Vincent Tropepe

Professor and Vice Dean, Research


St. George (downtown)

CSB Appointment


Research Areas

Animal Biology, Cell Biology, Developmental Biology, Genetics / Genomics, Molecular Biology, Neurobiology, Systems Biology


Ph.D. University of Toronto 2000
B.Sc. McMaster University 1994

Primary Undergraduate Department

Cell & Systems Biology

Graduate Programs

Cell & Systems Biology

Academic or Administrative Appointments

Vice-Dean, Research (Faculty of Arts & Science)

Research Description

The production of nerve cells (neurogenesis) is a life-long process with regional specialization that is critical for the formation of distinct functional domains in the vertebrate nervous system. Moreover, neurogenesis in the mature nervous system may contribute to the structural changes that underlie neural plasticity, which is crucial for sensory processing and behaviour. My lab investigates how neurogenesis contributes to the generation and maintenance of regional nerve cell diversity throughout life. We utilize various molecular genetic techniques in order to identify and characterize the molecular mechanisms that govern vertebrate neurogenesis.

Contact Information

Office Phone: 416-946-0338
Office: RW618A
Lab: RW607/RW618/RW619
Lab Phone: 416-946-0593 / 416-946-7218

Mailing Address

Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5

Visit lab’s website

Recent News

Long-term Research at CSB supported by NSERC Discovery Grants 2022

Congratulations to five researchers at CSB who have earned Discovery Grants starting in 2022 from the National Science and Engineering Research…

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Congratulations to F Michael Barrett Award 2022 winners from CSB!

Students taking our CSB497/CSB498/CSB499 courses earned valuable experience in CSB research labs, gaining skills and knowledge in specific fields…

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Tropepe lab reveals reduced photoreceptor integrity underlying Usher Syndrome

Dr Amanda Miles of the Tropepe lab shows that "Usher syndrome type 1-associated gene, pcdh15b, is required for photoreceptor structural integrity in…

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Usher syndrome type 1-associated gene, pcdh15b, is required for photoreceptor structural integrity in zebrafish

Miles A, Blair C, Emili A, Tropepe V
2021, Disease Models & Mechanisms, 10.1242/dmm.048965

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Neural stem cell heterogeneity.

Joly JS, Tropepe V
2018, Progress in neurobiology, 170, 1, 30316517

The role of neuro-epithelial-like and radial-glial stem and progenitor cells in development, plasticity, and repair.

Lindsey BW, Hall ZJ, Heuzé A, Joly JS, Tropepe V, Kaslin J
2018, Progress in neurobiology, 170, 99-114, 29902500

Movement maintains forebrain neurogenesis via peripheral neural feedback in larval zebrafish.

Hall ZJ, Tropepe V
2018, eLife, 7, 29528285

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Cone-like rhodopsin expressed in the all-cone retina of the colubrid pine snake as a potential adaptation to diurnality.

Bhattacharyya N, Darren B, Schott RK, Tropepe V, Chang BSW
2017, The Journal of experimental biology, 220, 2418-2425, 28468872

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A second visual rhodopsin gene, rh1-2, is expressed in zebrafish photoreceptors and found in other ray-finned fishes.

Morrow JM, Lazic S, Dixon Fox M, Kuo C, Schott RK, de A Gutierrez E, Santini F, Tropepe V, Chang BS
2017, The Journal of experimental biology, 220, 294-303, 27811293

G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis.

Olsen JB, Wong L, Deimling S, Miles A, Guo H, Li Y, Zhang Z, Greenblatt JF, Emili A, Tropepe V
2016, Stem cell reports, 7, 454-470, 27546533

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Evolutionary transformation of rod photoreceptors in the all-cone retina of a diurnal garter snake.

Schott RK, Müller J, Yang CG, Bhattacharyya N, Chan N, Xu M, Morrow JM, Ghenu AH, Loew ER, Tropepe V, Chang BS
2016, Proceedings of the National Academy of Sciences of the United States of America, 113, 356-61, 26715746

Nonsense mutation in the WDR73 gene is associated with Galloway-Mowat syndrome.

Ben-Omran T, Fahiminiya S, Sorfazlian N, Almuriekhi M, Nawaz Z, Nadaf J, Khadija KA, Zaineddin S, Kamel H, Majewski J, Tropepe V
2015, Journal of medical genetics, 52, 381-90, 25873735

Mutual antagonism of the paired-type homeobox genes, vsx2 and dmbx1, regulates retinal progenitor cell cycle exit upstream of ccnd1 expression.

