Tod Thiele

Assistant Professor



CSB Appointment


Research Areas

Neurobiology, Systems Biology


University of Oregon Ph.D. in Biology 2007
Hamilton College BA in Biology 1999

Primary Undergraduate Department

Biological Sciences, UTSC

Graduate Programs

Cell & Systems Biology

Research Description

Our research uses zebrafish to investigate how neural circuits control behaviour. To gain insights into neural circuit function we use a combination of behavioural analyses, calcium imaging, optogenetics and genome engineering.

Contact Information

Office Phone: 416-287-7035
Office: SW421E

Mailing Address

Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4



The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish.

Carbo-Tano M, Lapoix M, Jia X, Thouvenin O, Pascucci M, Auclair F, Quan FB, Albadri S, Aguda V, Farouj Y, Hillman EMC, Portugues R, Del Bene F, Thiele TR, Dubuc R, Wyart C
2023, Nature neuroscience, 37667039

Spatiotemporal visual statistics of aquatic environments in the natural habitats of zebrafish

Cai LT, Krishna VS, Hladnik TC, Guilbeault NC, Vijayakumar C, Arunachalam M, Juntti SA, Arrenberg AB, Thiele TR, Cooper EA
2023, Scientific Reports, 10.1038/s41598-023-36099-z

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Optic flow in the natural habitats of zebrafish supports spatial biases in visual self-motion estimation

Alexander E, Cai LT, Fuchs S, Hladnik TC, Zhang Y, Subramanian V, Guilbeault NC, Vijayakumar C, Arunachalam M, Juntti SA, Thiele TR, Arrenberg AB, Cooper EA
2022, Current Biology, 10.1016/j.cub.2022.10.009

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BonZeb: open-source, modular software tools for high-resolution zebrafish tracking and analysis

Guilbeault NC, Guerguiev J, Martin M, Tate I, Thiele TR
2021, Scientific Reports, 10.1038/s41598-021-85896-x

Manipulation of the Tyrosinase gene permits improved CRISPR/Cas editing and neural imaging in cichlid fish

Li C, Steighner JR, Sweatt G, Thiele TR, Juntti SA
2021, Scientific Reports, 10.1038/s41598-021-94577-8

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Parallel Channels for Motion Feature Extraction in the Pretectum and Tectum of Larval Zebrafish

Wang K, Hinz J, Zhang Y, Thiele TR, Arrenberg AB
2020, Cell Reports, 10.1016/j.celrep.2019.12.031

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A dedicated visual pathway for prey detection in larval zebrafish

Semmelhack JL, Donovan JC, Thiele TR, Kuehn E, Laurell E, Baier H
2014, eLife, 3, 25490154

Descending control of swim posture by a midbrain nucleus in zebrafish

Thiele TR, Donovan JC, Baier H
2014, Neuron, 83, 679-91, 25066082

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An image-free opto-mechanical system for creating virtual environments and imaging neuronal activity in freely moving Caenorhabditis elegans

Faumont S, Rondeau G, Thiele TR, Lawton KJ, McCormick KE, Sottile M, Griesbeck O, Heckscher ES, Roberts WM, Doe CQ, Lockery SR
2011, PloS one, 6, e24666, 21969859

Optogenetic analysis of synaptic transmission in the central nervous system of the nematode Caenorhabditis elegans

Lindsay TH, Thiele TR, Lockery SR
2011, Nature communications, 2, 306, 21556060

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The neural network for chemotaxis to tastants in Caenorhabditis elegans is specialized for temporal differentiation

Thiele TR, Faumont S, Lockery SR
2009, The Journal of neuroscience : the official journal of the Society for Neuroscience, 29, 11904-11, 19776276

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Functional asymmetry in Caenorhabditis elegans taste neurons and its computational role in chemotaxis

Suzuki H, Thiele TR, Faumont S, Ezcurra M, Lockery SR, Schafer WR
2008, Nature, 454, 114-7, 18596810

Artificial dirt: microfluidic substrates for nematode neurobiology and behavior

Lockery SR, Lawton KJ, Doll JC, Faumont S, Coulthard SM, Thiele TR, Chronis N, McCormick KE, Goodman MB, Pruitt BL
2008, Journal of neurophysiology, 99, 3136-43, 18337372

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Step-response analysis of chemotaxis in Caenorhabditis elegans

Miller AC, Thiele TR, Faumont S, Moravec ML, Lockery SR
2005, The Journal of neuroscience : the official journal of the Society for Neuroscience, 25, 3369-78, 15800192

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Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans

Davies AG, Bettinger JC, Thiele TR, Judy ME, McIntire SL
2004, Neuron, 42, 731-43, 15182714

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A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans

Davies AG, Pierce-Shimomura JT, Kim H, VanHoven MK, Thiele TR, Bonci A, Bargmann CI, McIntire SL
2003, Cell, 115, 655-66, 14675531

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