Professor Michael Phillips

Michael Phillips

Assistant Professor


Campus

UTM

CSB Appointment

Full

Research Areas

Cell Biology, Chemical Biology, Metabolomics, Molecular Biology, Plant Biology, Quantitative Biology /Modelling, Systems Biology

Education

Ph.D. Washington State University 2000
BSc California State University at Humboldt 1994

Primary Undergraduate Department

Biology, UTM

Graduate Programs

Cell & Systems Biology

Research Description

My research focuses on the control of flux in plant metabolic networks and the adaptive responses of the plant metabolome to stress at the interface of primary and secondary metabolism.


Mailing Address

Department of Biology
University of Toronto
3359 Mississauga Road
Mississauga, ON L5L 1C6
Canada

Visit lab’s website


Publications

2021

Production of plant bioactive triterpenoid saponins: from metabolites to genes and back

da Silva Magedans YV, Phillips MA, Fett-Neto AG
2021, Phytochemistry Reviews, 10.1007/s11101-020-09722-4

Structural diversity and biosynthesis of plant derived p-menthane monoterpenes

Bergman ME, Phillips MA
2021, Phytochemistry Reviews, 10.1007/s11101-020-09726-0

Isotope ratio-based quantification of carbon assimilation highlights the role of plastidial isoprenoid precursor availability in photosynthesis

Bergman ME, González-Cabanelas D, Wright LP, Walker BJ, Phillips MA
2021, Plant Methods, 10.1186/s13007-021-00731-8

Cytosolic geraniol and citronellol biosynthesis require a Nudix hydrolase in rose scented geranium (Pelargonium graveolens)

Bergman ME, Bhardwaj M, Phillips MA
2021, The Plant Journal, 10.1111/tpj.15304

Negative regulation of plastidial isoprenoid pathway by herbivore-induced β-cyclocitral in Arabidopsis thaliana

Mitra S, Estrada-Tejedor R, Volke DC, Phillips MA, Gershenzon J, Wright LP
2021, Proceedings of the National Academy of Sciences, 10.1073/pnas.2008747118

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2020

Distinct metabolic pathways drive monoterpenoid biosynthesis in a natural population of Pelargonium graveolens.

Bergman ME, Chávez Á, Ferrer A, Phillips MA
2020, Journal of experimental botany, 71, 258-271, 31504760

Genetic dissection of climacteric fruit ripening in a melon population segregating for ripening behavior

Pereira L, Santo Domingo M, Ruggieri V, Argyris J, Phillips MA, Zhao G, Lian Q, Xu Y, He Y, Huang S, Pujol M, Garcia-Mas J
2020, Horticulture Research, 10.1038/s41438-020-00411-z

A Late Miocene to Late Pleistocene Reconstruction of Precipitation Isotopes and Climate From Hydrated Volcanic Glass Shards and Biomarkers in Central Alaska and Yukon

Otiniano GA, Porter TJ, Benowitz JA, Bindeman IN, Froese DG, Jensen BJL, Davies LJ, Phillips MA
2020, Paleoceanography and Paleoclimatology, 10.1029/2019PA003791

Cellular and Subcellular Compartmentation of the 2C-Methyl-D-Erythritol 4-Phosphate Pathway in the Madagascar Periwinkle

Guirimand G, Guihur A, Perello C, Phillips M, Mahroug S, Oudin A, Dugé de Bernonville T, Besseau S, Lanoue A, Giglioli-Guivarc’h N, Papon N, St-Pierre B, Rodríguez-Concepcíon M, Burlat V, Courdavault V
2020, Plants, 10.3390/plants9040462

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2019

Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action.

Bergman ME, Davis B, Phillips MA
2019, Molecules (Basel, Switzerland), 24, 31683764

The plastidial metabolite 2-C-methyl-D-erythritol-2,4-cyclodiphosphate modulates defence responses against aphids

Onkokesung N, Reichelt M, Wright LP, Phillips MA, Gershenzon J, Dicke M
2019, Plant, Cell & Environment, 10.1111/pce.13538

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2018

Nerolidol production in agroinfiltrated tobacco: Impact of protein stability and membrane targeting of strawberry (Fragraria ananassa) NEROLIDOL SYNTHASE1

Andrade P, Manzano D, Ramirez-Estrada K, Caudepon D, Arro M, Ferrer A, Phillips MA
2018, Plant Science, 10.1016/j.plantsci.2017.11.013

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2017

Non-invasive quantification of ethylene in attached fruit headspace at 1 p.p.b. by gas chromatography-mass spectrometry

Pereira L, Pujol M, Garcia-Mas J, Phillips MA
2017, The Plant Journal, 10.1111/tpj.13545

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2016

Differential Subplastidial Localization and Turnover of Enzymes Involved in Isoprenoid Biosynthesis in Chloroplasts.

