P, Pai EF, Schimmer AD, Lovell JF, Sessler JL, Liu FF
2014, PloS one, 9, e89889, 24587102

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2011

Uroporphyrinogen decarboxylase: optimizing radiotherapy for head and neck cancer.

Ito E, Yip KW, Liu FF
2011, Future oncology (London, England), 7, 595-7, 21568673

A high-content screening (HCS) assay for the identification of chemical inducers of PML oncogenic domains (PODs).

Yip KW, Cuddy M, Pinilla C, Giulanotti M, Heynen-Genel S, Matsuzawa S, Reed JC
2011, Journal of biomolecular screening, 16, 251-8, 21233309

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2010

ARTS and Siah collaborate in a pathway for XIAP degradation.

Garrison JB, Correa RG, Gerlic M, Yip KW, Krieg A, Tamble CM, Shi R, Welsh K, Duggineni S, Huang Z, Ren K, Du C, Reed JC
2011, Molecular cell, 41, 107-16, 21185211

Development and validation of an RNAi screen for ABT-737 sensitizers

Reed J
2010, International Journal of High Throughput Screening, 10.2147/IJHTS.S12352

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2009

Versatile assays for high throughput screening for activators or inhibitors of intracellular proteases and their cellular regulators.

Hayashi H, Cuddy M, Shu VC, Yip KW, Madiraju C, Diaz P, Matsuyama T, Kaibara M, Taniyama K, Vasile S, Sergienko E, Reed JC
2009, PloS one, 4, e7655, 19876397

Potential use of cetrimonium bromide as an apoptosis-promoting anticancer agent for head and neck cancer.

Ito E, Yip KW, Katz D, Fonseca SB, Hedley DW, Chow S, Xu GW, Wood TE, Bastianutto C, Schimmer AD, Kelley SO, Liu FF
2009, Molecular pharmacology, 76, 969-83, 19654225

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2008

Bcl-2 family proteins and cancer.

Yip KW, Reed JC
2008, Oncogene, 27, 6398-406, 18955968

A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors.

Yip KW, Godoi PH, Zhai D, Garcia X, Cellitti JF, Cuddy M, Gerlic M, Chen Y, Satterthwait A, Vasile S, Sergienko E, Reed JC
2008, Journal of biomolecular screening, 13, 665-73, 18626112

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2007

Imaging and modulating antisense microdistribution in solid human xenograft tumor models.

Mocanu JD, Yip KW, Skliarenko J, Shi W, Busson P, Lo KW, Bastianutto C, Liu FF
2007, Clinical cancer research : an official journal of the American Association for Cancer Research, 13, 5935-41, 17908990

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2006

Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer.

Yip KW, Shi W, Pintilie M, Martin JD, Mocanu JD, Wong D, MacMillan C, Gullane P, O\'Sullivan B, Bastianutto C, Liu FF
2006, Clinical cancer research : an official journal of the American Association for Cancer Research, 12, 5726-32, 17020977

Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen.

Yip KW, Mao X, Au PY, Hedley DW, Chow S, Dalili S, Mocanu JD, Bastianutto C, Schimmer A, Liu FF
2006, Clinical cancer research : an official journal of the American Association for Cancer Research, 12, 5557-69, 17000693

Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent.

Yip KW, Ito E, Mao X, Au PY, Hedley DW, Mocanu JD, Bastianutto C, Schimmer A, Liu FF
2006, Molecular cancer therapeutics, 5, 2234-40, 16985057

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2005

Combination bcl-2 antisense and radiation therapy for nasopharyngeal cancer.

Yip KW, Mocanu JD, Au PY, Sleep GT, Huang D, Busson P, Yeh WC, Gilbert R, O\'Sullivan B, Gullane P, Bastianutto C, Liu FF
2005, Clinical cancer research : an official journal of the American Association for Cancer Research, 11, 8131-44, 16299246

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2004

Combined in vivo bioluminescence and fluorescence imaging for cancer gene therapy.

Mocanu JD, Moriyama EH, Chia MC, Li JH, Yip KW, Huang DP, Bastianutto C, Wilson BC, Liu FF
2004, Molecular imaging, 3, 352-5, 15802052

Potential utility of BimS as a novel apoptotic therapeutic molecule.

Yip KW, Li A, Li JH, Shi W, Chia MC, Rashid SA, Mocanu JD, Louie AV, Sanchez O, Huang D, Busson P, Yeh WC, Gilbert R, O\'sullivan B, Gullane P, Liu FF
2004, Molecular therapy : the journal of the American Society of Gene Therapy, 10, 533-44, 15336653

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