Mounir G. AbouHaidar
Professor
Campus
St. George (downtown)
CSB Appointment
Full
Research Areas
Biotechnology, Genetics / Genomics, Microbiology, Molecular Biology
Education
Ph.D. D.S. University of Strasbourg, France 1973 & 1976
M.Sc. University of Strasbourg, France 1971
Primary Undergraduate Department
Cell & Systems Biology
Graduate Programs
Cell & Systems Biology
Developmental Biology
Research Description
Research interests lie in the area of the molecular biology of plant and human viruses. Development of “”transgenic”” plants resistant to viruses: mechanisms of resistance. Genome organization, self-splicing (Ribozyme) and replication strategies of some viruses and their satellite RNAs. Development of recombinant vaccines produced in plants. Plant antiviral proteins for gene therapy of AIDS. Molecular mechanisms involved in the translation in Pro- and Eukaryotes: alternative modes of initiation of translation. Development of vaccines (e.g. HCV).
Contact Information
Office Phone: 416-978-5615
Office: ESC4057
Lab: ESC4054
Lab Phone: 416-978-5594
Email
Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Willcocks St.
Toronto, ON M5S 3B2
Canada
Recent News
Publications
2023
Polyvalent immunization elicits a synergistic broadly neutralizing immune response to hypervariable region 1 variants of hepatitis C virus
Mosa A, Campo D, Khudyakov Y, AbouHaidar M, Gehring A, Zahoor A, Ball J, Urbanowicz R, Feld J
2023, Proceedings of the National Academy of Sciences, 10.1073/pnas.2220294120
2021
Combating Human Viral Diseases: Will Plant-Based Vaccines Be the Answer?
Venkataraman S, Hefferon K, Makhzoum A, Abouhaidar M
2021, Vaccines, 10.3390/vaccines9070761
Novel approaches to circumvent the devastating effects of pests on sugarcane
Qamar Z, Nasir IA, Abouhaidar MG, Hefferon KL, Rao AQ, Latif A, Ali Q, Anwar S, Rashid B, Shahid AA
2021, Scientific Reports, 10.1038/s41598-021-91985-8
A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation
Naser Al Deen N, Atallah Lanman N, Chittiboyina S, Lelièvre S, Nasr R, Nassar F, Zu Dohna H, AbouHaidar M, Talhouk R
2021, Scientific Reports, 10.1038/s41598-021-82057-y
2020
Molecular interactions of plant viral satellites
Badar U, Venkataraman S, AbouHaidar M, Hefferon K
2020, Virus Genes, 10.1007/s11262-020-01806-9
A bivalent HCV peptide vaccine elicits pan-genotypic neutralizing antibodies in mice
Mosa AI, Urbanowicz RA, AbouHaidar MG, Tavis JE, Ball JK, Feld JJ
2020, Vaccine, 10.1016/j.vaccine.2020.08.066
Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV
Mosa AI, AbouHaidar MG, Urbanowicz RA, Tavis JE, Ball JK, Feld JJ
2020, Virology Journal, 10.1186/s12985-020-01408-9
2019
How Computational Epitope Mapping Identifies the Interactions between Nanoparticles Derived from Papaya Mosaic Virus Capsid Proteins and Immune System
Zamani-Babgohari M, Hefferon KL, Huang T, AbouHaidar MG
2019, Current Genomics, 10.2174/1389202920666190527080230
Connexin43 as a Tumor Suppressor: Proposed Connexin43 mRNA-circularRNAs-microRNAs Axis Towards Prevention and Early Detection in Breast Cancer
Naser Al Deen N, AbouHaidar M, Talhouk R
2019, Frontiers in Medicine, 10.3389/fmed.2019.00192
2017
Virus-Based RNA Silencing Agents and Virus-Derived Expression Vectors as Gene Therapy Vehicles
Venkataraman S, Ahmad T, AbouHaidar MG, Hefferon KL
2017, Recent Patents on Biotechnology, 10.2174/1872208311666170301103722
2016
Recent Patents in Oncolytic Virotherapy
Ahmad T, Venkataraman S, AbouHaidar M, L. Hefferon K
2016, Recent Patents on Biotechnology, 10.2174/187220830902160308183917
2014
Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt
AbouHaidar MG, Venkataraman S, Golshani A, Liu B, Ahmad T
2014, Proceedings of the National Academy of Sciences of the United States of America, 25253891
Viral and chloroplastic signals essential for initiation and efficiency of translation in Agrobacterium tumefaciens
Ahmad T, Venkataraman S, Hefferon K, AbouHaidar MG
2014, Biochemical and biophysical research communications, 452, 14-20, 25117444
2011
Recent patents involving virus nucleotide sequences; host defense, RNA silencing and expression vector strategies
Ahmad T, AbouHaidar M, Hefferon KL
2011, Recent patents on DNA & gene sequences, 5, 202-13, 21867477
Structural and sequence integrity are essential for the replication of the viroid-like satellite RNA of lucerne transient streak virus
Gellatly D, Mirhadi K, Venkataraman S, AbouHaidar MG
2011, The Journal of general virology, 92, 1475-81, 21346030
2007
Investigating the in vivo activity of the DeaD protein using protein-protein interactions and the translational activity of structured chloramphenicol acetyltransferase mRNAs
Butland G, Krogan NJ, Xu J, Yang WH, Aoki H, Li JS, Krogan N, Menendez J, Cagney G, Kiani GC, Jessulat MG, Datta N, Ivanov I, Abouhaidar MG, Emili A, Greenblatt J, Ganoza MC, Golshani A
2007, Journal of cellular biochemistry, 100, 642-52, 16983699
2004
Escherichia coli mRNAs with strong Shine/Dalgarno sequences also contain 5′ end sequences complementary to domain # 17 on the 16S ribosomal RNA
Golshani A, Krogan NJ, Xu J, Pacal M, Yang XC, Ivanov I, Providenti MA, Ganoza MC, Ivanov IG, AbouHaidar MG
2004, Biochemical and biophysical research communications, 316, 978-83, 15044080
2003
Induction of innate immunity by IL-2-expressing Salmonella confers protection against lethal infection
al-Ramadi BK, Mustafa N, AbouHaidar M, Fernandez-Cabezudo MJ
2003, Molecular immunology, 39, 763-70, 12617991