Wong L, Power N, Miles A, Tropepe V
2015, Developmental biology, 402, 216-28, 25872183

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Changes in the social environment induce neurogenic plasticity predominantly in niches residing in sensory structures of the zebrafish brain independently of cortisol levels

Lindsey BW, Tropepe V
2014, Developmental neurobiology, 24753454

Casting a wider fish net on animal models in neuropsychiatric research

Hall ZJ, De Serrano AR, Rodd FH, Tropepe V
2014, Progress in neuro-psychopharmacology & biological psychiatry, 24726811

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Cockayne syndrome b maintains neural precursor function

Sacco R, Tamblyn L, Rajakulendran N, Bralha FN, Tropepe V, Laposa RR
2013, DNA repair, 12, 110-20, 23245699

Toll-like signaling and the cytokine IL-6 regulate histone deacetylase dependent neuronal survival

Forgione N, Tropepe V
2012, PloS one, 7, e41033, 22848425

The cellular composition of neurogenic periventricular zones in the adult zebrafish forebrain

Lindsey BW, Darabie A, Tropepe V
2012, The Journal of comparative neurology, 520, 2275-316, 22318736

Zfhx1b induces a definitive neural stem cell fate in mouse embryonic stem cells

Dang LT, Wong L, Tropepe V
2012, Stem cells and development, 21, 2838-51, 22594450

The ontogeny of somatic stem cells

Tropepe V, Turksen K
2012, Stem cell reviews, 8, 548-50, 22529018

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Histone deacetylase inhibition promotes Caspase-independent cell death of ventral midbrain neurons

Forgione N, Tropepe V
2011, Molecular and cellular neurosciences, 48, 117-28, 21763771

The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress

Sanghera KP, Mathalone N, Baigi R, Panov E, Wang D, Zhao X, Hsu H, Wang H, Tropepe V, Ward M, Boyd SR
2011, Molecular and cellular neurosciences, 47, 145-53, 21463685

Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae

Souza BR, Romano-Silva MA, Tropepe V
2011, The Journal of neuroscience : the official journal of the Society for Neuroscience, 31, 5512-25, 21471388

The role of dopaminergic signalling during larval zebrafish brain development: a tool for investigating the developmental basis of neuropsychiatric disorders

Souza BR, Tropepe V
2011, Reviews in the neurosciences, 22, 107-19, 21615265

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Waste management and adult neurogenesis

Mattocks M, Tropepe V
2010, Cell stem cell, 7, 421-2, 20887944

Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development

Wong L, Weadick CJ, Kuo C, Chang BS, Tropepe V
2010, BMC developmental biology, 10, 100, 20860823

FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm

Dang LT, Tropepe V
2010, Neural development, 5, 13, 20459606

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Neurogenic potential of isolated precursor cells from early post-gastrula somitic tissue

Tropepe V, Alton K, Sachewsky N, Cheng V, Kuo C, Morshead CM
2009, Stem cells and development, 18, 1533-42, 19326969

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Kinship and Descent: Redefining the Stem Cell Compartment in the Adult Hippocampus

Tropepe V
2007, Cell stem cell, 1, 481-483, 18371384

Kinship and descent: redefining the stem cell compartment in the adult hippocampus

Tropepe V
2007, Cell stem cell, 1, 481-3, 18938741

A comparative framework for understanding the biological principles of adult neurogenesis

Lindsey BW, Tropepe V
2006, Progress in neurobiology, 80, 281-307, 17218052

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Neural induction and neural stem cell development

Dang L, Tropepe V
2006, Regenerative medicine, 1, 635-52, 17465732

Genomic sequence and spatiotemporal expression comparison of zebrafish mbx1 and its paralog, mbx2

Chang L, Khoo B, Wong L, Tropepe V
2006, Development genes and evolution, 216, 647-54, 16733737

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Identification of a BMP inhibitor-responsive promoter module required for expression of the early neural gene zic1

Tropepe V, Li S, Dickinson A, Gamse JT, Sive HL
2006, Developmental biology, 289, 517-29, 16307736

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Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D
2002, Genes & development, 16, 846-58, 11937492

Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain

Hitoshi S, Tropepe V, Ekker M, van der Kooy D
2002, Development (Cambridge, England), 129, 233-44, 11782416

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