Perello C, Llamas E, Burlat V, Ortiz-Alcaide M, Phillips MA, Pulido P, Rodriguez-Concepcion M
2016, PloS one, 11, e0150539, 26919668

Differential Subplastidial Localization and Turnover of Enzymes Involved in Isoprenoid Biosynthesis in Chloroplasts.

Perello C, Llamas E, Burlat V, Ortiz-Alcaide M, Phillips MA, Pulido P, Rodriguez-Concepcion M
2016, PloS one, 11, e0150539, 26919668

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2015

Comparative transcriptional profiling analysis of developing melon (Cucumis melo L.) fruit from climacteric and non-climacteric varieties.

Saladié M, Cañizares J, Phillips MA, Rodriguez-Concepcion M, Larrigaudière C, Gibon Y, Stitt M, Lunn JE, Garcia-Mas J
2015, BMC genomics, 16, 440, 26054931

The diversion of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate from the 2-C-methyl-D-erythritol 4-phosphate pathway to hemiterpene glycosides mediates stress responses in Arabidopsis thaliana.

González-Cabanelas D, Wright LP, Paetz C, Onkokesung N, Gershenzon J, Rodríguez-Concepción M, Phillips MA
2015, The Plant journal : for cell and molecular biology, 82, 122-37, 25704332

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2014

The 2-C-methylerythritol 4-phosphate pathway in melon is regulated by specialized isoforms for the first and last steps.

Saladié M, Wright LP, Garcia-Mas J, Rodriguez-Concepcion M, Phillips MA
2014, Journal of experimental botany, 65, 5077-92, 25013119

Deoxyxylulose 5-Phosphate Synthase Controls Flux through the Methylerythritol 4-Phosphate Pathway in Arabidopsis.

Wright LP, Rohwer JM, Ghirardo A, Hammerbacher A, Ortiz-Alcaide M, Raguschke B, Schnitzler JP, Gershenzon J, Phillips MA
2014, Plant physiology, 165, 1488-1504, 24987018

Measuring the activity of 1-deoxy-D-xylulose 5-phosphate synthase, the first enzyme in the MEP pathway, in plant extracts.

Wright LP, Phillips MA
2014, Methods in molecular biology (Clifton, N.J.), 1153, 9-20, 24777787

Influence of medium and elicitors on the production of cocaine, amino acids and phytohormones by Erythroxylum coca calli

Docimo T, Davis AJ, Luck K, Fellenberg C, Reichelt M, Phillips M, Gershenzon J, D’Auria JC
2014, Plant Cell, Tissue and Organ Culture (PCTOC), 10.1007/s11240-014-0660-8

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2013

Arabidopsis J-protein J20 delivers the first enzyme of the plastidial isoprenoid pathway to protein quality control.

Pulido P, Toledo-Ortiz G, Phillips MA, Wright LP, Rodríguez-Concepción M
2013, The Plant cell, 25, 4183-94, 24104567

Arabidopsis J-protein J20 delivers the first enzyme of the plastidial isoprenoid pathway to protein quality control.

Pulido P, Toledo-Ortiz G, Phillips MA, Wright LP, Rodríguez-Concepción M
2013, The Plant cell, 25, 4183-94, 24104567

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2012

Triple subcellular targeting of isopentenyl diphosphate isomerases encoded by a single gene.

Guirimand G, Guihur A, Phillips MA, Oudin A, Glévarec G, Mahroug S, Melin C, Papon N, Clastre M, Giglioli-Guivarc\'h N, St-Pierre B, Rodríguez-Concepción M, Burlat V, Courdavault V
2012, Plant signaling & behavior, 7, 1495-7, 22951398

A single gene encodes isopentenyl diphosphate isomerase isoforms targeted to plastids, mitochondria and peroxisomes in Catharanthus roseus.

