Kenneth Yip
Assistant Professor, Teaching Stream
Campus
St. George (downtown)
CSB Appointment
Teaching
Research Areas
Science Pedagogy
Education
Ph.D., University of Toronto 2006
B.Sc.H., Queen's University 2002
Graduate Programs
Cell and Systems Biology
Research Description
My teaching focus is on the use of classroom learning to improve experiential learning, and experiential learning to improve classroom learning. This focus creates a cycle between the two, which continually strengthens and expands student knowledge. My scientific research interests include cancer, fibrosis, and COPA syndrome, with an emphasis on omics, experimental therapeutics, and translational science.
Contact Information
Office Phone: 416-978-5646
Office: 206D
Email
Mailing Address
25 Harbord Street,
Toronto, Ontario,
M5S 3G5
Recent News
Publications
2022
Editorial: Hallmark of cancer: Resisting cell death.
Zhu Y, Yang R, Law JH, Khan M, Yip KW, Sun Q
2022, Frontiers in oncology, 12, 1069947, 36419903
CD8+ Tumor-Infiltrating Lymphocyte Abundance is a Positive Prognostic Indicator in Nasopharyngeal Cancer.
Shi W, Fijardo M, Bruce JP, Su J, Xu W, Bell R, Bissey PA, Hui AB, Waldron J, Pugh TJ, Yip KW, Liu FF
2022, Clinical cancer research : an official journal of the American Association for Cancer Research, 36129469
2021
COPA Syndrome (Ala239Pro) Presenting with Isolated Follicular Bronchiolitis in Early Childhood: Case Report.
Psarianos P, Kwan JYY, Dell S, Wee WB, Rey-McIntyre K, Chen H, Dissanayake D, Laxer RM, Shum A, Liu FF, Yip KW
2021, Journal of clinical immunology, 34115278
2020
Development and Validation of a Risk Model for Breast Cancer-Related Lymphedema.
Kwan JYY, Famiyeh P, Su J, Xu W, Kwan BYM, Jones JM, Chang E, Yip KW, Liu FF
2020, JAMA network open, 3, e2024373, 33175175
MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma.
Bissey PA, Teng M, Law JH, Shi W, Bruce JP, Petit V, Tsao SW, Yip KW, Liu FF
2020, BMC cancer, 20, 597, 32586280
Inflammatory Biomarkers, Hematopoietic Stem Cells, and Symptoms in Breast Cancer Patients Undergoing Adjuvant Radiation Therapy.
Shi W, Misra S, Li M, Su J, Chong LP, McCuske M, Williams J, Xu W, Ghoraie LS, Sutherland DR, Han K, Minden MD, Bratman SV, Yip KW, Liu FF
2020, JNCI cancer spectrum, 4, pkaa037, 33134822
2019
Targeting metabolic dysregulation for fibrosis therapy.
Zhao X, Kwan JYY, Yip K, Liu PP, Liu FF
2020, Nature reviews. Drug discovery, 19, 57-75, 31548636
Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis.
Zhao X, Psarianos P, Ghoraie LS, Yip K, Goldstein D, Gilbert R, Witterick I, Pang H, Hussain A, Lee JH, Williams J, Bratman SV, Ailles L, Haibe-Kains B, Liu FF
2019, Nature metabolism, 1, 147-157, 32694814
2018
Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis.
Inoue M, Nakashima R, Enomoto M, Koike Y, Zhao X, Yip K, Huang SH, Waldron JN, Ikura M, Liu FF, Bratman SV
2018, Nature communications, 9, 5116, 30504805
hsa‑miR‑24 suppresses metastasis in nasopharyngeal carcinoma by regulating the c‑Myc/epithelial‑mesenchymal transition axis.
Su B, Xu T, Bruce JP, Yip KW, Zhang N, Huang Z, Zhang G, Liu FF, Liang J, Yang H, Claret FX
2018, Oncology reports, 40, 2536-2546, 30226609
Dysregulation of the MiR-449b target TGFBI alters the TGFβ pathway to induce cisplatin resistance in nasopharyngeal carcinoma.
