Rene E. Harrison




CSB Appointment


Research Areas

Cell Biology


Ph.D. University of Toronto 2000 M.Sc. University of Manitoba 1996

Primary Undergraduate Department

Biological Sciences, UTSC

Graduate Programs

Cell & Systems Biology
Laboratory Medicine & Pathobiology

Academic or Administrative Appointments

Associate Chair for Research

Research Description

My lab uses advanced fluorescent imaging to study the cell biology of immune cells and bone cells under normal and pathological states.

Contact Information

Office Phone: 416-287-7377
Office: SW415A
Lab: SW422
Lab Phone: 416-287-7440

Mailing Address

Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4



Modulation of osteoclastogenesis with macrophage m1- and m2-inducing stimuli

Jeganathan S, Fiorino C, Naik U, Sun HS, Harrison RE
2014, PloS one, 9, e104498, 25101660

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EB1 levels are elevated in ascorbic Acid (AA)-stimulated osteoblasts and mediate cell-cell adhesion-induced osteoblast differentiation

Pustylnik S, Fiorino C, Nabavi N, Zappitelli T, da Silva R, Aubin JE, Harrison RE
2013, The Journal of biological chemistry, 288, 22096-110, 23740245

Monocytes from patients with osteoarthritis display increased osteoclastogenesis and bone resorption: the In Vitro Osteoclast Differentiation in Arthritis study

Durand M, Komarova SV, Bhargava A, Trebec-Reynolds DP, Li K, Fiorino C, Maria O, Nabavi N, Manolson MF, Harrison RE, Dixon SJ, Sims SM, Mizianty MJ, Kurgan L, Haroun S, Boire G, de Fatima Lucena-Fernandes M, de Brum-Fernandes AJ
2013, Arthritis and rheumatism, 65, 148-58, 23044761

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Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts

Nabavi N, Pustylnik S, Harrison RE
2012, PloS one, 7, e46265, 23050002

Chlamydia trachomatis vacuole maturation in infected macrophages

Sun HS, Eng EW, Jeganathan S, Sin AT, Patel PC, Gracey E, Inman RD, Terebiznik MR, Harrison RE
2012, Journal of leukocyte biology, 92, 815-27, 22807527

Classically activated macrophages use stable microtubules for matrix metalloproteinase-9 (MMP-9) secretion

Hanania R, Sun HS, Xu K, Pustylnik S, Jeganathan S, Harrison RE
2012, The Journal of biological chemistry, 287, 8468-83, 22270361

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Chlamydia trachomatis inclusions induce asymmetric cleavage furrow formation and ingression failure in host cells

Sun HS, Wilde A, Harrison RE
2011, Molecular and cellular biology, 31, 5011-22, 21969606

Effects of microgravity on osteoclast bone resorption and osteoblast cytoskeletal organization and adhesion

Nabavi N, Khandani A, Camirand A, Harrison RE
2011, Bone, 49, 965-74, 21839189

Measuring immune receptor mobility by fluorescence recovery after photobleaching

Silver K, Harrison RE
2011, Methods in molecular biology (Clifton, N.J.), 748, 155-67, 21701973

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Kinesin 5B is necessary for delivery of membrane and receptors during FcγR-mediated phagocytosis

Silver KE, Harrison RE
2011, Journal of immunology (Baltimore, Md. : 1950), 186, 816-25, 21149599

Dynamic macrophage “probing” is required for the efficient capture of phagocytic targets

Flannagan RS, Harrison RE, Yip CM, Jaqaman K, Grinstein S
2010, The Journal of cell biology, 191, 1205-18, 21135140

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Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis

Botelho RJ, Harrison RE, Stone JC, Hancock JF, Philips MR, Jongstra-Bilen J, Mason D, Plumb J, Gold MR, Grinstein S
2009, The Journal of biological chemistry, 284, 28522-32, 19700408

Proteomic analysis of microtubule-associated proteins during macrophage activation

Patel PC, Fisher KH, Yang EC, Deane CM, Harrison RE
2009, Molecular & cellular proteomics : MCP, 8, 2500-14, 19651621

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Membrane ruffles capture C3bi-opsonized particles in activated macrophages

Patel PC, Harrison RE
2008, Molecular biology of the cell, 19, 4628-39, 18768756

Lysosome dispersion in osteoblasts accommodates enhanced collagen production during differentiation

Nabavi N, Urukova Y, Cardelli M, Aubin JE, Harrison RE
2008, The Journal of biological chemistry, 283, 19678-90, 18463099

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Cytoplasmic linker protein-170 enhances spreading and phagocytosis in activated macrophages by stabilizing microtubules

Binker MG, Zhao DY, Pang SJ, Harrison RE
2007, Journal of immunology (Baltimore, Md. : 1950), 179, 3780-91, 17785815

Microtubules regulate PI-3K activity and recruitment to the phagocytic cup during Fcgamma receptor-mediated phagocytosis in nonelicited macrophages

Khandani A, Eng E, Jongstra-Bilen J, Schreiber AD, Douda D, Samavarchi-Tehrani P, Harrison RE
2007, Journal of leukocyte biology, 82, 417-28, 17502337

MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages

Eng EW, Bettio A, Ibrahim J, Harrison RE
2007, Molecular biology of the cell, 18, 2389-99, 17442887

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Quantitative and dynamic assessment of the contribution of the ER to phagosome formation

Touret N, Paroutis P, Terebiznik M, Harrison RE, Trombetta S, Pypaert M, Chow A, Jiang A, Shaw J, Yip C, Moore HP, van der Wel N, Houben D, Peters PJ, de Chastellier C, Mellman I, Grinstein S
2005, Cell, 123, 157-70, 16213220

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Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria

Vieira OV, Harrison RE, Scott CC, Stenmark H, Alexander D, Liu J, Gruenberg J, Schreiber AD, Grinstein S
2004, Molecular and cellular biology, 24, 4593-604, 15121875

Salmonella impairs RILP recruitment to Rab7 during maturation of invasion vacuoles

Harrison RE, Brumell JH, Khandani A, Bucci C, Scott CC, Jiang X, Finlay BB, Grinstein S
2004, Molecular biology of the cell, 15, 3146-54, 15121880

Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton

Harrison RE, Sikorski BA, Jongstra J
2004, Journal of cell science, 117, 2151-7, 15090600

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Phagocytosis by neutrophils

Lee WL, Harrison RE, Grinstein S
2003, Microbes and infection / Institut Pasteur, 5, 1299-306, 14613773

Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP

Harrison RE, Bucci C, Vieira OV, Schroer TA, Grinstein S
2003, Molecular and cellular biology, 23, 6494-506, 12944476

Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase

Vieira OV, Bucci C, Harrison RE, Trimble WS, Lanzetti L, Gruenberg J, Schreiber AD, Stahl PD, Grinstein S
2003, Molecular and cellular biology, 23, 2501-14, 12640132

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Microbial killing: oxidants, proteases and ions

Harrison RE, Touret N, Grinstein S
2002, Current biology : CB, 12, R357-9, 12015137

Phagocytosis and the microtubule cytoskeleton

Harrison RE, Grinstein S
2002, Biochemistry and cell biology = Biochimie et biologie cellulaire, 80, 509-15, 12440692

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