Guirimand G, Guihur A, Phillips MA, Oudin A, Glévarec G, Melin C, Papon N, Clastre M, St-Pierre B, Rodríguez-Concepción M, Burlat V, Courdavault V
2012, Plant molecular biology, 79, 443-59, 22638903

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2009

Pleiotropic regulatory locus 1 (PRL1) integrates the regulation of sugar responses with isoprenoid metabolism in Arabidopsis.

Flores-Pérez U, Pérez-Gil J, Closa M, Wright LP, Botella-Pavía P, Phillips MA, Ferrer A, Gershenzon J, Rodríguez-Concepción M
2010, Molecular plant, 3, 101-12, 20008452

Evaluation of Candidate Reference Genes for Real-Time Quantitative PCR of Plant Samples Using Purified cDNA as Template.

Phillips MA, D\'Auria JC, Luck K, Gershenzon J
2009, Plant molecular biology reporter, 27, 407-416, 24489433

Quantitative iTRAQ proteome and comparative transcriptome analysis of elicitor-induced Norway spruce (Picea abies) cells reveals elements of calcium signaling in the early conifer defense response.

Lippert DN, Ralph SG, Phillips M, White R, Smith D, Hardie D, Gershenzon J, Ritland K, Borchers CH, Bohlmann J
2009, Proteomics, 9, 350-67, 19105170

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2008

The plastidial MEP pathway: unified nomenclature and resources.

Phillips MA, León P, Boronat A, Rodríguez-Concepción M
2008, Trends in plant science, 13, 619-23, 18948055

The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis.

Phillips MA, D\'Auria JC, Gershenzon J, Pichersky E
2008, The Plant cell, 20, 677-96, 18319397

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2007

Functional identification and differential expression of 1-deoxy-D-xylulose 5-phosphate synthase in induced terpenoid resin formation of Norway spruce (Picea abies).

Phillips MA, Walter MH, Ralph SG, Dabrowska P, Luck K, Urós EM, Boland W, Strack D, Rodríguez-Concepción M, Bohlmann J, Gershenzon J
2007, Plant molecular biology, 65, 243-57, 17687625

Functional identification and differential expression of 1-deoxy-D-xylulose 5-phosphate synthase in induced terpenoid resin formation of Norway spruce (Picea abies).

Phillips MA, Walter MH, Ralph SG, Dabrowska P, Luck K, Urós EM, Boland W, Strack D, Rodríguez-Concepción M, Bohlmann J, Gershenzon J
2007, Plant molecular biology, 65, 243-57, 17687625

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2006

Molecular Regulation of Induced Terpenoid Biosynthesis in Conifers

Phillips MA, Bohlmann J, Gershenzon J
2006, Phytochemistry Reviews, 10.1007/s11101-006-0001-6

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2004

Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol.

Besumbes O, Sauret-Güeto S, Phillips MA, Imperial S, Rodríguez-Concepción M, Boronat A
2004, Biotechnology and bioengineering, 88, 168-75, 15449291

Regulation of carotenoid biosynthesis in plants: evidence for a key role of hydroxymethylbutenyl diphosphate reductase in controlling the supply of plastidial isoprenoid precursors.

Botella-Pavía P, Besumbes O, Phillips MA, Carretero-Paulet L, Boronat A, Rodríguez-Concepción M
2004, The Plant journal : for cell and molecular biology, 40, 188-99, 15447646

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2003

Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development.

Rodríguez-Concepción M, Forés O, Martinez-García JF, González V, Phillips MA, Ferrer A, Boronat A
2004, The Plant cell, 16, 144-56, 14660801

cDNA isolation, functional expression, and characterization of (+)-alpha-pinene synthase and (-)-alpha-pinene synthase from loblolly pine (Pinus taeda): stereocontrol in pinene biosynthesis.

Phillips MA, Wildung MR, Williams DC, Hyatt DC, Croteau R
2003, Archives of biochemistry and biophysics, 411, 267-76, 12623076

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1999

Monoterpene synthases of loblolly pine (Pinus taeda) produce pinene isomers and enantiomers.

Phillips MA, Savage TJ, Croteau R
1999, Archives of biochemistry and biophysics, 372, 197-204, 10562434

cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis).

Bohlmann J, Phillips M, Ramachandiran V, Katoh S, Croteau R
1999, Archives of biochemistry and biophysics, 368, 232-43, 10441373

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