Bissey PA, Law JH, Bruce JP, Shi W, Renoult A, Chua MLK, Yip KW, Liu FF
2018, Oncogenesis, 7, 40, 29795279
Radiomic Biomarkers to Refine Risk Models for Distant Metastasis in HPV-related Oropharyngeal Carcinoma.
Kwan JYY, Su J, Huang SH, Ghoraie LS, Xu W, Chan B, Yip KW, Giuliani M, Bayley A, Kim J, Hope AJ, Ringash J, Cho J, McNiven A, Hansen A, Goldstein D, de Almeida JR, Aerts HJ, Waldron JN, Haibe-Kains B, O\'Sullivan B, Bratman SV, Liu FF
2018, International journal of radiation oncology, biology, physics, 102, 1107-1116, 29506884
2016
Imaging the Modulation of Adenoviral Kinetics and Biodistribution for Cancer Gene Therapy.
Mocanu JD, Yip KW, Alajez NM, Shi W, Li JH, Lunt SJ, Moriyama EH, Wilson BC, Milosevic M, Lo KW, van Rooijen NV, Busson P, Bastianutto C, Liu FF
2007, Molecular therapy : the journal of the American Society of Gene Therapy, 15, 921-929, 28182894
MicroRNAs in extracellular vesicles: potential cancer biomarkers.
Kinoshita T, Yip KW, Spence T, Liu FF
2017, Journal of human genetics, 62, 67-74, 27383658
Human Papillomavirus Genotype Association With Survival in Head and Neck Squamous Cell Carcinoma.
Bratman SV, Bruce JP, O\'Sullivan B, Pugh TJ, Xu W, Yip KW, Liu FF
2016, JAMA oncology, 2, 823-6, 27010835
MiR-449a promotes breast cancer progression by targeting CRIP2.
Shi W, Bruce J, Lee M, Yue S, Rowe M, Pintilie M, Kogo R, Bissey PA, Fyles A, Yip KW, Liu FF
2016, Oncotarget, 7, 18906-18, 26934316
MicroRNAs in nasopharyngeal carcinoma.
Spence T, Bruce J, Yip KW, Liu FF
2016, Chinese clinical oncology, 5, 17, 27121877
The complexity of microRNAs in human cancer.
Kwan JY, Psarianos P, Bruce JP, Yip KW, Liu FF
2016, Journal of radiation research, i106-i111, 26983984
2015
Nasopharyngeal Cancer: Molecular Landscape.
Bruce JP, Yip K, Bratman SV, Ito E, Liu FF
2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33, 3346-55, 26351340
The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer.
Kogo R, How C, Chaudary N, Bruce J, Shi W, Hill RP, Zahedi P, Yip KW, Liu FF
2015, Oncotarget, 6, 1090-100, 25473903
2014
Dissecting the leukemogenic potency of BCLxl.
Saurabh K, Scherzer MT, Song A, Yip KW, Reed JC, Li C, Beverly LJ
, Journal of leukemia (Los Angeles, Calif.), 2, 158, 26636115
Pre-clinical characterization of Dacomitinib (PF-00299804), an irreversible pan-ErbB inhibitor, combined with ionizing radiation for head and neck squamous cell carcinoma.
Williams JP, Kim I, Ito E, Shi W, Yue S, Siu LL, Waldron J, O\'Sullivan B, Yip KW, Liu FF
2014, PloS one, 9, e98557, 24853121
A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase.
Yip KW, Zhang Z, Sakemura-Nakatsugawa N, Huang JW, Vu NM, Chiang YK, Lin CL, Kwan JY, Yue S, Jitkova Y, To T, Zahedi P, Pai EF, Schimmer AD, Lovell JF, Sessler JL, Liu FF
2014, PloS one, 9, e89889, 24587102
2011
Uroporphyrinogen decarboxylase: optimizing radiotherapy for head and neck cancer.
Ito E, Yip KW, Liu FF
2011, Future oncology (London, England), 7, 595-7, 21568673
A high-content screening (HCS) assay for the identification of chemical inducers of PML oncogenic domains (PODs).
