Maithe Arruda-Carvalho
Assistant Professor
Campus
UTSC
CSB Appointment
Full
Research Areas
Animal Biology, Cell Biology, Neurobiology, Systems Biology
Education
PhD University of Toronto 2012,
MSc Federal University of Rio de Janeiro 2007,
BSc Federal University of Rio de Janeiro 2004
Primary Undergraduate Department
Psychology
Graduate Programs
Psychology
Cell & Systems Biology
Neuroscience
Research Description
Our lab uses a systems level approach to explore the relationship between the maturation of sensitive brain circuits, the emergence of complex behaviour, and stress sensitivity in mice.
Contact Information
Office Phone: 416-208-8130
Office: SW533
Lab: SW332
Email
Mailing Address
1265 Military Trail
Science Wing, Room SW533
Toronto, ON M1C 1A4
Canada
Publications
Arruda-Carvalho M, Clem RL. Prefrontal-amygdala fear networks come into focus.
Front Syst Neurosci 9:145, 2015.
PMID:26578902
Arruda-Carvalho M, Clem RL. Pathway-selective adjustment of prefrontal-amygdala transmission during fear encoding.
Journal of Neuroscience 34(47):15601-9, 2014
PMID:25411488
Arruda-Carvalho M, Akers KG, Guskjolen A, Sakaguchi M, Josselyn SA, Frankland PW. Post-training ablation of adult-generated olfactory granule cells degrades odor-reward memories.
Journal of Neuroscience 34(47):15793-803, 2014
PMID:25411506
Arruda-Carvalho M, Restivo L, Guskjolen A, Epp JR, Elgersma Y, Josselyn SA, Frankland PW. Conditional Deletion of α-CaMKII Impairs Integration of Adult-Generated Granule Cells into Dentate Gyrus Circuits and Hippocampus-Dependent Learning.
Journal of Neuroscience 34(36): 11919-28 (2014)
PMID:25186740
Akers KG, Arruda-Carvalho M, Josselyn SA, Frankland PW. Ontogeny of contextual fear memory formation, specificity, and persistence in mice.
Learning & Memory. 19(12):598-604 (2012).
PMID:23161449
Gu Y, Arruda-Carvalho M, Wang J, Janoschka S, Josselyn SA, Frankland PW, Ge S. Optical controlling reveals time-dependent roles for adult-born dentate granule cells.
Nature Neuroscience 15(12):1700-6. (2012)
PMID:23143513
Arruda-Carvalho M, Sakaguchi M, Akers KG, Josselyn SA, Frankland PW. Posttraining ablation of adult-generated neurons degrades previously acquired memories.
Journal of Neuroscience 31(42):15113-27(2011)
Comment in Nature 478 (7370) 431.
PMID:22016545
Sakaguchi M, Arruda-Carvalho M, Kang NH, Imaizumi Y, Poirier F, Okano H, Frankland PW. Impaired spatial and contextual memory formation in galectin-1 deficient mice.
Molecular Brain. 4(1):33 (2011)
PMID:21884595
Leslie AT, Akers KG, Krakowski AD, Stone SSD, Sakaguchi M, Arruda-Carvalho M, Frankland PW. Impact of early adverse experience on complexity of adult-generated neurons.
Translational Psychiatry 1, e35 (2011)
PMID:22832609
Ribas VT, Arruda-Carvalho M, Linden R, Chiarini LB. Early c-Jun N-terminal kinase-dependent phosphorylation of activating transcription factor-2 is associated with degeneration of retinal ganglion cells.
Neuroscience 180:64-74 (2011)
PMID:21300140
Akers KG, Sakaguchi M, Arruda-Carvalho M. Functional contribution of adult-generated olfactory bulb interneurons: odor discrimination versus odor memory.
Journal of Neuroscience 30(13):4523-5 (2010)
PMID:20357101
Frankland PW, Sakaguchi M, Arruda-Carvalho M. Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
Molecular Brain. 1(1):5 (2008)
PMID:18803858
Arruda-Carvalho M, Njaine B, Silveira MS, Linden R, Chiarini LB. Hop/STI1 modulates retinal proliferation and cell death independent of PrPC. Biochem Biophys Res Commun. 361(2):474-80 (2007)
PMID:17651690