Yip KW, Cuddy M, Pinilla C, Giulanotti M, Heynen-Genel S, Matsuzawa S, Reed JC
2011, Journal of biomolecular screening, 16, 251-8, 21233309
2010
ARTS and Siah collaborate in a pathway for XIAP degradation.
Garrison JB, Correa RG, Gerlic M, Yip KW, Krieg A, Tamble CM, Shi R, Welsh K, Duggineni S, Huang Z, Ren K, Du C, Reed JC
2011, Molecular cell, 41, 107-16, 21185211
Development and validation of an RNAi screen for ABT-737 sensitizers
Reed J
2010, International Journal of High Throughput Screening, 10.2147/IJHTS.S12352
2009
Versatile assays for high throughput screening for activators or inhibitors of intracellular proteases and their cellular regulators.
Hayashi H, Cuddy M, Shu VC, Yip KW, Madiraju C, Diaz P, Matsuyama T, Kaibara M, Taniyama K, Vasile S, Sergienko E, Reed JC
2009, PloS one, 4, e7655, 19876397
Potential use of cetrimonium bromide as an apoptosis-promoting anticancer agent for head and neck cancer.
Ito E, Yip KW, Katz D, Fonseca SB, Hedley DW, Chow S, Xu GW, Wood TE, Bastianutto C, Schimmer AD, Kelley SO, Liu FF
2009, Molecular pharmacology, 76, 969-83, 19654225
2008
A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors.
Yip KW, Godoi PH, Zhai D, Garcia X, Cellitti JF, Cuddy M, Gerlic M, Chen Y, Satterthwait A, Vasile S, Sergienko E, Reed JC
2008, Journal of biomolecular screening, 13, 665-73, 18626112
2007
Imaging and modulating antisense microdistribution in solid human xenograft tumor models.
Mocanu JD, Yip KW, Skliarenko J, Shi W, Busson P, Lo KW, Bastianutto C, Liu FF
2007, Clinical cancer research : an official journal of the American Association for Cancer Research, 13, 5935-41, 17908990
2006
Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer.
Yip KW, Shi W, Pintilie M, Martin JD, Mocanu JD, Wong D, MacMillan C, Gullane P, O\'Sullivan B, Bastianutto C, Liu FF
2006, Clinical cancer research : an official journal of the American Association for Cancer Research, 12, 5726-32, 17020977
Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen.
Yip KW, Mao X, Au PY, Hedley DW, Chow S, Dalili S, Mocanu JD, Bastianutto C, Schimmer A, Liu FF
2006, Clinical cancer research : an official journal of the American Association for Cancer Research, 12, 5557-69, 17000693
Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent.
Yip KW, Ito E, Mao X, Au PY, Hedley DW, Mocanu JD, Bastianutto C, Schimmer A, Liu FF
2006, Molecular cancer therapeutics, 5, 2234-40, 16985057
2005
Combination bcl-2 antisense and radiation therapy for nasopharyngeal cancer.
Yip KW, Mocanu JD, Au PY, Sleep GT, Huang D, Busson P, Yeh WC, Gilbert R, O\'Sullivan B, Gullane P, Bastianutto C, Liu FF
2005, Clinical cancer research : an official journal of the American Association for Cancer Research, 11, 8131-44, 16299246
2004
Combined in vivo bioluminescence and fluorescence imaging for cancer gene therapy.
Mocanu JD, Moriyama EH, Chia MC, Li JH, Yip KW, Huang DP, Bastianutto C, Wilson BC, Liu FF
2004, Molecular imaging, 3, 352-5, 15802052
Potential utility of BimS as a novel apoptotic therapeutic molecule.
Yip KW, Li A, Li JH, Shi W, Chia MC, Rashid SA, Mocanu JD, Louie AV, Sanchez O, Huang D, Busson P, Yeh WC, Gilbert R, O\'sullivan B, Gullane P, Liu FF
2004, Molecular therapy : the journal of the American Society of Gene Therapy, 10, 533-44, 15336653